Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 11, 2025
As
one
of
the
stem
cell
markers,
chromobox
protein
homolog
3
(CBX3)
participates
in
multiple
signaling
pathways
that
affect
progression
various
tumors.
However,
role
CBX3
melanoma
remains
unclear,
and
mechanisms
by
which
may
regulate
immunotherapy
outcome
remain
largely
unknown.
We
used
Cancer
Genome
Atlas,
Genotype-Tissue
Expression
portal,
Gene
Omnibus
database
to
estimate
expression
its
prognostic
effect
melanoma.
The
proliferation
migration
cells
were
examined
using
CCK8,
cloning,
wound
healing,
transwell
assays.
on
tumorigenesis
was
assessed
an
vivo
animal
model.
cycle
flow
cytometry,
levels
cycle-related
genes
proteins
with
altered
analyzed
qPCR
western
blotting.
function
immune
microenvironment
studied
single-cell
RNA
sequencing
public
databases.
found
highly
expressed
poor
prognosis.
promoted
vitro.
Functional
analysis
revealed
regulates
cycle,
as
it
accelerated
G1
S
transition,
decreased
p21
expression,
increased
CDK6
expression.
Finally,
immune-related
assays
showed
is
immunogenic
can
change
conclude
marker,
activates
p21/CDK6
pathway
alters
Abstract
Polyoxometalates
(POM)
are
a
class
of
inorganic
metal
oxides
with
distinctive
structural
characteristics,
compositional
versatility,
high
catalytic
efficacy,
and
convenient
storage
properties.
In
recent
years,
POM
have
shown
considerable
potential
for
mimicking
enzyme
activities.
Besides
their
biological
activities,
been
demonstrated
to
possess
the
ability
sense
diseases
perform
synergistic
therapies
based
on
redox
near‐infrared
absorption
Similar
metallic
nanoparticles
organic
materials,
these
clusters
also
exhibit
photothermal
imaging
therapeutic
Based
this,
current
review
focuses
exclusively
application
in
therapy
tumors.
Furthermore,
advantages
issues
associated
POM‐based
nanomaterials
tumor
discussed
analyzed.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 4, 2025
Chimeric
antigen
receptor
(CAR)
immune
cell
therapies
have
revolutionized
oncology,
particularly
in
hematological
malignancies,
yet
their
efficacy
against
solid
tumors
remains
limited
due
to
challenges
such
as
dense
stromal
barriers
and
immunosuppressive
microenvironments.
With
advancements
nanobiotechnology,
researchers
developed
various
strategies
methods
enhance
the
CAR
tumor
treatment.
In
this
Review,
we
first
outline
structure
mechanism
of
CAR-T
(T,
T
cell),
CAR-NK
(NK,
natural
killer),
CAR-M
(M,
macrophage)
deeply
analyze
potential
these
cells
treatment
they
face.
Next,
explore
how
biomaterials
can
optimize
treatments
by
improving
microenvironment,
controlling
release,
promoting
infiltration,
enhancing
efficacy.
Finally,
summarize
current
solutions,
emphasize
effective
combination
therapy,
look
forward
its
future
clinical
application
strategies.
This
Review
provides
important
theoretical
perspectives
practical
guidance
for
development
more
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 10, 2025
Over
the
past
decades,
significant
progress
has
been
made
in
understanding
of
non-small
cell
lung
cancer
(NSCLC)
biology
and
tumor
progression
mechanisms,
resulting
development
novel
strategies
for
early
detection
wide-ranging
care
approaches.
Since
their
introduction,
over
20
years
ago,
targeted
therapies
with
tyrosine
kinase
inhibitors
(TKIs)
have
revolutionized
treatment
landscape
NSCLC.
Nowadays,
remain
gold
standard
many
patients,
but
still
they
suffer
from
adverse
effects,
including
unexpected
toxicity
intrinsic
acquired
resistance
mutations,
which
lead
to
relapse.
The
adoption
immune
checkpoint
(ICIs)
2015,
offered
exceptional
survival
benefits
patients
without
targetable
alterations.
Despite
this
notable
progress,
challenges
remain,
as
not
all
respond
favorably
ICIs,
therapy
can
develop
time.
A
crucial
factor
influencing
clinical
response
immunotherapy
is
microenvironment
(TME).
