Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(8)
Опубликована: Дек. 8, 2023
Abstract
Inducing
cell
migration
from
the
edges
to
center
of
a
wound,
promoting
angiogenesis,
and
controlling
bacterial
infection
are
very
important
for
diabetic
wound
healing.
Incorporating
growth
factors
antibiotics
into
hydrogels
dressing
is
considered
potential
strategy
meet
these
requirements.
However,
some
present
drawbacks
greatly
slow
down
their
development
toward
application,
such
as
short
half‐life
high
price
factors,
low
antibiotic
efficiency
against
drug‐resistant
bacteria,
insufficient
ability
promote
migration,
etc.
Deferoxamine
(DFO)
can
upregulate
expression
HIF‐1α,
thus
stimulating
secretion
angiogenesis‐related
endogenous
factors.
Copper
sulfide
(CuS)
nanoparticles
possess
excellent
antibacterial
performance
combined
with
photothermal
therapy
(PTT).
Herein,
DFO
CuS
incorporated
biomimetic
hydrogel,
which
mimics
structure
function
extracellular
matrix
(ECM),
abbreviated
DFO/CuS‐ECMgel.
This
hydrogel
expected
be
able
adhesion
degraded
by
cell‐secreted
metalloproteinases
(MMPs),
then
release
at
site
exert
therapeutic
effects.
As
result,
three
crucial
requirements
healing,
“beneficial
effectively
killing
bacteria,”
achieved
simultaneously.
Advanced Materials,
Год журнала:
2023,
Номер
35(25)
Опубликована: Янв. 12, 2023
Abstract
Emerging
piezocatalysts
have
demonstrated
their
remarkable
application
potential
in
diverse
medical
fields.
In
addition
to
ultrahigh
catalytic
activities,
inherent
and
unique
charge‐carrier‐releasing
properties
can
be
used
initiate
various
redox
reactions,
displaying
bright
prospects
for
future
applications.
Triggered
by
mechanical
energy,
piezocatalytic
materials
release
electrons/holes,
catalyze
reactions
of
substrates,
or
intervene
biological
processes
promote
the
production
effector
molecules
purposes,
such
as
decontamination,
sterilization,
therapy.
Such
a
piezocatalysis
is
termed
medicine
(PCM)
herein.
To
pioneer
novel
technologies,
especially
therapeutic
modalities,
this
review
provides
an
overview
state‐of‐the‐art
research
progress
medicine.
First,
principle
preparation
methodologies
piezoelectric
are
introduced.
Then,
comprehensive
summary
applications
tumor
treatment,
antisepsis,
organic
degradation,
tissue
repair
regeneration,
biosensing
provided.
Finally,
main
challenges
perspectives
discussed
proposed,
expecting
fuel
development
emerging
scientific
discipline.
Advanced Materials,
Год журнала:
2023,
Номер
35(48)
Опубликована: Окт. 7, 2023
Abstract
Current
therapeutic
protocols
for
diabetic
foot
ulcers
(DFUs),
a
severe
and
rapidly
growing
chronic
complication
in
patients,
remain
nonspecific.
Hyperglycemia‐caused
inflammation
excessive
reactive
oxygen
species
(ROS)
are
common
obstacles
encountered
DFU
wound
healing,
often
leading
to
impaired
recovery.
These
two
effects
reinforce
each
other,
forming
an
endless
loop.
However,
adequate
inclusive
methods
still
lacking
target
these
aspects
break
the
vicious
cycle.
This
study
proposes
novel
approach
treating
wounds,
utilizing
immunomodulatory
hydrogel
achieve
self‐cascade
glucose
depletion
ROS
scavenging
regulate
microenvironment.
Specifically,
AuPt@melanin‐incorporated
(GHM3)
dressing
is
developed
facilitate
efficient
hyperthermia‐enhanced
local
scavenging.
Mechanistically,
vitro/vivo
experiments
RNA
sequencing
analysis
demonstrate
that
GHM3
disrupts
ROS‐inflammation
cascade
cycle
downregulates
ratio
of
M1/M2
macrophages,
consequently
improving
outcomes
dorsal
skin
wounds
rats.
In
conclusion,
this
proposed
offers
facile,
safe,
highly
treatment
modality
DFUs.
