Human Genomics, Journal Year: 2025, Volume and Issue: 19(1)
Published: Feb. 21, 2025
Language: Английский
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 10, 2025
Thermoelectric therapy has been emerging as a promising and versatile strategy for targeting malignant tumors treatment. However, the lack of effective time-space controlled triggering thermoelectric effect in vivo limits application therapy. Here magnetically triggered heterojunction (CuFe2O4/SrTiO3, CFO/STO) synergistic thermoelectric/chemodynamic/immuno-therapy is developed. The efficient magnetothermal nanoagent (CFO) synthesized using hydrothermal method, nanomaterials (STO) are grown on its surface to create heterojunction. To enhance oral delivery efficiency, fusion membrane (M) Staphylococcus aureus macrophage cell membranes coated CFO/STO heterojunction, enabling orthotopic colorectal cancer. Once CFO/STO@M reaches tumor region, vitro alternating magnetic field (AMF) stimulation activates catalytic treatment through magnetic-thermo-electric energy cascade conversion effect. Additionally, immunogenic death cells, down-regulating vascular endothelial growth factor heat shock protein HSP70, increasing expression adhesion molecule (ICAM-1/VCAM-1), M1 polarization macrophages contribute immunotherapy. Overall, based shows remarkable antitumor capability female mice, offering approach broaden both scope effectiveness cancer treatment, but limited by spatiotemporal control vivo. Here, authors report spatiotemporally controllable nanodevice that allows precise mediate thermoelectric/chemodynamic/immunotherapy
Language: Английский
Citations
1
Zentralblatt für Chirurgie - Zeitschrift für Allgemeine Viszeral- Thorax- und Gefäßchirurgie, Journal Year: 2025, Volume and Issue: 150(02), P. 170 - 174
Published: April 1, 2025
Zusammenfassung Im Vergleich zu früheren Behandlungsstandards (einschl. Chemotherapie, Strahlentherapie und Chirurgie) hat die Immuntherapie bedeutende Verbesserungen für Patienten in Bezug auf Überleben Lebensqualität gebracht. ist letztlich eine Art Sammelbegriff Vielzahl unterschiedlichster Therapeutika. Immuntherapeutische Ansätze haben sich fest als ein neuer Pfeiler der Krebsversorgung etabliert, von den neoadjuvanten adjuvanten Ansätzen bis hin zur metastatischen Phase bei diversen Entitäten. In diesem Review-Artikel heben wir hervor, welche Immuntherapien heutzutage onkologischen Versorgung Standard sind, mit einem starken Fokus Immuncheckpoint-Inhibitoren (ICIs), deren Einschränkungen sowie häufig auftretenden Nebenwirkungen.
Citations
1
Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102286 - 102286
Published: May 6, 2024
Language: Английский
Citations
8
BioChip Journal, Journal Year: 2024, Volume and Issue: 18(2), P. 211 - 232
Published: April 3, 2024
Language: Английский
Citations
5
IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: May 15, 2024
Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary development in the field of cancer immunotherapy, offering targeted approach to combat various hematologic malignancies. In this treatment, patient’s genetically modified T cells are extracted and transformed produce chimeric receptors (CARs) that exclusive cells. These altered identify, attach to, destroy when they reinfused back into patient, customized course therapy. While CAR therapy’s clinical success has been most evident cases acute lymphoblastic leukemia certain types lymphomas, ongoing research aims extend its applicability solid tumors. Despite promise, challenges like cytokine release syndrome high cost treatment remain. Nonetheless, heralds new era potentially curative for patients with otherwise refractory diseases.
Language: Английский
Citations
5
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 5, 2024
Breast cancer, one of the most prevalent malignancies among women worldwide, has rising incidence rates. Physical activity, particularly exercise, emerged as a significant modifier cancer prognosis, influencing both tumor biology and patient outcomes.
Language: Английский
Citations
4
Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(11), P. 5864 - 5879
Published: Oct. 8, 2024
Despite the advancements in cancer therapy, delivering active pharmaceutical ingredients (APIs) using nanoparticles remains challenging due to failed conveyance of required drug payload, poor targeting ability, and biodistribution, hampering their clinical translation. Recently, appropriate design materials with intrinsic therapeutic functionalities has garnered enormous interest development various intelligent nanoplatforms. In this study, we demonstrate fabrication transition metal (molybdenum, Mo)-doped manganese dioxide (MnO2) nanoarchitectures, exhibiting diagnostic (magnetic resonance imaging, MRI) (chemodynamic CDT) functionalities. The facile hydrothermal approach-assisted Mo-doped MnO2 flower-like nanostructures offered tailorable morphologies altered dimensions, precise effects, exceptional biocompatibility, biodegradability tumor microenvironment. resultant defects doped Mo species exhibited peroxidase oxidase activities, improving glutathione (GSH) oxidation. two sets variable valence ion pairs (Mn2+/Mn4+ Mo5+/Mo6+) interplay could substantially improve Fenton-like reaction generate toxic hydroxyl radicals (•OH), thus achieving CDT-assisted antitumor effects. As inherent T1-MRI agents, these displayed excellent MRI efficacy vitro. Together, believe that conformational nanoarchitectures states potentiate drugless therapy pharmaceutics.
Language: Английский
Citations
4
Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)
Published: Oct. 30, 2024
Abstract Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder characterized by dysregulated immune responses and autoantibody production, which affects multiple organs varies in clinical presentation disease severity. The development of SLE intricate, encompassing dysregulation within the system, collapse immunological tolerance, genetic susceptibilities to disease, variety environmental factors that can act as triggers. This review provides comprehensive discussion pathogenesis treatment strategies focuses on progress status traditional emerging for SLE. Traditional have mainly employed non-specific approaches, including cytotoxic immunosuppressive drugs, antimalarials, glucocorticoids, NSAIDs. These are effective mitigating effects but they not complete cure often accompanied adverse reactions. Emerging targeted therapeutic other hand, aim control treat targeting B T cells, inhibiting their activation function, well abnormal system. A deeper understanding exploration new essential advance this complex disease.
Language: Английский
Citations
4
Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)
Published: Nov. 9, 2024
As a newly defined type of programmed cell death, ferroptosis is considered potent weapon against tumors due to its distinct mechanism from other types death. Ferroptosis triggered by the uncontrolled accumulation hydroperoxyl polyunsaturated fatty acid-containing phospholipids, also called lipid peroxidation. The peroxidation, generated through enzymatic and non-enzymatic mechanisms, drives changes in morphology destruction membrane integrity. Here, we dissect mechanisms induced enzymatically or non-enzymatically, summarize major metabolism pathways modulating provide insights into relationship between tumor suppression. In this review, discuss recent advances microenvironments prospect potential therapeutic application.
Language: Английский
Citations
4
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 127 - 146
Published: Jan. 1, 2025
Language: Английский
Citations
0