Intratumoral
microbiota
have
been
identified
as
a
component
of
the
tumor
microenvironment
that
regulates
metastatic
behavior
tumors.
They
serve
not
only
indicators
pathology
but
also
potential
drug
targets
in
cancer
therapy.
Herein,
multifunctional
nanoplatform
(DD@FEL)
is
prepared
by
combining
antibiotic
doxycycline
(DOXY)
can
combat
intratumoral
and
chemotherapeutic
doxorubicin
(DOX)
ergosterol-originated
liposome.
Specially,
ergosterol
utilized
substitute
for
cholesterol
liposomes
to
exert
pharmacological
activity.
Mechanistically,
DD@FEL
leveraged
DOXY
inhibit
metastasis
based
on
regulation
microbiota,
which
synergizes
with
effect
DOX,
eventually
inhibiting
progression
triple-negative
breast
(TNBC).
Verified
both
vitro
vivo,
effectively
exerts
cytotoxic
TNBC
cells,
delays
growth
primary
TNBC,
attenuates
development
its
lung
metastasis,
providing
promising
therapeutic
strategy
control
orthotopic
TNBC.
Immune-mediated
inflammatory
diseases
(IMIDs)
impose
an
immeasurable
burden
on
individuals
and
society.
While
the
conventional
use
of
immunosuppressants
disease-modifying
drugs
has
provided
partial
relief
control,
their
inevitable
side
effects
limited
efficacy
cast
a
shadow
over
finding
cure.
Promising
nucleic
acid
have
shown
potential
to
exert
precise
at
molecular
level,
with
different
classes
acids
having
regulatory
functions
through
varying
mechanisms.
For
better
delivery
acids,
safe
effective
viral
vectors
non-viral
systems
(including
liposomes,
polymers,
etc.)
been
intensively
explored.
Herein,
after
describing
range
categories
vectors,
we
focus
application
therapeutic
in
various
IMIDs,
including
rheumatoid
arthritis,
bowel
disease,
psoriasis,
multiple
sclerosis,
asthma,
ankylosing
spondylitis,
systemic
lupus
erythematosus,
uveitis.
Molecules
implicated
inflammation
immune
dysregulation
are
abnormally
expressed
series
meticulous
modulation
therapy
results
degrees
remission
improvement
these
diseases.
By
synthesizing
findings
centered
specific
targets,
this
review
delivers
systematic
elucidation
perspective
towards
advancing
utilization
therapeutics
for
managing
IMIDs.
As
an
advanced
nucleic
acid
therapeutical
modality,
mRNA
can
express
any
type
of
protein
in
principle
and
thus
holds
great
potential
to
prevent
treat
various
diseases.
Despite
the
success
COVID-19
vaccines,
direct
local
delivery
into
lung
by
inhalation
would
greatly
reinforce
treatment
pulmonary
pathogens
Herein,
we
developed
lipid
nanoparticles
(LNPs)
from
degradable
ionizable
glycerolipids
for
potent
via
nebulization.
A
panel
proprietary
with
branched
tails
five
ester
bonds
were
through
a
three-step
esterification
reaction,
LNPs
formed
lead
glycerolipid
identified
as
TG4C
enabled
highly
efficient
vivo
systemic
administration
around
6-fold
higher
luciferase
expression
than
commercial
SM102
Dlin-MC3-DMA
(MC3).
Formulation
screening
revealed
that
at
TG4C:DOPE:cholesterol:DMG-PEG
molar
ratio
50:10:38.5:1.5
(TG4C-LNPs4)
had
high
stability
against
nebulization
slight
changes
size
distribution
encapsulation
efficiency,
nebulized
TG4C-LNPs4
afforded
equivalent
percentage
positive
cells
slightly
lower
EGFP
fluorescence
intensity
cell
lines
(A549,
BEAS-2B).
Following
mice,
induced
transfection
majority
epithelial
lung,
leading
apparent
bioluminescence
evenly
distributed
all
lobes.
