A Nano-Strategy for Advanced Triple-Negative Breast Cancer Therapy by Regulating Intratumoral Microbiota DOI
Jifan Gao, Lu Tang,

Cong Fu

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Intratumoral microbiota have been identified as a component of the tumor microenvironment that regulates metastatic behavior tumors. They serve not only indicators pathology but also potential drug targets in cancer therapy. Herein, multifunctional nanoplatform (DD@FEL) is prepared by combining antibiotic doxycycline (DOXY) can combat intratumoral and chemotherapeutic doxorubicin (DOX) ergosterol-originated liposome. Specially, ergosterol utilized substitute for cholesterol liposomes to exert pharmacological activity. Mechanistically, DD@FEL leveraged DOXY inhibit metastasis based on regulation microbiota, which synergizes with effect DOX, eventually inhibiting progression triple-negative breast (TNBC). Verified both vitro vivo, effectively exerts cytotoxic TNBC cells, delays growth primary TNBC, attenuates development its lung metastasis, providing promising therapeutic strategy control orthotopic TNBC.

Language: Английский

Clinical advances of mRNA vaccines for cancer immunotherapy DOI Creative Commons
Alexey V. Yaremenko, Muhammad Muzamil Khan,

Xueyan Zhen

et al.

Med, Journal Year: 2025, Volume and Issue: 6(1), P. 100562 - 100562

Published: Jan. 1, 2025

Language: Английский

Citations

4
Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery DOI Creative Commons
Lingxiao Xu, Z. Shao, Xia Fang

et al.

Exploration, Journal Year: 2024, Volume and Issue: unknown

Published: May 24, 2024

Immune-mediated inflammatory diseases (IMIDs) impose an immeasurable burden on individuals and society. While the conventional use of immunosuppressants disease-modifying drugs has provided partial relief control, their inevitable side effects limited efficacy cast a shadow over finding cure. Promising nucleic acid have shown potential to exert precise at molecular level, with different classes acids having regulatory functions through varying mechanisms. For better delivery acids, safe effective viral vectors non-viral systems (including liposomes, polymers, etc.) been intensively explored. Herein, after describing range categories vectors, we focus application therapeutic in various IMIDs, including rheumatoid arthritis, bowel disease, psoriasis, multiple sclerosis, asthma, ankylosing spondylitis, systemic lupus erythematosus, uveitis. Molecules implicated inflammation immune dysregulation are abnormally expressed series meticulous modulation therapy results degrees remission improvement these diseases. By synthesizing findings centered specific targets, this review delivers systematic elucidation perspective towards advancing utilization therapeutics for managing IMIDs.

Language: Английский

Citations

10
Emerging Violet Phosphorus Nanomaterial for Biomedical Applications DOI Open Access
Yijun Mei,

Yuanyuan Cao,

Wei Wang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Violet phosphorus (VP) is a allotrope first discovered by Hittorf in 1865, which has aroused more attention the biomedical field recent years attributed to its gradually unique properties. VP can be further categorized into bulk VP, nanosheets (VPNs), and quantum dots (VPQDs), chemical vapor transport (CVT), liquid‐phase/mechanical/laser exfoliation, solvothermal synthesis are common preparation approaches of VPNs, VPQDs, respectively. Compared with another (black phosphorus, BP) that once highly regarded applications, nanomaterial (namely VPNs VPQDs) not only exhibits tunable bandgap, moderate on/off current ratio, good biodegradability, but shows enhanced stability biosafety as well, allowing it promising candidate for variety applications like antibacterial therapy, anticancer biosensing disease diagnosis. In this review, classification relevant routes initially summarized, properties momentous subsequently expounded. The latest research advances emerging then introduced detail, both existing challenges future prospects also discussed.

Language: Английский

Citations

1
Revolutionizing Dentistry: Preclinical Insights and Future Applications of mRNA Vaccines in Dentistry—A Narrative Review DOI Creative Commons
Luciana Koren,

Andro Koren,

Robert Likić

et al.

Dentistry Journal, Journal Year: 2025, Volume and Issue: 13(2), P. 79 - 79

Published: Feb. 13, 2025

Background: Recent advances in mRNA vaccine technology, accelerated by the global COVID-19 pandemic, have generated significant interest their applications beyond infectious diseases. Dentistry has emerged as a promising field for exploring potential of mRNA-based therapies preventing and treating oral Objectives: This narrative review aims to evaluate current status development its preclinical health, focusing on periodontal disease, dental caries, regenerative medicine, implantology, cancer. Methods: The synthesizes findings from studies, including research conducted animal models vitro, assess modulate immune responses promote tissue regeneration cavity. Clinical trials were only mentioned context broader areas implementation such oncology immunotherapy. Results: studies highlight capacity vaccines enhance body's response facilitate repair processes. Despite these results, challenges persist delivering effectively within complex environment. These include stability, delivery mechanisms, modulation responses. Conclusions: While offer promise revolutionizing health care, they face notable limitations concerning safety, efficacy, clinical feasibility. Overcoming obstacles through further is essential unlock full translational ensure safe effective integration into practice.

