Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(16)
Опубликована: Апрель 2, 2024
Atherosclerotic
plaque
formation
is
considered
the
primary
pathological
mechanism
underlying
atherosclerotic
cardiovascular
diseases,
leading
to
severe
events
such
as
stroke,
acute
coronary
syndromes,
and
even
sudden
cardiac
death.
Early
detection
timely
intervention
of
plaques
are
challenging
due
lack
typical
symptoms
in
initial
stages.
Therefore,
precise
early
play
a
crucial
role
risk
stratification
achieving
favorable
post-interventional
outcomes.
The
continuously
advancing
nanoplatforms
have
demonstrated
numerous
advantages
including
high
signal-to-noise
ratio,
enhanced
bioavailability,
specific
targeting
capabilities
for
imaging
agents
therapeutic
drugs,
enabling
effective
visualization
management
plaques.
Motivated
by
these
superior
properties,
various
noninvasive
modalities
recognition
preliminary
stage
atherosclerosis
comprehensively
summarized.
Additionally,
several
strategies
proposed
enhance
efficacy
treating
Finally,
existing
challenges
promising
prospects
accelerating
clinical
translation
nanoplatform-based
molecular
therapy
discussed.
In
conclusion,
this
review
provides
an
insightful
perspective
on
diagnosis
Advanced Materials,
Год журнала:
2022,
Номер
34(39)
Опубликована: Авг. 12, 2022
Extensive
efforts
are
devoted
to
refining
metal
sites
for
optimizing
the
catalytic
performance
of
single-atom
nanozymes
(SANzymes),
while
contribution
defect
environment
neighboring
lacks
attention.
Herein,
an
iron-based
SANzyme
(Fe-SANzyme)
is
rationally
designed
by
edge-site
engineering,
which
intensively
exposes
edge-hosted
defective
Fe-N4
atomic
anchored
in
hierarchical
mesoporous
structures.
The
Fe-SANzyme
exhibits
excellent
catalase-like
activity
capable
efficiently
catalyzing
decomposition
H2
O2
into
and
O,
with
a
kinetic
KM
value
superior
that
natural
catalase
reported
nanozymes.
mechanistic
studies
depict
defects
introduce
notable
charge
transfer
from
Fe
atom
carbon
matrix,
making
central
more
activated
strengthen
interaction
weaken
OO
bond.
By
performing
catalysis,
significantly
scavenges
reactive
oxygen
species
(ROS)
alleviates
oxidative
stress,
thus
eliminating
pathological
angiogenesis
animal
models
retinal
vasculopathies
without
affecting
repair
normal
vessels.
This
work
provides
new
way
refine
SANzymes
engineering
geometric
structure
around
sites,
demonstrates
potential
therapeutic
effects
nanozyme
on
vasculopathies.
Abstract
Nanozymes
are
nanomaterials
with
similar
catalytic
activities
to
natural
enzymes.
Compared
enzymes,
they
have
numerous
advantages,
including
higher
physiochemical
stability,
versatility,
and
suitability
for
mass
production.
In
the
past
decade,
synthesis
of
nanozymes
their
mechanisms
advanced
beyond
simple
replacement
allowing
fascinating
applications
in
various
fields
such
as
biosensing
disease
treatment.
particular,
exploration
powerful
toolkits
diagnostic
viral
testing
antiviral
therapy
has
attracted
growing
attention.
It
can
address
great
challenges
faced
by
current
enzyme‐based
technologies,
high
cost
storage
difficulties.
Therefore,
nanozyme
provide
a
novel
nanozyme‐based
therapeutic
regime
broader
availability
generalizability
that
keys
fighting
pandemic
COVID‐19.
Herein,
we
timely
review
state‐of‐the‐art
regarding
activities,
well
focused
discussion
on
recent
research
into
use
therapy.
The
remaining
future
perspectives
will
also
be
outlined.
Ultimately,
this
inform
readers
knowledge
inspire
more
innovative
studies
push
forward
frontier
field.
Advanced Materials,
Год журнала:
2023,
Номер
36(10)
Опубликована: Фев. 2, 2023
Ischemic
stroke
(IS)
is
one
of
the
most
common
causes
disability
and
death.
Thrombolysis
neuroprotection
are
two
current
major
therapeutic
strategies
to
overcome
ischemic
reperfusion
damage.
In
this
work,
a
novel
peptide-templated
manganese
dioxide
nanozyme
(PNzyme/MnO
ACS Nano,
Год журнала:
2022,
Номер
16(10), С. 15959 - 15976
Опубликована: Окт. 11, 2022
Atherosclerosis,
driven
by
chronic
inflammation
in
the
artery
walls,
underlies
several
severe
cardiovascular
diseases.
However,
currently
available
anti-inflammatory-based
strategies
for
atherosclerosis
treatment
suffer
from
compromised
therapeutic
efficacy
and
undesirable
outcome.
Herein,
a
distinct
tetrapod
needle-like
PdH
nanozyme
was
designed
engineered
efficient
combinatorial
reactive
oxygen
species
(ROS)
scavenging,
hydrogen
anti-inflammation,
autophagy
activation.
After
loading
into
macrophages
targeted
delivery
to
arterial
plaques,
these
multifunctional
nanozymes
efficiently
decreased
ROS
levels
significantly
suppressed
inflammation-related
pathological
process,
exerting
antioxidation
anti-inflammatory
performance
alleviating
development.
Especially
importantly,
specific
spiky
morphology
of
nanoenzyme
further
triggered
strong
response
macrophages,
synergistically
maintaining
cellular
homeostasis
Both
vitro
vivo
results
confirmed
synergy
among
antioxidation,
anti-inflammatory,
activation,
suggesting
that
engineering
nanomedicines
with
intrinsic
multiple
functions
topology-induced
biological
effects
is
highly
preferable
effective
achieving
high
desirable
outcome
on
management
therapy.
Abstract
Nanozymes
refer
to
nanomaterials
that
catalyze
enzyme
substrates
into
products
under
relevant
physiological
conditions
following
kinetics.
Compared
natural
enzymes,
nanozymes
possess
the
characteristics
of
higher
stability,
easier
preparation,
and
lower
cost.
Importantly,
magnetic,
fluorescent,
electrical
properties
nanomaterials,
making
them
promising
replacements
for
enzymes
in
industrial,
biological,
medical
fields.
On
account
rapid
development
recently,
their
application
potentials
regeneration
medicine
are
gradually
being
explored.
To
highlight
achievements
field,
this
review
summarizes
catalytic
mechanism
four
types
representative
nanozymes.
Then,
strategies
improve
biocompatibility
discussed.
covers
recent
advances
tissue
including
wound
healing,
nerve
defect
repair,
bone
regeneration,
cardiovascular
disease
treatment.
In
addition,
challenges
prospects
nanozyme
researches
summarized.
Metal-organic
frameworks
(MOFs)
are
composed
of
metal
nodes
and
organic
linkers
that
can
self-assemble
into
an
infinite
network.
The
high
porosity
large
surface
area
MOFs
facilitate
the
effective
enrichment
mass
transfer
analytes,
which
enhance
signal
response
improve
sensitivity
electrochemical
sensors.
Additionally,
their
derivatives
possess
properties
unsaturated
sites
tunable
structures,
collectively
demonstrating
potential
for
sensing.
This
paper
summarizes
preparation
methods,
structural
properties,
applications
in
sensing,
emphasizing
sensors'
selectivity
from
perspectives
direct
indirect
detection.
it
also
explores
future
directions
prospects
with
aim
overcoming
current
limitations
through
innovative
approaches.