In
elastase-induced
emphysema
model
loaded
encoding
hepatocyte
growth
factor
could
significantly
suppress
secretion
inflammatory
cytokines
(IL-1β,
IL-6,
TNF-α)
bronchoalveolar
lavage
fluid
counteract
alveoli
wall
thinning.
Notably,
partial
substitution
(25%)
cholesterol
budesonide,
anti-inflammatory
glucocorticoid,
generated
improved
therapeutic
efficacy.
Taken
together,
our
study
provides
robust
high-performing
nanovehicles
based
on
glycerolipids,
enabling
potently
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Violet
phosphorus
(VP)
is
a
allotrope
first
discovered
by
Hittorf
in
1865,
which
has
aroused
more
attention
the
biomedical
field
recent
years
attributed
to
its
gradually
unique
properties.
VP
can
be
further
categorized
into
bulk
VP,
nanosheets
(VPNs),
and
quantum
dots
(VPQDs),
chemical
vapor
transport
(CVT),
liquid‐phase/mechanical/laser
exfoliation,
solvothermal
synthesis
are
common
preparation
approaches
of
VPNs,
VPQDs,
respectively.
Compared
with
another
(black
phosphorus,
BP)
that
once
highly
regarded
applications,
nanomaterial
(namely
VPNs
VPQDs)
not
only
exhibits
tunable
bandgap,
moderate
on/off
current
ratio,
good
biodegradability,
but
shows
enhanced
stability
biosafety
as
well,
allowing
it
promising
candidate
for
variety
applications
like
antibacterial
therapy,
anticancer
biosensing
disease
diagnosis.
In
this
review,
classification
relevant
routes
initially
summarized,
properties
momentous
subsequently
expounded.
The
latest
research
advances
emerging
then
introduced
detail,
both
existing
challenges
future
prospects
also
discussed.
Dentistry Journal,
Год журнала:
2025,
Номер
13(2), С. 79 - 79
Опубликована: Фев. 13, 2025
Background:
Recent
advances
in
mRNA
vaccine
technology,
accelerated
by
the
global
COVID-19
pandemic,
have
generated
significant
interest
their
applications
beyond
infectious
diseases.
Dentistry
has
emerged
as
a
promising
field
for
exploring
potential
of
mRNA-based
therapies
preventing
and
treating
oral
Objectives:
This
narrative
review
aims
to
evaluate
current
status
development
its
preclinical
health,
focusing
on
periodontal
disease,
dental
caries,
regenerative
medicine,
implantology,
cancer.
Methods:
The
synthesizes
findings
from
studies,
including
research
conducted
animal
models
vitro,
assess
modulate
immune
responses
promote
tissue
regeneration
cavity.
Clinical
trials
were
only
mentioned
context
broader
areas
implementation
such
oncology
immunotherapy.
Results:
studies
highlight
capacity
vaccines
enhance
body's
response
facilitate
repair
processes.
Despite
these
results,
challenges
persist
delivering
effectively
within
complex
environment.
These
include
stability,
delivery
mechanisms,
modulation
responses.
Conclusions:
While
offer
promise
revolutionizing
health
care,
they
face
notable
limitations
concerning
safety,
efficacy,
clinical
feasibility.
Overcoming
obstacles
through
further
is
essential
unlock
full
translational
ensure
safe
effective
integration
into
practice.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(4)
Опубликована: Июль 1, 2024
Abstract
mRNA
therapeutics
have
shown
great
potential
for
a
broad
spectrum
of
disease
treatment.
However,
the
challenges
mRNA's
inherent
instability
and
difficulty
in
cellular
entry
hindered
its
progress
biomedical
field.
To
address
barriers
deliver
to
cells
interest,
various
delivery
systems
are
designed.
Among
these,
lipid
nanoparticles
(LNPs)
stand
out
as
most
extensively
used
systems,
particularly
following
clinical
approvals
corona
virus
2019
(COVID‐19)
vaccines.