TME
pivotal
orchestrating
interactions
between
neoplastic
cells
system,
growth
outcomes.
In
review,
we
discuss
how
intricate
relationship
success
survey
current
state
intervention,
a
focus
on
forthcoming
promising
chimeric
antigen
receptor
(CAR)
T
sets
major
obstacles
CAR-T
therapies,
creating
conditions
that
suppress
response,
inducing
exhaustion.
To
enhance
efficacy,
specific
efforts
associated
NSCLC,
should
definitely
TME-related
immunosuppression
escape
by
combining
blockades.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 8, 2025
Chimeric
antigen
receptor
(CAR)-T
cell
therapy
represents
a
promising
strategy
for
cancer
treatment.
However,
the
diversity
of
solid
tumor
antigens
and
poor
infiltration
CAR-T
cells
significantly
hinder
efficacy
therapies
against
tumors.
Here,
spatially
distributed
microneedle
system
(SDMNS)
is
developed
that
leverages
bioorthogonal
reactions
to
activate
guide
endogenous
T
tumors
effective
destruction.
The
SDMNS
consists
two
dissolving
microneedles,
each
loaded
with
complementary
groups
applied
separately
lymph
nodes
sites.
One
dibenzocyclooctyne
(DBCO)-modified
antibodies
activates
labels
them
in
nodes.
other
microneedle,
containing
N-azidoacetylmannosamine-tetraacylated
(Ac4ManNAz)
glycometabolic
labeling
cells,
chemotactic
factor
IP10,
directly
site.
vivo
studies
demonstrate
effectively
directs
migration
activated
into
Through
click
reaction,
DBCO-modified
conjugate
azide
(N3)-modified
eliciting
robust
antitumor
immune
responses
durable
memory.
offers
novel
overcomes
heterogeneity
by
facilitating
directed
cells.
Zentralblatt für Chirurgie - Zeitschrift für Allgemeine Viszeral- Thorax- und Gefäßchirurgie,
Год журнала:
2025,
Номер
150(02), С. 170 - 174
Опубликована: Апрель 1, 2025
Zusammenfassung
Im
Vergleich
zu
früheren
Behandlungsstandards
(einschl.
Chemotherapie,
Strahlentherapie
und
Chirurgie)
hat
die
Immuntherapie
bedeutende
Verbesserungen
für
Patienten
in
Bezug
auf
Überleben
Lebensqualität
gebracht.
ist
letztlich
eine
Art
Sammelbegriff
Vielzahl
unterschiedlichster
Therapeutika.
Immuntherapeutische
Ansätze
haben
sich
fest
als
ein
neuer
Pfeiler
der
Krebsversorgung
etabliert,
von
den
neoadjuvanten
adjuvanten
Ansätzen
bis
hin
zur
metastatischen
Phase
bei
diversen
Entitäten.
In
diesem
Review-Artikel
heben
wir
hervor,
welche
Immuntherapien
heutzutage
onkologischen
Versorgung
Standard
sind,
mit
einem
starken
Fokus
Immuncheckpoint-Inhibitoren
(ICIs),
deren
Einschränkungen
sowie
häufig
auftretenden
Nebenwirkungen.
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 15, 2024
Chimeric
antigen
receptor
(CAR)
T-cell
therapy
is
a
revolutionary
development
in
the
field
of
cancer
immunotherapy,
offering
targeted
approach
to
combat
various
hematologic
malignancies.
In
this
treatment,
patient’s
genetically
modified
T
cells
are
extracted
and
transformed
produce
chimeric
receptors
(CARs)
that
exclusive
cells.
These
altered
identify,
attach
to,
destroy
when
they
reinfused
back
into
patient,
customized
course
therapy.
While
CAR
therapy’s
clinical
success
has
been
most
evident
cases
acute
lymphoblastic
leukemia
certain
types
lymphomas,
ongoing
research
aims
extend
its
applicability
solid
tumors.
Despite
promise,
challenges
like
cytokine
release
syndrome
high
cost
treatment
remain.
Nonetheless,
heralds
new
era
potentially
curative
for
patients
with
otherwise
refractory
diseases.
