Molecules,
Год журнала:
2024,
Номер
29(19), С. 4584 - 4584
Опубликована: Сен. 26, 2024
The
proposed
paper
describes
a
simple
and
environmentally
friendly
method
for
the
synthesis
of
three-component
polymer–inorganic
composites,
which
includes
modification
zinc
oxide
or
montmorillonite
(MMT)
with
chitosan
(CS),
followed
by
immobilization
palladium
on
resulting
two-component
composites.
structures
properties
obtained
composites
were
characterized
physicochemical
methods
(IRS,
TEM,
XPS,
SEM,
EDX,
XRD,
BET).
Pd–CS
species
covered
surface
inorganic
materials
through
two
different
mechanisms.
interaction
polyelectrolyte
led
to
deprotonation
its
amino
groups
deposition
ZnO.
Pd
CS/ZnO
occurred
hydrolysis
[PdCl4]2−,
forming
PdO
particles
interacting
chitosan.
In
case
CS/MMT,
protonated
CS
interacted
negative
sites
MMT,
positively
charged
CS/MMT
composite.
Furthermore,
[PdCl4]2−
–NH3+
electrostatic
force.
According
TEM
studies
1%Pd–CS/ZnO,
presence
nanoclusters
composed
smaller
nanoparticles
3–4
nm
in
size
observed
CS/ZnO.
For
1%Pd–CS/MMT,
sizes
2
evenly
distributed
support
surface.
prepared
CS–inorganic
tested
hydrogenation
2-propen-1-ol
acetylene
compounds
(phenylacetylene,
2-hexyn-1-ol)
under
mild
conditions
(T—40
°C,
PH2—1
atm).
It
was
shown
that
efficiency
1%Pd–CS/MMT
is
higher
than
can
be
explained
formation
are
mechanism
2-hexyn-1-ol
over
an
optimal
catalyst
proposed.
Abstract
Surgical
resection
remains
the
mainstream
treatment
for
malignant
melanoma.
However,
challenges
in
wound
healing
and
residual
tumor
metastasis
pose
significant
hurdles,
resulting
high
recurrence
rates
patients.
Herein,
a
bioactive
injectable
hydrogel
(BG‐Mn
gel
)
formed
by
crosslinking
sodium
alginate
(SA)
with
manganese‐doped
glass
(BG‐Mn)
is
developed
as
versatile
platform
anti‐tumor
immunotherapy
postoperative
The
incorporation
of
Mn
2+
within
(BG)
can
activate
cGAS‐STING
immune
pathway
to
elicit
robust
response
cancer
immunotherapy.
Furthermore,
doping
BG
endows
system
excellent
photothermal
properties,
hence
facilitating
STING
activation
reversing
immune‐suppressive
microenvironment.
exhibits
favorable
angiogenic
capacity
tissue
regenerative
potential,
promotes
cell
migration
vitro.
When
combining
BG‐Mn
anti‐PD‐1
antibody
(α‐PD‐1)
melanoma,
it
shows
enhanced
long‐term
memory
response.
Remarkably,
upregulate
expression
genes
related
blood
vessel
formation
promote
skin
regeneration
when
treating
full‐thickness
wounds.
Overall,
Gel
serves
an
effective
adjuvant
therapy
regulate
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(34)
Опубликована: Март 10, 2024
Abstract
Native
bone
inherently
requires
a
balanced
ionic
microenvironment
to
maintain
homeostasis.
Hence,
scaffolds
designed
for
the
sustained
release
of
therapeutic
ions
into
defects
hold
great
promise
regeneration.
Magnesium
(Mg)
and
silicon
(Si)
are
essential
elements,
which
play
crucial
roles
in
process
regeneration,
impacting
immunomodulation,
angiogenesis,
osteogenesis.
Herein,
porous
cryogel‐type
organic–inorganic
composite
microspheres
developed
as
injectable
microscaffolds
(denoted
GMN).
GMN
enables
Mg/Si
at
an
optimized
ratio,
achieving
most
significant
synergistic
effect
on
vascularized
Various
conditioned
media
obtained
explore
angiogenesis‐osteogenesis
coupling,
well
crosstalk
between
marrow
mesenchymal
stromal
cells
(BMSCs)
macrophages.
Meanwhile,
autocrine
paracrine
effects
simultaneously
modulating
functions
determining
cell
fates
under
guidance
biofactors
secreted
by
cells.
Overall,
ion‐engineering
create
conducive
efficiently
augment
regeneration
tissue
vivo,
offering
versatile
platform
engineering.
Advanced Materials,
Год журнала:
2024,
Номер
36(45)
Опубликована: Сен. 13, 2024
Abstract
Osteochondral
injury
is
a
prevalent
condition
for
which
no
specific
treatment
currently
available.
This
study
presents
piezoelectric‐conductive
scaffold
composed
of
piezoelectric
cartilage‐decellularized
extracellular
matrix
(dECM)
and
modified
gelatin
(Gel‐PC).
