Biosystem‐Inspired Engineering of Nanozymes for Biomedical Applications

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Янв. 9, 2023

Abstract Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to become surrogates of natural enzymes in many fields by virtue their advantages high catalytic stability, ease functionalization, and low cost. However, due the lack predictable descriptors, most nanozymes reported past been obtained mainly through trial‐and‐error strategies, efficacy, substrate specificity, as well practical application effect under physiological conditions, are far inferior that enzymes. To optimize efficacies functions biomedical settings, recent studies introduced biosystem‐inspired strategies into nanozyme design. In this review, advances engineering leveraging refined structure enzymes, simulating behavior changes process, mimicking specific biological processes or living organisms, introduced. Furthermore, currently involved applications summarized. More importantly, current opportunities challenges design discussed. It is hoped based on bioinspired will be beneficial for constructing new generation broadening applications.

Язык: Английский

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Dual Nanozyme-Driven PtSn Bimetallic Nanoclusters for Metal-Enhanced Tumor Photothermal and Catalytic Therapy

ACS Nano, Год журнала: 2023, Номер 17(7), С. 6833 - 6848

Опубликована: Март 28, 2023

Specific generation of reactive oxygen species (ROS) within tumors in situ catalyzed by nanozymes is a promising strategy for cancer therapeutics. However, it remains significant challenge to fabricate highly efficient acting the tumor microenvironment. Herein, we develop bimetallic nanozyme (Pt50Sn50) with photothermal enhancement dual enzymatic activities catalytic therapy. The structures and PtSn nanoclusters (BNCs) different Sn content are explored evaluated systematically. Experimental comparisons show that Pt50Sn50 BNCs exhibit highest among all those investigated, including activity property, due SnO2–x vacancy (Ovac) sites on surface BNCs. Specifically, photothermal-enhanced peroxidase-like catalase-like activities, as well significantly enhanced anticancer efficacy both multicellular spheroids vivo experiments. Due high X-ray attenuation coefficient excellent light absorption also dual-mode imaging capacity computed tomography photoacoustic imaging, which could achieve real-time monitoring therapeutic process. Therefore, this work will advance development noble-metal optimal composition

Язык: Английский

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Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Nano-Micro Letters, Год журнала: 2023, Номер 15(1)

Опубликована: Фев. 8, 2023

Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity few adverse effects. Currently, the development of functional vectors safety effectiveness is intense focus for improving delivery nucleic acid drugs gene therapy. For this purpose, stimuli-responsive nanocarriers displayed strong potential overall efficiencies reducing effects via effective protection, prolonged blood circulation, specific tumor accumulation, controlled release profile drugs. Besides, synergistic could be achieved when combined other therapeutic regimens. This review summarizes recent advances various delivery. Particularly, responding to endogenous stimuli including pH, reactive oxygen species, glutathione, enzyme, etc., exogenous light, thermo, ultrasound, magnetic field, are introduced. Finally, future challenges prospects toward clinical translation well discussed. The major objective present biomedical cancer provide guidance developing novel nanoplatforms that clinically applicable.

Язык: Английский

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Microenvironment‐Activated Nanozyme‐Armed Bacteriophages Efficiently Combat Bacterial Infection

Advanced Materials, Год журнала: 2023, Номер 35(30)

Опубликована: Апрель 21, 2023

Bacterial infection is one of the greatest challenges to public health, requiring new therapeutic methods. Herein, an innovative nanozyme-armed phage (phage@palladium (Pd)) system fabricated for combating bacterial infection. The proposed phage@Pd preserves function phages achieve precise recognition and adhesion host Escherichia coli. In aid phages, ultrasmall Pd nanozymes equipped with conspicuous pH-dependent peroxidase-like activity can generate toxic hydroxyl radical around bacteria in acidic hydrogen-peroxide-overexpressed microenvironment while remaining inert physiological conditions, thus realizing noteworthy elimination at infected sites, meantime ensuring biological safety healthy tissues. addition, filamentous structure also enhance its bactericidal efficiency toward nonhost by randomly entangling on them, indicating possible broad-spectrum germicidal efficacy. Notably, not only eradicate planktonic bacteria, but kill inside biofilm vitro. For both vivo models acute pneumonia or subcutaneous abscess, shows significant eliminating promoting tissue recovery. These results demonstrate that nanohybrid a safe effective antimicrobial agent, providing insight into development advanced antibacterial materials.

