Biosensors,
Год журнала:
2024,
Номер
14(8), С. 372 - 372
Опубликована: Июль 31, 2024
The
incidence
of
thyroid
cancer
is
increasing
worldwide.
Fine-needle
aspiration
(FNA)
cytology
widely
applied
with
the
use
extracted
biological
cell
samples,
but
current
FNA
labor-intensive,
time-consuming,
and
can
lead
to
risk
false-negative
results.
Surface-enhanced
Raman
spectroscopy
(SERS)
combined
machine
learning
algorithms
holds
promise
for
diagnosis.
In
this
study,
we
develop
a
label-free
SERS
liquid
biopsy
method
rapid
accurate
diagnosis
by
using
washout
fluids.
These
supernatants
are
mixed
silver
nanoparticle
colloids,
dispersed
in
quartz
capillary
measurements
discriminate
between
healthy
malignant
samples.
We
collect
spectra
36
samples
(18
18
benign)
compare
four
classification
models:
Principal
Component
Analysis-Linear
Discriminant
Analysis
(PCA-LDA),
Random
Forest
(RF),
Support
Vector
Machine
(SVM),
Convolutional
Neural
Network
(CNN).
results
show
that
CNN
algorithm
most
precise,
high
accuracy
88.1%,
sensitivity
87.8%,
area
under
receiver
operating
characteristic
curve
0.953.
Our
approach
simple,
convenient,
cost-effective.
This
study
indicates
assisted
deep
models
great
early
detection
screening
cancer.
The
methodological
advancements
in
surface-enhanced
Raman
scattering
(SERS)
technique
with
nanoscale
materials
based
on
noble
metals,
Au,
Ag,
and
their
bimetallic
alloy
Au-Ag,
has
enabled
the
highly
efficient
sensing
of
chemical
biological
molecules
at
very
low
concentration
values.
By
employing
innovative
various
type
Ag
nanoparticles
especially,
high
efficiency
Au@Ag
nanomaterials
as
substrate
SERS
biosensors
have
revolutionized
detection
components
including;
proteins,
antigens
antibodies
complex,
circulating
tumor
cells,
DNA,
RNA
(miRNA),
etc.
This
review
is
about
SERS-based
Au/Ag
enhanced
activity
by
focusing
different
factors
related
to
them.
emphasis
this
research
describe
recent
developments
field
conceptual
behind
Furthermore,
article
we
apex
understanding
impact
variation
basic
features
like
effects
size,
shape
varying
lengths,
thickness
core-shell
influence
large-scale
magnitude
morphology.
Moreover,
detailed
information
applications
these
importantly
receptor
binding
domain
(RBD)
protein
COVID-19
provided.
Abstract
Nanozymes
show
great
promise
in
enhancing
disease
biomarker
sensing
by
leveraging
their
physicochemical
properties
and
enzymatic
activities.
These
qualities
facilitate
signal
amplification
matrix
effects
reduction,
thus
boosting
performance.
In
this
review,
recent
studies
from
the
last
five
years,
concentrating
on
detection
improvement
through
nanozyme‐based
biosensing
are
examined.
This
enhancement
primarily
involves
modulations
of
size,
morphology,
doping,
modification,
electromagnetic
mechanisms,
electron
conduction
efficiency,
surface
plasmon
resonance
nanozymes
for
increased
sensitivity.
addition,
a
comprehensive
description
synthesis
tuning
strategies
employed
has
been
provided.
includes
detailed
elucidation
catalytic
mechanisms
alignment
with
fundamental
principles
enhanced
technology,
accompanied
presentation
quantitatively
analyzed
results.
Moreover,
diverse
applications
strip
sensing,
colorimetric
electrochemical
surface‐enhanced
Raman
scattering
have
outlined.
Additionally,
limitations,
challenges,
corresponding
recommendations
concerning
application
summarized.
Furthermore,
insights
offered
into
future
development
outlook
biosensing.
review
aims
to
serve
not
only
as
reference
sensitivity
biosensors
but
also
catalyst
exploring
nanozyme
broader
Trends in Food Science & Technology,
Год журнала:
2024,
Номер
145, С. 104350 - 104350
Опубликована: Янв. 24, 2024
The
increasing
incidence
of
fraud
demands
for
new
robust
methods
to
assess
food
authenticity.
Over
the
past
decades,
biosensors
have
emerged
as
practical
testing
devices
with
exponential
growth
in
diverse
research
fields.
Their
numerous
advantages
contributed
their
implementation
sector,
applications
ranging
from
identification
pathogens,
chemical
compounds
and
allergens
spoilage
detection
Genetically
Modified
Organisms
(GMO)
various
products.
This
review
explores
development
DNA-based
authenticity
assessment
a
focus
on
species
identification.
role
versatility
nucleic
acids
analytes
biorecognition
elements
are
discussed,
available
conventional
presented.
main
transducing
principles
involved
biosensing,
use
nanomaterials
briefly
introduced.
application
over
last
decade
is
shown,
highlighting
innovations
how
these
improvement
performance.
final
section
addresses
different
technologies
can
influence
biosensor
manufacturing
optimization,
so
become
established
rapid
on-site
used
In
little
has
been
carried
out
regarding
biosensors.
mainly
aimed
at
meat
derived
products,
although
other
equally
relevant
products
should
be
targeted.
Several
recent
technological
advances
successfully
integrated
into
must
further
explored
promote
establishment
assessment.
Analytica Chimica Acta,
Год журнала:
2024,
Номер
1307, С. 342626 - 342626
Опубликована: Апрель 22, 2024
C-reactive
protein
(CRP)
represents
an
early
clinical
biomarker
that
indicates
the
presence
of
inflammatory
or
infectious
conditions
in
human
body.
Today's
procedures
approved
by
Food
and
Drug
Administration
(FDA)
imply
expensive
equipment
highly
trained
personnel
to
perform
test.
Therefore,
a
new
diagnostic
method
with
high
detection
efficiency
less
cost
is
urgently
needed
for
delivering
rapid
timely
results
point-of-care
(POC)
service.