Language: Английский

Citations

1
An overview of lipid constituents in lipid nanoparticle mRNA delivery systems DOI

Shiqi Wu,

Lixin Lin, Lu Shi

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(4)

Published: July 1, 2024

Abstract mRNA therapeutics have shown great potential for a broad spectrum of disease treatment. However, the challenges mRNA's inherent instability and difficulty in cellular entry hindered its progress biomedical field. To address barriers deliver to cells interest, various delivery systems are designed. Among these, lipid nanoparticles (LNPs) stand out as most extensively used systems, particularly following clinical approvals corona virus 2019 (COVID‐19) vaccines. LNPs comprised ionizable cationic lipids, phospholipids, cholesterol, polyethylene glycol derived lipids (PEG‐lipids). In this review, we primarily summarize recent advancements LNP technology, focusing on structures four constituents their applications. We delve into structure–activity relationships while also exploring future prospects developing more efficacious systems. This article is categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Biology‐Inspired Nanomaterials Lipid‐Based Structures Nanotechnology Biology Nanoscale Systems

Language: Английский

Citations

8
Nanotechnology‐Empowered Combination Cancer Immunotherapies: Mechanisms, Synergies, and Perspectives DOI Creative Commons
Yuqing Pan, Xiangdong Xue, Xing‐Jie Liang

et al.

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(4)

Published: Jan. 26, 2024

This review is aiming to systematically elucidate the unique role of nanotechnology in optimizing therapeutic modalities for combinatorial cancer immunotherapy, which enables synergistic integration multiple treatment strategies. In particular, has enabled combination immunotherapy with physical therapies, chemotherapy, metal therapy, and nucleic acid therapy. each regimen, nanocarriers play multifaceted roles by achieving targeted codelivery different therapeutics individual modality. offers new paradigms guide precision medicine treatment. Immunotherapy alone unlikely achieve personalized cancer, are needed future. To overcome technical bottlenecks realize precise regulation tumor microenvironment treatment, it crucial develop novel nanosystems integrated sensing, targeting, functionalities.

Language: Английский

Citations

6
Membrane-coated protein nanoparticles for mRNA delivery DOI

Xinxi Cai,

Aftab Ullah,

Rui Qian

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 93, P. 105427 - 105427

Published: Feb. 5, 2024

Language: Английский

Citations

6
Macrophage lysate-derived cytokine network combined with silk fibroin hydrogel promotes diabetic vascularized bone regeneration DOI Creative Commons
Muxin Yue,

Yong-sheng Zhou,

Zheng Li

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151892 - 151892

Published: May 3, 2024

Cell-based therapies are used extensively in tissue engineering because of their great biosafety and diverse biological functions. Among them, macrophage lysate provides a comprehensive rich network cytokines to modulate the local immune microenvironment. However, effective strategies for lysate-based biomaterials with immune-regulatory function still lacking. In this study, we engineered silk fibroin hydrogel loaded THP-1 whole-cell regulate microenvironment promote vascularized bone regeneration diabetic defects. Specifically, by modulating expression pattern key enzyme energy metabolism (mitochondrial phosphoenolpyruvate carboxykinase, PCK2) cells, generated enriched anti-inflammatory factors. This facilitated osteogenic differentiation BMSCs angiogenesis HUVECs vitro, incorporating immunomodulatory into enhanced diabetes. Mechanistically, revealed that PCK2 activated nuclear factor-kappa B (NF-κB) signaling pathway macrophages using proteomic profiling. research new insights design cell-derived biomaterials, aiming improve therapeutic outcomes pathological

Language: Английский

Citations

5
Recent advanced lipid-based nanomedicines for overcoming cancer resistance DOI Open Access

Piroonrat Dechbumroong,

Runjing Hu,

Wisawat Keaswejjareansuk

et al.

Cancer Drug Resistance, Journal Year: 2024, Volume and Issue: unknown

Published: June 21, 2024

The increasing prevalence of cancer drug resistance not only critically limits the efficiency traditional therapies but also causes relapses or recurrences cancer. Consequently, there remains an urgent need to address intricate landscape beyond therapies. Recently, nanotechnology has played important role in field various delivery systems for treatment cancer, especially therapy-resistant Among advanced nanomedicine technologies, lipid-based nanomaterials have emerged as effective carriers treatment, significantly improving therapeutic effects. Due their biocompatibility, simplicity preparation, and potential functionalization, are considered powerful competitors resistant In this review, overview addressing is discussed. We summarize recent progress overcoming by these nanomaterials, highlight future applications reverse resistance.

Language: Английский

Citations

5
Principles of lipid nanoparticle design for mRNA delivery DOI Creative Commons
Yiran Zhang, Xinyue Zhang, Yongsheng Gao

et al.

BMEMat, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Abstract mRNA therapeutics have significantly evolved within the life sciences, particularly in applications such as vaccines, tumor immunotherapy, protein replacement, gene editing, and monoclonal antibody therapy. To fully realize potential of drugs mitigate adverse effects, substantial vector materials been developed for delivery these pharmaceutical agents. Lipid nanoparticles (LNPs) represent most clinically advanced carriers, recognized by U.S. Food Drug Administration approved vaccines numerous clinical trials. Diverse therapeutic necessitate tailored design LNPs. Herein, we outline principles LNP delivery, focusing specifically on their effectiveness, targeting capabilities, safety profiles, nanoparticle stability. Additionally, present latest advancements mRNA‐LNP technology. This review aims to elucidate benefits systems therapeutics, providing insights into breakthroughs innovative ideas further enhancing advantages. These summaries are dedicated promoting broader LNP‐mRNA drugs, aiming advance treatment serious diseases an effective safe manner.

Language: Английский

Citations

5