LNPs
comprised
ionizable
cationic
lipids,
phospholipids,
cholesterol,
polyethylene
glycol
derived
lipids
(PEG‐lipids).
In
this
review,
we
primarily
summarize
recent
advancements
LNP
technology,
focusing
on
structures
four
constituents
their
applications.
We
delve
into
structure–activity
relationships
while
also
exploring
future
prospects
developing
more
efficacious
systems.
This
article
is
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Biology‐Inspired
Nanomaterials
Lipid‐Based
Structures
Nanotechnology
Biology
Nanoscale
Systems
Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
4(4)
Опубликована: Янв. 26, 2024
This
review
is
aiming
to
systematically
elucidate
the
unique
role
of
nanotechnology
in
optimizing
therapeutic
modalities
for
combinatorial
cancer
immunotherapy,
which
enables
synergistic
integration
multiple
treatment
strategies.
In
particular,
has
enabled
combination
immunotherapy
with
physical
therapies,
chemotherapy,
metal
therapy,
and
nucleic
acid
therapy.
each
regimen,
nanocarriers
play
multifaceted
roles
by
achieving
targeted
codelivery
different
therapeutics
individual
modality.
offers
new
paradigms
guide
precision
medicine
treatment.
Immunotherapy
alone
unlikely
achieve
personalized
cancer,
are
needed
future.
To
overcome
technical
bottlenecks
realize
precise
regulation
tumor
microenvironment
treatment,
it
crucial
develop
novel
nanosystems
integrated
sensing,
targeting,
functionalities.
Chemical Engineering Journal,
Год журнала:
2024,
Номер
490, С. 151892 - 151892
Опубликована: Май 3, 2024
Cell-based
therapies
are
used
extensively
in
tissue
engineering
because
of
their
great
biosafety
and
diverse
biological
functions.
Among
them,
macrophage
lysate
provides
a
comprehensive
rich
network
cytokines
to
modulate
the
local
immune
microenvironment.
However,
effective
strategies
for
lysate-based
biomaterials
with
immune-regulatory
function
still
lacking.
In
this
study,
we
engineered
silk
fibroin
hydrogel
loaded
THP-1
whole-cell
regulate
microenvironment
promote
vascularized
bone
regeneration
diabetic
defects.
Specifically,
by
modulating
expression
pattern
key
enzyme
energy
metabolism
(mitochondrial
phosphoenolpyruvate
carboxykinase,
PCK2)
cells,
generated
enriched
anti-inflammatory
factors.
This
facilitated
osteogenic
differentiation
BMSCs
angiogenesis
HUVECs
vitro,
incorporating
immunomodulatory
into
enhanced
diabetes.
Mechanistically,
revealed
that
PCK2
activated
nuclear
factor-kappa
B
(NF-κB)
signaling
pathway
macrophages
using
proteomic
profiling.
research
new
insights
design
cell-derived
biomaterials,
aiming
improve
therapeutic
outcomes
pathological
Cancer Drug Resistance,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 21, 2024
The
increasing
prevalence
of
cancer
drug
resistance
not
only
critically
limits
the
efficiency
traditional
therapies
but
also
causes
relapses
or
recurrences
cancer.
Consequently,
there
remains
an
urgent
need
to
address
intricate
landscape
beyond
therapies.
Recently,
nanotechnology
has
played
important
role
in
field
various
delivery
systems
for
treatment
cancer,
especially
therapy-resistant
Among
advanced
nanomedicine
technologies,
lipid-based
nanomaterials
have
emerged
as
effective
carriers
treatment,
significantly
improving
therapeutic
effects.
Due
their
biocompatibility,
simplicity
preparation,
and
potential
functionalization,
are
considered
powerful
competitors
resistant
In
this
review,
overview
addressing
is
discussed.
We
summarize
recent
progress
overcoming
by
these
nanomaterials,
highlight
future
applications
reverse
resistance.