Язык: Английский

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Functional catalytic nanoparticles (nanozymes) for sensing

Biosensors and Bioelectronics, Год журнала: 2022, Номер 218, С. 114768 - 114768

Опубликована: Окт. 3, 2022

Язык: Английский

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Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

Nano-Micro Letters, Год журнала: 2023, Номер 16(1)

Опубликована: Ноя. 21, 2023

Since the discovery of enzyme-like activity Fe

Язык: Английский

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Carbon dots as potential antioxidants for the scavenging of multi-reactive oxygen and nitrogen species

Chemical Engineering Journal, Год журнала: 2023, Номер 462, С. 142338 - 142338

Опубликована: Март 9, 2023

Язык: Английский

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Breaking the pH Limitation of Nanozymes: Mechanisms, Methods, and Applications

Advanced Materials, Год журнала: 2024, Номер 36(31)

Опубликована: Апрель 14, 2024

Although nanozymes have drawn great attention over the past decade, activities of peroxidase-like, oxidase-like, and catalase-like are often pH dependent with elusive mechanism, which largely restricts their application. Therefore, a systematical discussion on pH-related catalytic mechanisms together methods to overcome this limitation is in need. In review, various exhibiting pH-dependent collected root causes for dependence comprehensively analyzed. Subsequently, regulatory concepts including environment reconstruction direct activity improvement break restriction summarized. Moreover, applications pH-independent sensing, disease therapy, pollutant degradation overviewed. Finally, current challenges future opportunities development suggested. It anticipated that review will promote further design broaden application range higher efficiency.

Язык: Английский

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Enhanced Peroxidase-Mimic Catalytic Activity via Cerium Doping of Strontium-Based Metal–Organic Frameworks with Design of a Smartphone-Based Sensor for On-Site Salivary Total Antioxidant Capacity Detection in Lung Cancer Patients

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(17), С. 21239 - 21251

Опубликована: Апрель 18, 2023

The development of artificial nanozymes with superior catalytic performance and excellent stability has been a long-standing objective for chemists. total antioxidant capacity (TAC) is one the most important bioanalytical measures oxidative stress in body. present work aims to develop smartphone-assisted visual detection sensor using cerium-doped strontium-based metal-organic frameworks (Ce-SrMOFs) as peroxidase-like rapid, low-cost, on-site TAC. pristine SrMOF functioned peroxidase nanozyme, its enzymatic activity was enhanced after doping it Ce(IV) ions because multivalent nature synergistic impact heteroatoms. Ce-SrMOFs were sensitive single electron transfer hydrogen atom processes, which implies that can serve an ideal nanozyme candidate TAC analysis. investigated mechanism revealed •OH active oxygen species activity. exhibited strong affinity 3,3',5,5'-tetramethylbenzidine (TMB) H2O2, Km values 0.082 0.427 mM, are 5.29- 8.67-fold lower than those horseradish (HRP), respectively. used ascorbic acid, cysteine, glutathione, limits 44, 53, 512 nM, proposed method proved effective measuring saliva samples from lung cancer patients, thereby yielding results satisfactory precision accuracy.

Язык: Английский

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Single‐Atom Nanozymes for Catalytic Therapy: Recent Advances and Challenges

Advanced Functional Materials, Год журнала: 2024, Номер 34(16)

Опубликована: Янв. 4, 2024

Abstract As a powerful tool, nanozyme catalysts broaden the avenues to implement bio‐inspired solutions for addressing many important concerns, covering energy, healthcare, environment, and more. Recent endeavors, characterized by atomic precision, have enabled extensive exploration of single‐atom nanozymes (SAzymes) with high catalytic activity, superior substrate selectivity, integrated multifunctionalities, thus becoming an emerging field that bridges nanotechnology biology. This review provides brief outline progress summarizes latest research advances regarding SAzymes in biomedical therapeutics, mainly including tumor therapy, wound antibacterial tissue anti‐inflammatory focus on their prototypical synthesis therapeutic mechanisms. Finally, current challenges future perspectives engineering advanced are also discussed outlooked. It is anticipated this area shall provide useful guidance therapy.

Язык: Английский

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