Synthesis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 11, 2024
Abstract
Sulfur(VI)
fluoride
exchange
(SuFEx)
chemistry
that
relies
on
the
unique
reactivity–stability
balance
of
high
valent
organosulfur
has
emerged
as
a
promising
topic
for
next-generation
click
reaction.
Sulfonyl
fluorides
are
most
widely
used
connective
hubs
SuFEx
reaction
with
widespread
applications
in
fields
chemical
biology,
drug
discovery,
and
materials
science.
Compared
current
methods,
direct
fluorosulfonylation
fluorosulfonyl
radicals
concise
efficient
approach
production
sulfonyl
fluorides.
The
highly
active
SO2F
radical
was
an
unstable
inaccessible
precursor
until
it
observed
decomposition
azide,
which
inspired
efforts
towards
precursors
processes.
This
review
presents
discusses
breakthroughs
generation
from
various
precursors,
well
their
application
synthesis
diverse
functionalized
1
Introduction
2
FSO2Cl
Radical
Precursor
3
Benzimidazolium
Fluorosulfonates
Precursors
4
Alk-1-ynylsulfonyl
Fluorides
5
(Diarylmethylene)sulfamoyl
6
Vinyl
Fluorosulfates
7
Conclusion
Outlook
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(42), P. 9132 - 9137
Published: Oct. 16, 2024
Both
fluorosulfonyl
and
cyano
groups
are
important
structural
motifs
in
bioactive
molecules.
Herein,
we
report
a
new
difunctionalization
reaction
of
alkenes
based
on
radicals,
which
allows
for
the
introduction
into
unactivated
one
step.
This
transformation
is
enabled
by
merging
photoredox
copper
catalysis,
featuring
visible
light
mild
conditions,
good
functional
group
tolerance.
Further
products
via
SuFEx
reactions
also
demonstrated.
Synthesis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 11, 2024
Abstract
Sulfur(VI)
fluoride
exchange
(SuFEx)
chemistry
that
relies
on
the
unique
reactivity–stability
balance
of
high
valent
organosulfur
has
emerged
as
a
promising
topic
for
next-generation
click
reaction.
Sulfonyl
fluorides
are
most
widely
used
connective
hubs
SuFEx
reaction
with
widespread
applications
in
fields
chemical
biology,
drug
discovery,
and
materials
science.
Compared
current
methods,
direct
fluorosulfonylation
fluorosulfonyl
radicals
concise
efficient
approach
production
sulfonyl
fluorides.
The
highly
active
SO2F
radical
was
an
unstable
inaccessible
precursor
until
it
observed
decomposition
azide,
which
inspired
efforts
towards
precursors
processes.
This
review
presents
discusses
breakthroughs
generation
from
various
precursors,
well
their
application
synthesis
diverse
functionalized
1
Introduction
2
FSO2Cl
Radical
Precursor
3
Benzimidazolium
Fluorosulfonates
Precursors
4
Alk-1-ynylsulfonyl
Fluorides
5
(Diarylmethylene)sulfamoyl
6
Vinyl
Fluorosulfates
7
Conclusion
Outlook