Diabetic
foot
ulcers
(DFU),
one
of
the
most
serious
complications
diabetes,
are
essentially
chronic,
nonhealing
wounds
caused
by
diabetic
neuropathy,
vascular
disease,
and
bacterial
infection.
Given
its
pathogenesis,
DFU
microenvironment
is
rather
complicated
characterized
hyperglycemia,
ischemia,
hypoxia,
hyperinflammation,
persistent
However,
current
clinical
therapies
for
dissatisfactory,
which
drives
researchers
to
turn
attention
advanced
nanotechnology
address
therapeutic
bottlenecks.
In
last
decade,
a
large
number
multifunctional
nanosystems
based
on
have
been
developed
with
positive
effects
in
therapy,
forming
novel
concept
"DFU
nanomedicine".
systematic
overview
nanomedicine
still
unavailable
literature.
This
review
summarizes
microenvironmental
characteristics
DFU,
presents
main
progress
wound
healing,
summaries
state-of-the-art
strategies
DFU.
Furthermore,
challenges
future
perspectives
this
field
discussed
prospected,
aiming
fuel
foster
development
nanomedicines
successfully.
Military Medical Research,
Год журнала:
2023,
Номер
10(1)
Опубликована: Авг. 22, 2023
The
treatment
of
chronic
and
non-healing
wounds
in
diabetic
patients
remains
a
major
medical
problem.
Recent
reports
have
shown
that
hydrogel
wound
dressings
might
be
an
effective
strategy
for
treating
due
to
their
excellent
hydrophilicity,
good
drug-loading
ability
sustained
drug
release
properties.
As
typical
example,
hyaluronic
acid
dressing
(Healoderm)
has
been
demonstrated
clinical
trials
improve
wound-healing
efficiency
healing
rates
foot
ulcers.
However,
the
degradation
behavior
clinically-used
cannot
adjusted
according
microenvironment.
Due
intricacy
wounds,
antibiotics
other
medications
are
frequently
combined
with
practice,
although
these
easily
hindered
by
hostile
environment.
In
this
case,
scientists
created
responsive-hydrogel
based
on
microenvironment
features
(such
as
high
glucose
low
pH)
or
external
stimuli
light
magnetic
field)
achieve
controllable
release,
gel
degradation,
improvements
order
overcome
issues.
These
anticipated
play
significant
role
therapeutic
dressings.
Here,
we
review
recent
advances
towards
healing,
focus
structure
design,
principle
responsiveness,
degradation.
Last
but
not
least,
advantages
limitations
responsive-hydrogels
applications
will
also
discussed.
We
hope
contribute
furthering
progress
hydrogels
improved
practical
application.
ACS Nano,
Год журнала:
2023,
Номер
17(16), С. 15962 - 15977
Опубликована: Авг. 3, 2023
Treatment
of
diabetic
foot
ulcers
(DFU)
needs
to
reduce
inflammation,
relieve
hypoxia,
lower
blood
glucose,
promote
angiogenesis,
and
eliminate
pathogenic
bacteria,
but
the
therapeutic
efficacy
is
greatly
limited
by
diversity
synergy
drug
functions
as
well
DFU
microenvironment
itself.
Herein,
an
ultrasound-augmented
multienzyme-like
nanozyme
hydrogel
spray
was
developed
using
hyaluronic
acid
encapsulated
l-arginine
ultrasmall
gold
nanoparticles
Cu1.6O
coloaded
phosphorus
doped
graphitic
carbon
nitride
nanosheets
(ACPCAH).
This
possesses
five
types
enzyme-like
activities,
including
superoxide
dismutase
(SOD)-,
catalase
(CAT)-,
glucose
oxidase
(GOx)-,
peroxidase
(POD)-,
nitric
oxide
synthase
(NOS)-like
activities.
The
kinetics
reaction
mechanism
sonodynamic/sonothermal
synergistic
enhancement
SOD-CAT-GOx-POD/NOS
cascade
ACPCAH
are
fully
investigated.
Both
in
vitro
vivo
tests
demonstrate
that
this
can
be
activated
thus
accelerating
wound
healing
effectively.
study
highlights
a
competitive
approach
based
on
nanozymes
for
development
all-in-one
therapies.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(33)
Опубликована: Май 6, 2024
Abstract
Diabetic
foot
ulcers
(DFUs),
a
serious
and
increasingly
common
chronic
issue
among
diabetics,
often
do
not
respond
well
to
generalized
treatment
strategies.
