Nanozyme for tumor therapy: Surface modification matters

Exploration, Год журнала: 2021, Номер 1(1), С. 75 - 89

Опубликована: Авг. 1, 2021

As the next generation of artificial enzymes, nanozymes have shown unique properties compared to its natural counterparts, such as stability in harsh environment, low cost, and ease production modification, paving way for biomedical applications. Among them, tumor catalytic therapy mediated by reactive oxygen species (ROS) has made great progress mainly from peroxidase-like activity nanozymes. Fe

Язык: Английский

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Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Янв. 11, 2023

Nanozymes with superoxide dismutase (SOD)-like activity have attracted increasing interest due to their ability scavenge anion, the origin of most reactive oxygen species in vivo. However, SOD nanozymes reported thus far yet approach natural enzymes. Here, we report a carbon dot (C-dot) nanozyme catalytic over 10,000 U/mg, comparable that Through selected chemical modifications and theoretical calculations, show SOD-like C-dots relies on hydroxyl carboxyl groups for binding anions carbonyl conjugated π-system electron transfer. Moreover, C-dot exhibit intrinsic targeting oxidation-damaged cells effectively protect neuron ischemic stroke male mice model. Together, our study sheds light structure-activity relationship nanozymes, demonstrates potential treating oxidation stress related diseases.

Язык: Английский

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Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Chemical Society Reviews, Год журнала: 2022, Номер 51(12), С. 4996 - 5041

Опубликована: Янв. 1, 2022

This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.

Язык: Английский

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Depletable peroxidase-like activity of Fe3O4 nanozymes accompanied with separate migration of electrons and iron ions

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Сен. 12, 2022

As pioneering Fe

Язык: Английский

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A Bioinspired Five‐Coordinated Single‐Atom Iron Nanozyme for Tumor Catalytic Therapy

Advanced Materials, Год журнала: 2022, Номер 34(15)

Опубликована: Фев. 1, 2022

Single-atom nanozymes (SAzymes) represent a new research frontier in the biomedical fields. The rational design and controllable synthesis of SAzymes with well-defined electronic geometric structures are essential for maximizing their enzyme-like catalytic activity therapeutic efficacy but remain challenging. Here, melamine-mediated pyrolysis activation strategy is reported fabrication iron-based SAzyme containing five-coordinated structure (FeN5 ), identified by transmission electron microscopy imaging X-ray absorption fine analyses. FeN5 exhibits superior peroxidase-like owing to optimized coordination structure, corresponding efficiency Fe-species 7.64 3.45 × 105 times higher than those traditional FeN4 Fe3 O4 nanozyme, respectively, demonstrated steady-state kinetic assay. In addition, mechanism jointly disclosed experimental results density functional theory studies. as-synthesized demonstrates significantly enhanced antitumor effect vitro vivo due excellent under tumor microenvironment.

Язык: Английский

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Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

Nano-Micro Letters, Год журнала: 2022, Номер 14(1)

Опубликована: Апрель 6, 2022

Abstract Natural enzymes usually suffer from high production cost, ease of denaturation and inactivation, low yield, making them difficult to be broadly applicable. As an emerging type artificial enzyme, nanozymes that combine the characteristics nanomaterials are promising alternatives. On one hand, have enzyme-like catalytic activities regulate biochemical reactions. other also inherit properties nanomaterials, which can ameliorate shortcomings natural serve as versatile platforms for diverse applications. In this review, various mimic activity different introduced. The achievements in cancer diagnosis treatment technologies summarized by highlighting advantages these Finally, future research directions rapidly developing field outlooked."Image missing"

Язык: Английский

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Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Авг. 12, 2022

Regenerable nanozymes with high catalytic stability and sustainability are promising substitutes for naturally-occurring enzymes but limited by insufficient non-selective activities. Herein, we developed single-atom of RhN

Язык: Английский

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Edge‐Site Engineering of Defective Fe–N₄ Nanozymes with Boosted Catalase‐Like Performance for Retinal Vasculopathies

Advanced Materials, Год журнала: 2022, Номер 34(39)

Опубликована: Авг. 12, 2022

Extensive efforts are devoted to refining metal sites for optimizing the catalytic performance of single-atom nanozymes (SANzymes), while contribution defect environment neighboring lacks attention. Herein, an iron-based SANzyme (Fe-SANzyme) is rationally designed by edge-site engineering, which intensively exposes edge-hosted defective Fe-N4 atomic anchored in hierarchical mesoporous structures. The Fe-SANzyme exhibits excellent catalase-like activity capable efficiently catalyzing decomposition H2 O2 into and O, with a kinetic KM value superior that natural catalase reported nanozymes. mechanistic studies depict defects introduce notable charge transfer from Fe atom carbon matrix, making central more activated strengthen interaction weaken OO bond. By performing catalysis, significantly scavenges reactive oxygen species (ROS) alleviates oxidative stress, thus eliminating pathological angiogenesis animal models retinal vasculopathies without affecting repair normal vessels. This work provides new way refine SANzymes engineering geometric structure around sites, demonstrates potential therapeutic effects nanozyme on vasculopathies.

Язык: Английский

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Piezotronic Effect-Augmented Cu_2–xO–BaTiO₃ Sonosensitizers for Multifunctional Cancer Dynamic Therapy

ACS Nano, Год журнала: 2022, Номер 16(6), С. 9304 - 9316

Опубликована: Июнь 14, 2022

Ultrasound (US)-triggered sonodynamic therapy (SDT) based on semiconductor nanomaterials has attracted considerable attention for cancer therapy. However, most inorganic sonosensitizers suffer from low efficiency due to the rapid recombination of electron-hole pairs. Herein, Cu2-xO-BaTiO3 piezoelectric heterostructure was fabricated as a sonosensitizer and chemodynamic agent, simultaneously, improving reactive oxygen species (ROS) generation therapeutic outcome. Under US irradiation, heterojunction with piezotronic effect exhibits high-performance singlet (1O2) hydroxyl radical (•OH) enhance SDT. Moreover, it possesses Fenton-like reaction activity convert endogenous H2O2 into •OH (CDT). The integration SDT CDT substantially boosts ROS cellular mitochondria damage, in vitro vivo results demonstrate high cytotoxicity tumor inhibition murine refractory breast cancer. This work realizes improvement using heterostructures effects.

Язык: Английский

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Unveiling the active sites on ferrihydrite with apparent catalase-like activity for potentiating radiotherapy

Nano Today, Год журнала: 2021, Номер 41, С. 101317 - 101317

Опубликована: Окт. 29, 2021

The use of catalase-like nanozymes in relieving tumor hypoxia has been a promising strategy for adjuvant radiotherapy, yet their catalytic mechanism and toxic potential remain elusive. While most studies on mechanisms focus the substrates products process, little is reported to analyze dominating surface structure activity nanozymes. Here, we ferrihydrite revealed its structure-activity relationship. Among ten main forms iron oxide nanomaterials, ferrihydrite, especially 2-line exhibited highest activity. Importantly, fitting density functional analysis that abundant iron-associated hydroxyl groups dominantly affect ferrihydrites. In addition, no peroxidase-like superoxide dismutase-like activities, constantly catalyzed decomposition H2O2 release O2 pH range 4.0–8.7. With help steady single physiological environment, safely effectively microenvironment in-situ produce significantly enhanced therapeutic effect radiotherapy. Moreover, excellent biosafety biodegradability. These findings demonstrate great as biocompatible nanozyme cancer therapy.

Язык: Английский

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