Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications

Advanced Materials, Год журнала: 2023, Номер 35(25)

Опубликована: Янв. 12, 2023

Abstract Emerging piezocatalysts have demonstrated their remarkable application potential in diverse medical fields. In addition to ultrahigh catalytic activities, inherent and unique charge‐carrier‐releasing properties can be used initiate various redox reactions, displaying bright prospects for future applications. Triggered by mechanical energy, piezocatalytic materials release electrons/holes, catalyze reactions of substrates, or intervene biological processes promote the production effector molecules purposes, such as decontamination, sterilization, therapy. Such a piezocatalysis is termed medicine (PCM) herein. To pioneer novel technologies, especially therapeutic modalities, this review provides an overview state‐of‐the‐art research progress medicine. First, principle preparation methodologies piezoelectric are introduced. Then, comprehensive summary applications tumor treatment, antisepsis, organic degradation, tissue repair regeneration, biosensing provided. Finally, main challenges perspectives discussed proposed, expecting fuel development emerging scientific discipline.

Язык: Английский

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An Immunomodulatory Hydrogel by Hyperthermia‐Assisted Self‐Cascade Glucose Depletion and ROS Scavenging for Diabetic Foot Ulcer Wound Therapeutics

Advanced Materials, Год журнала: 2023, Номер 35(48)

Опубликована: Окт. 7, 2023

Abstract Current therapeutic protocols for diabetic foot ulcers (DFUs), a severe and rapidly growing chronic complication in patients, remain nonspecific. Hyperglycemia‐caused inflammation excessive reactive oxygen species (ROS) are common obstacles encountered DFU wound healing, often leading to impaired recovery. These two effects reinforce each other, forming an endless loop. However, adequate inclusive methods still lacking target these aspects break the vicious cycle. This study proposes novel approach treating wounds, utilizing immunomodulatory hydrogel achieve self‐cascade glucose depletion ROS scavenging regulate microenvironment. Specifically, AuPt@melanin‐incorporated (GHM3) dressing is developed facilitate efficient hyperthermia‐enhanced local scavenging. Mechanistically, vitro/vivo experiments RNA sequencing analysis demonstrate that GHM3 disrupts ROS‐inflammation cascade cycle downregulates ratio of M1/M2 macrophages, consequently improving outcomes dorsal skin wounds rats. In conclusion, this proposed offers facile, safe, highly treatment modality DFUs.

Язык: Английский

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Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine

Advanced Science, Год журнала: 2022, Номер 10(2)

Опубликована: Ноя. 24, 2022

Diabetic foot ulcers (DFU), one of the most serious complications diabetes, are essentially chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Given its pathogenesis, DFU microenvironment is rather complicated characterized hyperglycemia, ischemia, hypoxia, hyperinflammation, persistent However, current clinical therapies for dissatisfactory, which drives researchers to turn attention advanced nanotechnology address therapeutic bottlenecks. In last decade, a large number multifunctional nanosystems based on have been developed with positive effects in therapy, forming novel concept "DFU nanomedicine". systematic overview nanomedicine still unavailable literature. This review summarizes microenvironmental characteristics DFU, presents main progress wound healing, summaries state-of-the-art strategies DFU. Furthermore, challenges future perspectives this field discussed prospected, aiming fuel foster development nanomedicines successfully.

Язык: Английский

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Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

Military Medical Research, Год журнала: 2023, Номер 10(1)

Опубликована: Авг. 22, 2023

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating due to their excellent hydrophilicity, good drug-loading ability sustained drug release properties. As typical example, hyaluronic acid dressing (Healoderm) has been demonstrated clinical trials improve wound-healing efficiency healing rates foot ulcers. However, the degradation behavior clinically-used cannot adjusted according microenvironment. Due intricacy wounds, antibiotics other medications are frequently combined with practice, although these easily hindered by hostile environment. In this case, scientists created responsive-hydrogel based on microenvironment features (such as high glucose low pH) or external stimuli light magnetic field) achieve controllable release, gel degradation, improvements order overcome issues. These anticipated play significant role therapeutic dressings. Here, we review recent advances towards healing, focus structure design, principle responsiveness, degradation. Last but not least, advantages limitations responsive-hydrogels applications will also discussed. We hope contribute furthering progress hydrogels improved practical application.

Язык: Английский

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Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing

ACS Nano, Год журнала: 2023, Номер 17(16), С. 15962 - 15977

Опубликована: Авг. 3, 2023

Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic carbon nitride nanosheets (ACPCAH). This possesses five types enzyme-like activities, including superoxide dismutase (SOD)-, catalase (CAT)-, glucose oxidase (GOx)-, peroxidase (POD)-, nitric oxide synthase (NOS)-like activities. The kinetics reaction mechanism sonodynamic/sonothermal synergistic enhancement SOD-CAT-GOx-POD/NOS cascade ACPCAH are fully investigated. Both in vitro vivo tests demonstrate that this can be activated thus accelerating wound healing effectively. study highlights a competitive approach based on nanozymes for development all-in-one therapies.

