Asian Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
unknown, С. 101025 - 101025
Опубликована: Фев. 1, 2025
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
has
a
high
global
incidence
and
associated
with
increased
lipid
accumulation
in
hepatocytes,
elevated
hepatic
enzyme
levels,
fibrosis,
carcinoma.
Despite
decades
of
research
significant
advancements,
the
treatment
MASLD
still
faces
formidable
challenges.
Nanoprobes
for
diagnostics
nanomedicine
targeted
drug
delivery
to
present
promising
options
diagnosis
treatment,
enhancing
both
imaging
contrast
bioavailability.
Here,
we
review
recent
advances
nanotechnology
applied
specifically
focusing
on
systems
targeting
stellate
cells,
Kupffer
sinusoidal
endothelial
cells.
This
aims
provide
an
overview
nanomedicine's
potential
early
therapeutic
interventions,
addressing
related
complications.
The
acidic
characteristic
of
the
tumor
site
is
one
most
well-known
features
and
provides
a
series
opportunities
for
cancer-specific
theranostic
strategies.
In
this
regard,
pH-responsive
nanoplatforms
that
integrate
diagnostic
therapeutic
capabilities
are
highly
developed.
fluidity
microenvironment
(TME),
with
its
temporal
spatial
heterogeneities,
makes
noninvasive
molecular
magnetic
resonance
imaging
(MRI)
technology
very
desirable
TME
constituents
developing
MRI-guided
tumor-specific
treatments.
Therefore,
various
MRI-based
strategies
which
employ
assorted
modes
have
been
drawn
up
more
efficient
cancer
therapy
through
raised
local
concentration
agents
in
pathological
tissues.
review,
we
summarize
mechanisms
organic
components
(including
polymers,
biological
molecules,
organosilicas)
as
well
inorganic
metal
coordination
compounds,
oxides,
salts)
nanoplatforms.
Furthermore,
review
designs
applications
diagnosis
treatment
cancer.
addition,
challenges
prospects
pH-responsiveness
discussed.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(10)
Опубликована: Янв. 10, 2024
Giant
heterometallic
polyoxometalate
(POM)
clusters
with
precise
atom
structures,
flexibly
adjustable
and
abundant
active
sites
are
promising
for
constructing
functional
nanodrugs.
However,
current
POM
drugs
almost
vacant
in
orthotopic
brain
tumor
therapy
due
to
the
inability
effectively
penetrate
blood-brain
barrier
(BBB)
low
drug
activity.
Here,
we
designed
largest
(3.0
nm
×
6.0
nm)
transition-metal-lanthanide
co-encapsulated
cluster
{[Ce
ACS Nano,
Год журнала:
2024,
Номер
18(12), С. 9100 - 9113
Опубликована: Март 13, 2024
Reactive
oxygen
species
(ROS)
mediated
tumor
cell
death
is
a
powerful
anticancer
strategy.
Cuproptosis
copper-dependent
and
ROS-mediated
prospective
therapy
However,
the
complex
microenvironment
(TME),
low
specificity,
poor
efficiency,
lack
of
imaging
capability
impair
output
current
cuproptosis
drugs.
Herein,
we
designed
dual-responsive
two-dimensional
metal–organic
framework
(2D
MOF)
nanotheranostic
via
coordination
self-assembly
strategy
using
Au(III)
tetra-(4-pyridyl)
porphine
(AuTPyP)
as
ligand
copper
ions
(Cu2+)
nodes.
The
dual-stimulus
combined
with
protonation
pyridyl
group
in
AuTPyP
deep-penetration
ultrasound
(US)
together
triggered
controlled
release
an
acidic
TME.
ultrathin
structure
(3.0
nm)
nanotheranostics
promoted
process.
released
Cu2+
was
reduced
to
Cu+
by
depleting
overexpressed
glutathione
(GSH)
tumor,
which
not
only
activated
Ferredoxin
1
(FDX1)-mediated
but
also
catalyzed
hydrogen
peroxide
(H2O2)
into
reactive
Fenton-like
reaction.
Simultaneously,
could
specifically
bind
thioredoxin
reductase
activate
redox
imbalance
cells.