The
piezoelectricity
the
achieved
through
modification
diphenylalanine
(FF)
assembly
on
pore
surface,
while
conductive
properties
are
by
incorporating
poly(3,4‐ethylenedioxythiophene).
In
vitro
experiments
demonstrate
that
bone
marrow
mesenchymal
stem
cells
(BMSCs)
undergo
biphasic
division
during
differentiation.
vivo
studies
using
Parma
pig
model
osteochondral
defects
exhibits
superior
reparative
efficacy.
Notably,
generation
electrical
stimulation
linked
to
joint
movement.
During
activity,
mechanical
forces
compress
scaffold,
leading
deformation
subsequent
an
electric
potential
difference.
positive
charges
accumulated
upper
layer
attract
BMSCs,
promoting
their
migration
chondrogenic
Meanwhile,
negative
in
lower
induce
osteogenic
differentiation
BMSCs.
Overall,
this
piezoelectric‐conducive
provides
promising
platform
effective
repair
defects.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Май 28, 2024
The
repair
of
irregular
bone
tissue
suffers
severe
clinical
problems
due
to
the
scarcity
an
appropriate
therapeutic
carrier
that
can
match
dynamic
and
complex
damage.
Fortunately,
stimuli-responsive
in
situ
hydrogel
systems
are
triggered
by
a
special
microenvironment
could
be
ideal
method
regenerating
because
injectability,
gelatin,
spatiotemporally
tunable
drug
release.
Herein,
we
introduce
two
main
stimulus-response
approaches,
exogenous
endogenous,
forming
hydrogels
engineering.
First,
summarize
specific
distinct
responses
extensive
range
external
stimuli
(e.g.,
ultraviolet,
near-infrared,
ultrasound,
etc.)
form
created
from
biocompatible
materials
modified
various
functional
groups
or
hybrid
nanoparticles.
Furthermore,
“smart”
hydrogels,
which
respond
endogenous
physiological
environmental
temperature,
pH,
enzyme,
etc.),
achieve
gelation
one
injection
vivo
without
additional
intervention.
Moreover,
mild
chemistry
response-mediated
also
offer
fascinating
prospects
engineering,
such
as
Diels–Alder,
Michael
addition,
thiol-Michael
Schiff
reactions,
etc.
recent
developments
challenges
smart
their
application
administration
engineering
discussed
this
review.
It
is
anticipated
advanced
strategies
innovative
ideas
will
exploited
field
increase
quality
life
for
patients
with
Advances in medical technologies and clinical practice book series,
Год журнала:
2024,
Номер
unknown, С. 300 - 319
Опубликована: Май 28, 2024
This
chapter
explores
the
use
of
smart
materials
in
physiotherapy,
highlighting
their
potential
to
revolutionize
patient
care
and
rehabilitation
practices.
It
discusses
various
types
materials,
such
as
shape
memory
alloys,
electroactive
polymers,
piezoelectric
magnetorheological
thermoresponsive
unique
properties
applications.
The
also
assistive
devices,
wearable
technology,
rehabilitation,
pain
management,
tissue
healing.
advantages
include
personalization,
real-time
monitoring
capabilities,
non-invasive
nature.
However,
challenges
cost,
integration
with
existing
healthcare
systems,
durability
concerns
need
be
addressed.
concludes
by
exploring
future
advancements
integrating
them
other
technologies
like
AI,
robotics,
nanotechnology.
Ethical
considerations
acceptance
are
emphasized
ensure
responsible
patient-centric
adoption.
Journal of Nanotechnology,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
This
study
presents
the
electrophoretic
deposition
(EPD)
of
hydroxyapatite
(HAP),
chitosan
(CS),
magnesium
oxide
(MgO)
and
silane
coupling
agent
(KH‐550)
coatings
on
316L
stainless
steel
substrates
to
improve
their
corrosion
protective
properties
for
intended
biomedical
applications.
In
addition,
this
work
differentiates
itself
by
analyzing
effects
varying
anodization
times
(5,
10,
15
min)
surface
characteristics,
with
a
particular
focus
roughness,
zeta
potential
suspension,
coating
thickness.
The
results
show
that
root‐mean‐square
roughness
(Sq)
arithmetic
mean
(Sa)
escalated
from
78.18
nm
67.14
uncoated
base
metal
421.7
364.7
nm,
respectively,
after
min
anodization.
Stable
suspension
was
indicated
−39.8
mV.
As
time
increased,
thickness
reached
14.14
μm
min.
atomic
force
microscopy
(AFM)
analysis
used
assess
adhesion
bond
strengths
HAP–CS–MgO
composites
coated
at
different
surface.
composite
10
exhibited
most
substantial
−0.5271
nN,
indicating
highest
reliability
stability
in
bonding
interactions.
KH‐550
concentration
0.0793
g/mL
demonstrated
lowest
rate
0.02933
mm/year,
superior
resistance,
along
−1.0
nN
117.5
μm.
