Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(9)
Опубликована: Янв. 12, 2024
With the rapid development of external minimally invasive or noninvasive therapeutic modalities, ultrasound-based sonodynamic therapy (SDT) is a new alternative for treating deep tumors. However, inadequate sonosensitizer efficiency and poor biosecurity limit clinical applications. In this study, we prepared an oxygen-vacancy-engineered W
Язык: Английский
Exploration, Год журнала: 2021, Номер 1(3)
Опубликована: Дек. 1, 2021
Bioactive materials are a kind of with unique bioactivities, which can change the cellular behaviors and elicit biological responses from living tissues. came into spotlight in late 1960s when researchers found that such as bioglass could react surrounding bone tissue for regeneration. In following decades, advances nanotechnology brought new development opportunities to bioactive nanomaterials. nanomaterials not simple miniaturization macroscopic materials. They exhibit bioactivities due their nanoscale size effect, high specific surface area, precise nanostructure, significantly influence interactions systems. Nowadays, have represented an important exciting area research. Current future applications ensure academic clinical importance. This review summaries recent field nanomaterials, evaluate factors bioactivities. Then, range potential biomedical discussed. Furthermore, limitations, challenges, also
Язык: Английский
Процитировано
267
Advanced Science, Год журнала: 2022, Номер 10(2)
Опубликована: Ноя. 24, 2022
Diabetic foot ulcers (DFU), one of the most serious complications diabetes, are essentially chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Given its pathogenesis, DFU microenvironment is rather complicated characterized hyperglycemia, ischemia, hypoxia, hyperinflammation, persistent However, current clinical therapies for dissatisfactory, which drives researchers to turn attention advanced nanotechnology address therapeutic bottlenecks. In last decade, a large number multifunctional nanosystems based on have been developed with positive effects in therapy, forming novel concept "DFU nanomedicine". systematic overview nanomedicine still unavailable literature. This review summarizes microenvironmental characteristics DFU, presents main progress wound healing, summaries state-of-the-art strategies DFU. Furthermore, challenges future perspectives this field discussed prospected, aiming fuel foster development nanomedicines successfully.
Язык: Английский
Процитировано
214
Chemical Society Reviews, Год журнала: 2023, Номер 52(6), С. 2031 - 2081
Опубликована: Янв. 1, 2023
Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication
Язык: Английский
Процитировано
137
Advanced Materials, Год журнала: 2022, Номер 34(41)
Опубликована: Авг. 20, 2022
Clinical immunotherapy of solid tumors elicits durable responses only in a minority patients, largely due to the highly immunosuppressive tumor microenvironment (TME). Although rational combinations vaccine adjuvants with inflammatory cytokines or immune agonists that relieve immunosuppression represent an appealing therapeutic strategy against tumors, there are unavoidable nonspecific toxicities pleiotropy and undesired activation off-target cells. Herein, Zn2+ doped layered double hydroxide (Zn-LDH) based immunomodulating adjuvant, which not relieves but also robust antitumor immunity, is reported. Peritumorally injected Zn-LDH sustainably neutralizes acidic TME releases abundant , promoting pro-inflammatory network composed M1-tumor-associated macrophages, cytotoxic T cells, natural-killer Moreover, internalized by cells effectively disrupts endo-/lysosomes block autophagy induces mitochondrial damage, released activates cGas-STING signaling pathway induce immunogenic cell death, further promotes release tumor-associated antigens antigen-specific lymphocytes. Unprecedentedly, merely injection without using any agonists, significantly inhibits growth, recurrence, metastasis mice. This study provides bottom-up design potent adjuvant for cancer metalloimmunotherapy tumors.
Язык: Английский
Процитировано
123
Bioactive Materials, Год журнала: 2022, Номер 18, С. 446 - 458
Опубликована: Март 29, 2022
Язык: Английский
Процитировано
100
Exploration, Год журнала: 2022, Номер 2(4)
Опубликована: Апрель 19, 2022
Glioblastoma (GBM) is a central nervous system tumor with poor prognosis due to the rapid development of resistance mono chemotherapy and brain targeted delivery. Chemoimmunotherapy (CIT) combines drugs activators innate immunity that hold great promise for GBM synergistic therapy. Herein, we chose temozolomide, TMZ, epigenetic bromodomain inhibitor, OTX015, further co-encapsulated them within our well-established erythrocyte membrane camouflaged nanoparticle yield ApoE peptide decorated biomimetic nanomedicine (ABNM@TMZ/OTX). Our nanoplatform successfully addressed limitations in brain-targeted drug co-delivery, simultaneously achieved multidimensional enhanced CIT. In mice bearing orthotopic GL261 GBM, treatment ABNM@TMZ/OTX resulted marked inhibition greatly extended survival time little side effects. The pronounced efficacy can be ascribed three key factors: (i) improved nanoparticle-mediated targeting delivery therapeutic agents by blood circulation blood-brain barrier penetration; (ii) inhibited cellular DNA repair TMZ sensitivity cells; (iii) anti-tumor immune responses inducing immunogenic cell death inhibiting PD-1/PD-L1 conjugation leading expression CD4
Язык: Английский
Процитировано
96
Biomaterials Science, Год журнала: 2022, Номер 10(15), С. 4058 - 4076
Опубликована: Янв. 1, 2022
Multifunctional wound dressings or smart with pro-angiogenic function, antibacterial properties, anti-inflammatory/antioxidant activity and tissue adhesion for chronic repair.
Язык: Английский
Процитировано
95
Small Methods, Год журнала: 2022, Номер 6(11)
Опубликована: Окт. 6, 2022
Abstract Nanozymes refer to nanomaterials that catalyze enzyme substrates into products under relevant physiological conditions following kinetics. Compared natural enzymes, nanozymes possess the characteristics of higher stability, easier preparation, and lower cost. Importantly, magnetic, fluorescent, electrical properties nanomaterials, making them promising replacements for enzymes in industrial, biological, medical fields. On account rapid development recently, their application potentials regeneration medicine are gradually being explored. To highlight achievements field, this review summarizes catalytic mechanism four types representative nanozymes. Then, strategies improve biocompatibility discussed. covers recent advances tissue including wound healing, nerve defect repair, bone regeneration, cardiovascular disease treatment. In addition, challenges prospects nanozyme researches summarized.
Язык: Английский
Процитировано
90
Materials Today, Год журнала: 2023, Номер 62, С. 296 - 326
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
85
ACS Nano, Год журнала: 2023, Номер 17(7), С. 6789 - 6799
Опубликована: Март 29, 2023
Single-atom catalysts with extraordinary catalytic activity have been receiving great attention in tumor therapy. However, most single-atom lack self-propulsion properties, restricting them from actively approaching cancer cells or penetrating the interior of tumors. Herein, we design N-doped jellyfish-like mesoporous carbon nanomotors coordinated copper (Cu-JMCNs). It is a combination nanocatalytic medicine and nanomotor for The Cu single atom can catalyze H2O2 into toxic hydroxyl radical (•OH) chemodynamic therapy (CDT). Near-infrared light triggers Cu-JMCNs to achieve self-thermophoretic motion because asymmetric structure photothermal property carbon, which significantly improves cellular uptake penetration three-dimensional In vivo experiments indicate that CDT near-infrared propulsion over 85% inhibition rate. This work sheds on development advanced biomedical applications.
Язык: Английский
Процитировано
84