These
selectively
induced
significant
mitochondrial
vacuoles
prominent
did
damage
normal
fluorescence
magnetic
resonance
(MRI)
results
verified
this
target
HeLa
greatly
promote
self-enhanced
effect
chemotherapy/cuproptosis
inhibition
efficiency.
work
helped
elucidate
assembly
multiresponsive
high-specificity
ROS
regulation
for
application
therapy.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 705 - 721
Опубликована: Янв. 1, 2025
The
metabolic
activity
of
tumor
cells
leads
to
the
acidification
surrounding
microenvironment,
which
provides
new
strategies
for
application
nanotechnology
in
cancer
therapy.Researchers
have
developed
various
types
pH-responsive
nanomaterials
based
on
acidic
microenvironment.This
review
an
in-depth
discussion
design
mechanisms,
drug-loading
strategies,
and
pathways
microenvironment-responsive
nanodrug
delivery
systems.These
materials
trigger
drug
release
upon
reaching
enhancing
therapeutic
targeting
reducing
toxicity
healthy
cells.pH-responsive
include
organic
nanomaterials,
inorganic
composite
nanomaterials.Additionally,
this
outlines
prospects,
challenges
aiming
promote
development
clinical
translation
field.
Advanced Materials,
Год журнала:
2023,
Номер
35(38)
Опубликована: Июнь 8, 2023
Abstract
Cancer
stem‐like
cells
(CSCs),
capable
of
indefinite
self‐renewal
and
differentiation,
are
considered
to
be
the
root
cause
tumor
radiotherapy
(RT)
resistance.
However,
CSCs‐targeted
therapy
still
remains
a
great
challenge
because
they
commonly
located
in
deep
making
drugs
hard
approach,
their
hypoxic
acidic
niche
can
further
aggravate
radioresistance.
Herein,
based
on
finding
that
CSCs
highly
express
carbonic
anhydrase
IX
(CAIX)
cell
membrane,
CAIX‐targeted
induced
situ
self‐assembly
system
surface
CSC
is
reported
overcome
CSC‐mediated
Via
sequential
processes
“monomer
release‐target
accumulation‐surface
self‐assembly”,
constructed
peptide‐based
drug
delivery
(CA‐Pt)
exhibits
advantages
penetration,
amplified
CAIX
inhibition,
enhanced
cellular
uptake,
which
greatly
relieves
microenvironment
promote
differentiation
combines
with
platinum
boost
RT‐inducing
DNA
damage.
In
both
lung
cancer
mouse
zebrafish
embryo
models,
CA‐Pt
treatment
effectively
assist
RT
suppressing
growth
preventing
invasion
metastasis.
This
study
uses
surface‐induced
strategy
differentiate
CSCs,
may
provide
universal
for
overcoming
Although
the
extraordinary
progress
has
been
made
in
molecular
biology,
prevention
of
cancer
remains
arduous.
Most
solid
tumours
exhibit
both
spatial
and
temporal
heterogeneity,
which
is
difficult
to
be
mimicked
vitro.
Additionally,
complex
biochemical
immune
features
tumour
microenvironment
significantly
affect
development.
Molecular
imaging
aims
at
exploitation
tumour-associated
molecules
as
specific
targets
customized
probe,
thereby
generating
image
contrast
markers,
offering
opportunities
non-invasively
evaluate
pathological
characteristics
vivo.
Particularly,
there
are
no
"standard
markers"
control
clinical
diagnosis
individuals,
so
characteristics-responsive
nanoprobe-based
quantitative
imaging,
able
visualize
determine
accurate
content
values
heterogeneous
distribution
tumours,
can
provide
criteria
for
diagnosis.
In
this
context,
a
variety
"smart"
nanoprobes
have
designed,
order
feasible
approaches
quantitatively
This
review
summarizes
recent
achievements
designs
these
nanoprobes,
highlights
state-of-the-art
technologies
molecules.
Biomaterials Science,
Год журнала:
2024,
Номер
12(5), С. 1079 - 1114
Опубликована: Янв. 1, 2024
Hydrogels,
formed
from
crosslinked
hydrophilic
macromolecules,
provide
a
three-dimensional
microenvironment
that
mimics
the
extracellular
matrix.
They
served
as
scaffold
materials
in
regenerative
medicine
with
an
ever-growing
demand.
However,
hydrogels
composed
of
only
organic
components
may
not
fully
meet
performance
and
functionalization
requirements
for
various
tissue
defects.
Composite
hydrogels,
containing
inorganic
components,
have
attracted
tremendous
attention
due
to
their
unique
compositions
properties.
Rigid
particles,
rods,
fibers,