Язык: Английский

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An Immunoregulation Hydrogel with Controlled Hyperthermia‐Augmented Oxygenation and ROS Scavenging for Treating Diabetic Foot Ulcers

Advanced Functional Materials, Год журнала: 2024, Номер 34(33)

Опубликована: Май 6, 2024

Abstract Diabetic foot ulcers (DFUs), a serious and increasingly common chronic issue among diabetics, often do not respond well to generalized treatment strategies. Hypoxia the overexpression of reactive oxygen species (ROS), resulting in inflammatory dysregulation subsequent imbalance macrophage phenotypes, are critical factors contributing prolonged non‐healing DFU wounds. These two issues interact continuous, problematic cycle. Presently, there is lack comprehensive strategies aimed at addressing both these simultaneously interrupt this detrimental Herein, an immunomodulatory hydrogel (PHG2) developed for reshaping hostile microenvironment. The engineered PHG2 only removes excess internally‐produced ROS but also generates O 2 , with its efficiency further boosted by local hyperthermia (42.5 °C) activated near‐infrared light. Through vitro vivo studies, along transcriptomic assessment, it confirmed that disrupts feedback loop between inflammation while lowering M1/M2 ratio. Such discoveries contribute significant enhancement healing process injuries undergo gradual increase movement, covering wounds from back, mouth, foot. Ultimately, method provides easy, safe, highly effective solution treating DFUs.

Язык: Английский

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H2S-releasing versatile hydrogel dressing with potent antimicrobial, anti-inflammatory, epithelialization and angiogenic capabilities for diabetic wound healing

Chemical Engineering Journal, Год журнала: 2023, Номер 469, С. 143985 - 143985

Опубликована: Июнь 7, 2023

Язык: Английский

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Single-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Окт. 25, 2023

Psoriasis is a common inflammatory disease of especially high recurrence rate (90%) which suffered by approximately 3% the world population. The overexpression reactive oxygen species (ROS) plays critical role in psoriasis progress. Here we show that biomimetic iron single-atom catalysts (FeN4O2-SACs) with broad-spectrum ROS scavenging capability can be used for treatment and relapse prevention via related gene restoration. FeN4O2-SACs demonstrate attractive multiple enzyme-mimicking activities based on atomically dispersed Fe active structures, are analogous to those natural antioxidant enzymes, superoxide dismutase, human erythrocyte catalase, ascorbate peroxidase. Further, vitro vivo experiments effectively ameliorate psoriasis-like symptoms prevent augmented efficacy compared clinical drug calcipotriol. Mechanistically, estrogen receptor 1 (ESR1) identified as core protein upregulated through RNA sequencing bioinformatic analysis. Together, this study provides proof concept catalytic therapy (PCT) multienzyme-inspired bionics (MIB).

Язык: Английский

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The Unprecedented Biodegradable Polyzwitterion: A Removal‐Free Patch for Accelerating Infected Diabetic Wound Healing

Advanced Materials, Год журнала: 2024, Номер 36(30)

Опубликована: Май 12, 2024

Zwitterionic polymers have emerged as an important class of biomaterials to construct wound dressings and antifouling coatings over the past decade due their excellent hydrophilicity. However, all reported zwitterionic are nondegradable because noncleavable carbon─carbon bonding backbones, must be removed periodically after treatment avoid hypoxia in wound, thus leading potential secondary injury. In this work, a biodegradable polyzwitterion patch is fabricated for first time by ring-opening polymerization carboxybetaine dithiolane (CBDS), which self-crosslinked via inter-amide hydrogen bonds dipole-dipole interactions on side chains. The unprecedented polyCBDS (PCBDS) demonstrates enough ductility owing intermolecular physical fully cover irregular wounds, also showing biodegradability performance resulted from existence disulfide groups. Besides, PCBDS degradation-induced released CBDS owns potent antioxidant antibacterial activities. This used diabetic dressing, inhibiting bacterial adhesion external surface, its degradation products can exactly kill bacteria scavenge excessive reactive oxygen species (ROS) at site regulate local microenvironment, including regulation cytokine express macrophage polarization, accelerating infected repair, avoiding

Язык: Английский

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A Zn-MOF-GOx-based cascade nanoreactor promotes diabetic infected wound healing by NO release and microenvironment regulation

Acta Biomaterialia, Год журнала: 2024, Номер 182, С. 245 - 259

Опубликована: Май 9, 2024

Язык: Английский

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