Communications Biology,
Год журнала:
2024,
Номер
7(1)
Опубликована: Ноя. 9, 2024
As
a
newly
defined
type
of
programmed
cell
death,
ferroptosis
is
considered
potent
weapon
against
tumors
due
to
its
distinct
mechanism
from
other
types
death.
Ferroptosis
triggered
by
the
uncontrolled
accumulation
hydroperoxyl
polyunsaturated
fatty
acid-containing
phospholipids,
also
called
lipid
peroxidation.
The
peroxidation,
generated
through
enzymatic
and
non-enzymatic
mechanisms,
drives
changes
in
morphology
destruction
membrane
integrity.
Here,
we
dissect
mechanisms
induced
enzymatically
or
non-enzymatically,
summarize
major
metabolism
pathways
modulating
provide
insights
into
relationship
between
tumor
suppression.
In
this
review,
discuss
recent
advances
microenvironments
prospect
potential
therapeutic
application.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 5, 2024
Breast
cancer,
one
of
the
most
prevalent
malignancies
among
women
worldwide,
has
rising
incidence
rates.
Physical
activity,
particularly
exercise,
emerged
as
a
significant
modifier
cancer
prognosis,
influencing
both
tumor
biology
and
patient
outcomes.
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
21(11), С. 5864 - 5879
Опубликована: Окт. 8, 2024
Despite
the
advancements
in
cancer
therapy,
delivering
active
pharmaceutical
ingredients
(APIs)
using
nanoparticles
remains
challenging
due
to
failed
conveyance
of
required
drug
payload,
poor
targeting
ability,
and
biodistribution,
hampering
their
clinical
translation.
Recently,
appropriate
design
materials
with
intrinsic
therapeutic
functionalities
has
garnered
enormous
interest
development
various
intelligent
nanoplatforms.
In
this
study,
we
demonstrate
fabrication
transition
metal
(molybdenum,
Mo)-doped
manganese
dioxide
(MnO2)
nanoarchitectures,
exhibiting
diagnostic
(magnetic
resonance
imaging,
MRI)
(chemodynamic
CDT)
functionalities.
The
facile
hydrothermal
approach-assisted
Mo-doped
MnO2
flower-like
nanostructures
offered
tailorable
morphologies
altered
dimensions,
precise
effects,
exceptional
biocompatibility,
biodegradability
tumor
microenvironment.
resultant
defects
doped
Mo
species
exhibited
peroxidase
oxidase
activities,
improving
glutathione
(GSH)
oxidation.
two
sets
variable
valence
ion
pairs
(Mn2+/Mn4+
Mo5+/Mo6+)
interplay
could
substantially
improve
Fenton-like
reaction
generate
toxic
hydroxyl
radicals
(•OH),
thus
achieving
CDT-assisted
antitumor
effects.
As
inherent
T1-MRI
agents,
these
displayed
excellent
MRI
efficacy
vitro.
Together,
believe
that
conformational
nanoarchitectures
states
potentiate
drugless
therapy
pharmaceutics.
Molecular Biomedicine,
Год журнала:
2024,
Номер
5(1)
Опубликована: Окт. 30, 2024
Abstract
Systemic
lupus
erythematosus
(SLE)
is
a
multifaceted
autoimmune
disorder
characterized
by
dysregulated
immune
responses
and
autoantibody
production,
which
affects
multiple
organs
varies
in
clinical
presentation
disease
severity.
The
development
of
SLE
intricate,
encompassing
dysregulation
within
the
system,
collapse
immunological
tolerance,
genetic
susceptibilities
to
disease,
variety
environmental
factors
that
can
act
as
triggers.
This
review
provides
comprehensive
discussion
pathogenesis
treatment
strategies
focuses
on
progress
status
traditional
emerging
for
SLE.
Traditional
have
mainly
employed
non-specific
approaches,
including
cytotoxic
immunosuppressive
drugs,
antimalarials,
glucocorticoids,
NSAIDs.
These
are
effective
mitigating
effects
but
they
not
complete
cure
often
accompanied
adverse
reactions.
Emerging
targeted
therapeutic
other
hand,
aim
control
treat
targeting
B
T
cells,
inhibiting
their
activation
function,
well
abnormal
system.
A
deeper
understanding
exploration
new
essential
advance
this
complex
disease.