Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 14, 2024
Abstract
Tirapazamine
(TPZ),
an
antitumor
prodrug,
can
be
activated
in
hypoxic
environment.
It
specifically
targets
the
microenvironment
of
tumors
and
produces
toxic
free
radicals.
However,
due
to
tumor
is
not
completely
hypoxic,
TPZ
often
fails
effectively
treat
entire
tissue,
resulting
suboptimal
therapeutic
outcomes.
Herein,
a
low
pathogenic
Escherichia
coli
TOP10
utilized
selectively
colonize
tissues,
disrupt
blood
vessels,
induce
thrombus
formation,
leading
expansion
region
improving
effect
TPZ.
Additionally,
thermosensitive
hydrogel
constructed
by
Pluronic
F‐127
(F127),
which
undergoes
gelation
situ
at
site,
sustained
release
To
monitor
process,
it
genetically
modified
integrating
bioluminescent
system
luxCDABE
(TOP10‐Lux).
The
signal
associated
with
hypoxia
enhancement
beneficial
for
monitoring
bioluminescence
imaging.
In
murine
colon
cancer
model,
TOP10‐Lux
combined
TPZ‐loaded
F127
suppressed
growth,
treatment
process
efficiently
monitored.
Together,
this
work
employs
enhance
efficacy
providing
effective
strategy
bacteria‐based
tumor‐targeted
chemotherapy
monitoring.
Advanced Materials,
Год журнала:
2024,
Номер
36(30)
Опубликована: Май 1, 2024
Abstract
The
in
vivo
fate
of
chemotherapeutic
drugs
plays
a
vital
role
understanding
the
therapeutic
outcome,
side
effects,
and
mechanism.
However,
lack
imaging
abilities
drugs,
tedious
labeling
processes,
premature
leakage
agents
result
loss
fidelity
between
signals.
Herein,
an
amphiphilic
polymer
is
created
by
copolymerization
near‐infrared‐II
(NIR‐II)
fluorophore
tracer
(T)
anticancer
Pt(IV)
prodrug
(D)
cisplatin
hand‐holding
manner
into
one
chain
for
first
time.
obtained
Polyplatin
DT
capable
delivering
fluorophores
concomitantly
at
precise
D/T
ratio,
thereby
resulting
tracking
platinum
even
readout
them
real‐time
via
NIR‐II
imaging.
can
self‐assemble
nanoparticles,
referred
to
as
Nanoplatin
.
Furthermore,
caspase‐3
cleavable
peptide
that
serves
apoptosis
reporter
attached
,
DTR
are
simultaneously
evaluating
efficacy.
Overall,
it
reported
here
design
theranostic
with
drug
tracers,
efficacy
reporters
work
concert
provide
insight
mechanism
action.
ACS Nano,
Год журнала:
2024,
Номер
18(35), С. 23827 - 23841
Опубликована: Авг. 20, 2024
Carrier-free
nanodrugs
with
extraordinary
active
pharmaceutical
ingredient
(API)
loading
(even
100%),
avoidable
carrier-induced
toxicity,
and
simple
synthetic
procedures
are
considered
as
one
of
the
most
promising
candidates
for
disease
theranostics.
Substantial
studies
commercial
success
"carrier-free"
nanocrystals
have
demonstrated
their
strong
clinical
potential.
However,
practical
translations
remain
challenging
impeded
by
unpredictable
assembly
processes,
insufficient
delivery
efficiency,
an
unclear
in
vivo
fate.
In
this
Perspective,
we
systematically
outline
contemporary
emerging
carrier-free
based
on
diverse
APIs,
well
highlight
opportunities
challenges
translation.
Looking
ahead,
further
improvements
design
preparation,
drug
delivery,
efficacy,
safety
nanomedicines
essential
to
facilitate
translation
from
bench
bedside.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 1, 2024
Abstract
The
heavy
dependence
on
intratumoral
O
2
and
H
availability
has
greatly
restricted
ROS‐based
therapy.
Although
/H
‐irrelevant
free‐radical
nanogenerator
garnered
tremendous
attention
as
a
promising
anticancer
candidate
to
overcome
the
above
intrinsic
limitations
of
treatment,
practical
therapeutic
efficacy
therapy
is
still
hindered
by
limited
type
inferior
tumor
retention
performance.
Herein,
inspired
new
concept
full‐API
nanodrug
(FAND)
with
100%
active
pharmaceutical
ingredient
(API)
content
repurposing
clinical
anti‐malaria
drug
artesunate
(ARTE)
an
generator,
AFeI
FANDs
composed
ARTE,
human
essential
Fe
3+
,
FDA‐approved
fluorescent
agent
ICG
for
hypoxic
are
rationally
designed
constructed.
Attractively,
completely
pharmaceutically
components
can
be
responsively
liberated
in
acidic
microenvironment
synergistically
produce
five
types
free
radicals
including
•O
−
•C,
•OH,
LOO•,
1
leading
robust
mitochondrial
injury,
nuclear
DNA
damage,
lipid
peroxides.
More
importantly,
displayed
ultralong
longer
than
108
h
favorable
suppression
outcomes
under
mild
NIR
irradiation.
Collectively,
presented
first
paradigm
FAND‐based
quintuple
expands
horizons
development
clinically
transferable
nanomedicine