Hypoxia
the
overexpression
of
reactive
oxygen
species
(ROS),
resulting
in
inflammatory
dysregulation
subsequent
imbalance
macrophage
phenotypes,
are
critical
factors
contributing
prolonged
non‐healing
DFU
wounds.
These
two
issues
interact
continuous,
problematic
cycle.
Presently,
there
is
lack
comprehensive
strategies
aimed
at
addressing
both
these
simultaneously
interrupt
this
detrimental
Herein,
an
immunomodulatory
hydrogel
(PHG2)
developed
for
reshaping
hostile
microenvironment.
The
engineered
PHG2
only
removes
excess
internally‐produced
ROS
but
also
generates
O
2
,
with
its
efficiency
further
boosted
by
local
hyperthermia
(42.5
°C)
activated
near‐infrared
light.
Through
vitro
vivo
studies,
along
transcriptomic
assessment,
it
confirmed
that
disrupts
feedback
loop
between
inflammation
while
lowering
M1/M2
ratio.
Such
discoveries
contribute
significant
enhancement
healing
process
injuries
undergo
gradual
increase
movement,
covering
wounds
from
back,
mouth,
foot.
Ultimately,
method
provides
easy,
safe,
highly
effective
solution
treating
DFUs.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Окт. 25, 2023
Psoriasis
is
a
common
inflammatory
disease
of
especially
high
recurrence
rate
(90%)
which
suffered
by
approximately
3%
the
world
population.
The
overexpression
reactive
oxygen
species
(ROS)
plays
critical
role
in
psoriasis
progress.
Here
we
show
that
biomimetic
iron
single-atom
catalysts
(FeN4O2-SACs)
with
broad-spectrum
ROS
scavenging
capability
can
be
used
for
treatment
and
relapse
prevention
via
related
gene
restoration.
FeN4O2-SACs
demonstrate
attractive
multiple
enzyme-mimicking
activities
based
on
atomically
dispersed
Fe
active
structures,
are
analogous
to
those
natural
antioxidant
enzymes,
superoxide
dismutase,
human
erythrocyte
catalase,
ascorbate
peroxidase.
Further,
vitro
vivo
experiments
effectively
ameliorate
psoriasis-like
symptoms
prevent
augmented
efficacy
compared
clinical
drug
calcipotriol.
Mechanistically,
estrogen
receptor
1
(ESR1)
identified
as
core
protein
upregulated
through
RNA
sequencing
bioinformatic
analysis.
Together,
this
study
provides
proof
concept
catalytic
therapy
(PCT)
multienzyme-inspired
bionics
(MIB).
Advanced Materials,
Год журнала:
2024,
Номер
36(30)
Опубликована: Май 12, 2024
Zwitterionic
polymers
have
emerged
as
an
important
class
of
biomaterials
to
construct
wound
dressings
and
antifouling
coatings
over
the
past
decade
due
their
excellent
hydrophilicity.
However,
all
reported
zwitterionic
are
nondegradable
because
noncleavable
carbon─carbon
bonding
backbones,
must
be
removed
periodically
after
treatment
avoid
hypoxia
in
wound,
thus
leading
potential
secondary
injury.
In
this
work,
a
biodegradable
polyzwitterion
patch
is
fabricated
for
first
time
by
ring-opening
polymerization
carboxybetaine
dithiolane
(CBDS),
which
self-crosslinked
via
inter-amide
hydrogen
bonds
dipole-dipole
interactions
on
side
chains.
The
unprecedented
polyCBDS
(PCBDS)
demonstrates
enough
ductility
owing
intermolecular
physical
fully
cover
irregular
wounds,
also
showing
biodegradability
performance
resulted
from
existence
disulfide
groups.
Besides,
PCBDS
degradation-induced
released
CBDS
owns
potent
antioxidant
antibacterial
activities.
This
used
diabetic
dressing,
inhibiting
bacterial
adhesion
external
surface,
its
degradation
products
can
exactly
kill
bacteria
scavenge
excessive
reactive
oxygen
species
(ROS)
at
site
regulate
local
microenvironment,
including
regulation
cytokine
express
macrophage
polarization,
accelerating
infected
repair,
avoiding