Biomaterials, Год журнала: 2024, Номер 316, С. 123006 - 123006
Опубликована: Дек. 11, 2024
Язык: Английский
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 17, 2024
Abstract Nanotheranostics, which integrate diagnostic and therapeutic functionalities, offer significant potential for tumor treatment. However, current nanotheranostic systems typically involve multiple molecules, each providing a singular or function, leading to challenges such as complex structural composition, poor targeting efficiency, lack of spatiotemporal control, dependence on single modality. This study introduces NP RBOXA , nanoparticle functionalized with surface‐bound cRGD targeted delivery α v β 3 /α 5 receptors cells, achieving theranostic integration by sequentially switching its irradiation modes. Under 808 nm laser irradiation, emits NIR‐II fluorescence, aids in identifying the nanoparticle's location fluorescence intensity, thereby determining optimal treatment window. Following this, mode switches ultrasound at Ultrasound induces generate reactive oxygen species, promoting reduction OXA‐IV OXA‐II, turn triggers immunogenic cell death. mechanism enables combination sonodynamic therapy, chemotherapy, immunotherapy The versatile design holds promise advancing precision oncology through enhanced efficacy real‐time imaging guidance.
Язык: Английский
Процитировано
8
Biomaterials, Год журнала: 2025, Номер 319, С. 123178 - 123178
Опубликована: Фев. 8, 2025
Язык: Английский
Процитировано
1
RSC Advances, Год журнала: 2024, Номер 14(27), С. 18871 - 18878
Опубликована: Янв. 1, 2024
Synthesis of SeTe–Ag NPs with excellent photothermal and photodynamic properties for bacterial infection wound healing therapy.
Язык: Английский
Процитировано
5
Communications Chemistry, Год журнала: 2024, Номер 7(1)
Опубликована: Июнь 8, 2024
Abstract Nanoparticle-based therapies are emerging as a pivotal frontier in biomedical research, showing their potential combating infections and facilitating wound recovery. Herein, selenium-tellurium dopped copper oxide nanoparticles (SeTe-CuO NPs) with dual photodynamic photothermal properties were synthesized, presenting an efficient strategy for bacterial infections. In vitro evaluations revealed robust antibacterial activity of SeTe-CuO NPs, achieving up to 99% eradication bacteria significant biofilm inhibition upon near-infrared (NIR) irradiation. Moreover, vivo studies demonstrated accelerated closure treatment NIR-activated demonstrating efficacy promoting healing. Furthermore, NPs exhibited rapid clearance within wounds, offering promising solution care. Overall, this versatile platform holds great promise multidrug-resistant advancing therapeutic interventions management.
Язык: Английский
Процитировано
4
Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 19
Опубликована: Март 10, 2025
Cancer remains a significant global health challenge, driving the search for innovative treatments. Photothermal therapy (PTT) has emerged as promising approach, using photothermal agents to convert near-infrared (NIR) light into heat tumor ablation. Among these agents, nano-molybdenum oxide, particularly non-stoichiometric MoO3-x (0 < x 1), stands out due its unique defect structure, strong NIR absorption, high conversion efficiency (PCE), and pH-responsive degradation. This review summarized recent advancements in oxide PTT, covering classification, synthesis, surface modification, tumor-targeting mechanisms. Subsequently, we explored applications PTT combination therapies, evaluated biocompatibility toxicity, discussed current achievements, challenges, future perspectives cancer treatment.
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
Abstract Oxaliplatin (OXA), a third‐generation platinum‐based chemotherapeutic agent, is widely utilized in cancer treatment due to its potent cytotoxic effects and ability induce immunogenic cell death (ICD). However, the clinical application of OXA significantly hindered by inefficient drug delivery. To address these challenges, cascade delivery system that integrates ultrasound (US) activation with Poly‐Oxaliplatin nanoparticles (OXA‐Ce6 NP) developed enhance therapeutic efficacy overcome resistance mechanisms OXA. This sono‐responsive platform consists an amphiphilic polymer incorporating OXA(IV) prodrug (Poly‐OXA(IV)) sonosensitizer chlorin e6 (Ce6), enabling US‐triggered cascade. Upon US exposure, this facilitates 1) enhanced cellular uptake via increased membrane permeability, 2) situ through electron transfer, 3) augmented formation OXA‐DNA adducts, thereby intensifying DNA damage effects. Moreover, US‐induced reactive oxygen species (ROS) further potentiate ICD, remodeling tumor immune microenvironment promoting systemic antitumor immunity. By leveraging as external stimulus, enhances outcome while mitigating toxicity. strategy provides versatile approach optimizing chemotherapy integrating immunotherapy, offering promising avenue for improving treatments.
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 25, 2024
The rapid development of self-assembly technology during the past few decades has effectively addressed plenty issues associated with carrier-based drug delivery systems, such as low loading efficiency, complex fabrication processes, and inherent toxicity carriers. integration nanoscale systems techniques enabled efficient targeted self-administration drugs, enhanced bioavailability, prolonged circulation time, controllable release. Concurrently, limitations single-mode cancer treatment, including poor therapeutic outcomes, significant side effects, have highlighted urgent need for multimodal combined antitumor therapies. Set against backdrop therapy, this review summarizes research progress applications a large number self-assembled platforms, natural small molecule self-assembled, carrier-free amphiphilic polymer-based peptide-based metal-based nano systems. This particularly analyzes latest advances in application platforms therapies mediated by chemotherapy, phototherapy, radiotherapy, sonodynamic immunotherapy, providing innovative insights further optimization expansion clinical translation therapy.
Язык: Английский
Процитировано
0
Biomaterials, Год журнала: 2024, Номер 316, С. 123006 - 123006
Опубликована: Дек. 11, 2024
Язык: Английский
Процитировано
0