ACS Nano,
Год журнала:
2024,
Номер
18(19), С. 12049 - 12095
Опубликована: Май 2, 2024
Cancer,
as
one
of
the
leading
causes
death
worldwide,
drives
advancement
cutting-edge
technologies
for
cancer
treatment.
Transition-metal-based
nanozymes
emerge
promising
therapeutic
nanodrugs
that
provide
a
reference
therapy.
In
this
review,
we
present
recent
breakthrough
First,
comprehensively
outline
preparation
strategies
involved
in
creating
transition-metal-based
nanozymes,
including
hydrothermal
method,
solvothermal
chemical
reduction
biomimetic
mineralization
and
sol–gel
method.
Subsequently,
elucidate
catalytic
mechanisms
(catalase
(CAT)-like
activities),
peroxidase
(POD)-like
oxidase
(OXD)-like
activities)
superoxide
dismutase
(SOD)-like
along
with
their
activity
regulation
such
morphology
control,
size
manipulation,
modulation,
composition
adjustment
surface
modification
under
environmental
stimulation.
Furthermore,
elaborate
on
diverse
applications
anticancer
therapies
encompassing
radiotherapy
(RT),
chemodynamic
therapy
(CDT),
photodynamic
(PDT),
photothermal
(PTT),
sonodynamic
(SDT),
immunotherapy,
synergistic
Finally,
challenges
faced
by
are
discussed
alongside
future
research
directions.
The
purpose
review
is
to
offer
scientific
guidance
will
enhance
clinical
based
transition
metals.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(16), С. 6417 - 6425
Опубликована: Апрель 12, 2024
Molecular
imprinting-based
surface-enhanced
Raman
scattering
(MI-SERS)
sensors
have
shown
remarkable
potential
from
an
academic
standpoint.
However,
their
practical
applications,
especially
in
the
detection
of
large-size
protein
(≥10
nm),
face
challenges
due
to
lack
versatile
sensing
strategies
and
nonspecific
fouling
matrix
species.
Herein,
we
propose
a
reporter
inspector
mechanism
(RRIM)
implemented
on
protein-imprinted
polydopamine
(PDA)
layer
coated
SERS
active
substrate.
In
RRIM,
after
recognition,
permeability
PDA
imprinted
cavities
undergoes
changes
that
are
scrutinized
by
molecules.
Target
proteins
can
specifically
bind
fully
occupy
cavities,
whereas
species
cannot.
Then,
molecules
with
suitable
size
introduced
serve
as
both
inspectors
recognition
status
inducers
signal,
which
only
penetrate
through
vacant
nonspecifically
filled
cavities.
Consequently,
signal
exclusively
originate
specific
binding
target
proteins,
while
is
curbed.
The
RRIM
enables
reproducible
quantitation
cyanobacteria-specific
model
phycocyanin,
at
level
down
2.6
×
10
iScience,
Год журнала:
2025,
Номер
28(2), С. 111763 - 111763
Опубликована: Янв. 7, 2025
Recent
years
have
witnessed
tremendous
advances
in
wearable
sensors,
which
play
an
essential
role
personalized
healthcare
for
their
ability
real-time
sensing
and
detection
of
human
health
information.
Nanozymes,
capable
mimicking
the
functions
natural
enzymes
addressing
limitations,
possess
unique
advantages
such
as
structural
stability,
low
cost,
ease
mass
production,
making
them
particularly
beneficial
constructing
recognition
units
biosensors.
In
this
review,
we
aim
to
delineate
latest
advancements
nanozymes
development
biosensors,
focusing
on
key
developments
nanozyme
immobilization
strategies,
technologies,
biomedical
applications.
The
review
also
highlights
current
challenges
future
perspectives.
Ultimately,
it
aims
provide
insights
research
endeavors
rapidly
evolving
area.
Nanozyme-based
colorimetric
sensors
are
promising
approaches
for
environmental
monitoring,
food
safety,
and
medical
diagnostics.
However,
developing
novel
nanozymes
that
exhibit
high
catalytic
activity,
good
dispersion
in
aqueous
solution,
sensitivity,
selectivity,
stability
is
challenging.
In
this
study,
the
first
time,
single-atom
iridium-doped
carbon
dot
(SA
Ir-CDs)
synthesized
via
a
simple
situ
pyrolysis
process.
Doping
dots
with
iridium
form
of
single
atoms
to
achieve
maximum
atomic
utilization
not
only
enhances
peroxidase
(POD)-like
activity
178.81
U
mg-1
but
also
improves
dispersibility
solutions
over
30
days.
Hence,
SA
Ir-CD
platform
developed
mercury
ions
(Hg2+)
detection
exhibited
linear
relationship
from
0.01
10
µm
limit
4.4
nm.
Notably,
changes
color
can
be
observed
through
naked
eye
smartphone,
enabling
convenient
field
onsite
monitoring
without
need
sophisticated
analytical
equipment.
an
approach
fabricating
metal-based
POD-like
developed,
new
effective
easy-to-use
sensor
Hg2+
constructed.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(15)
Опубликована: Фев. 22, 2024
Abstract
Amyloid
beta‐protein
(AβA
β
)
is
a
main
hallmark
of
Alzheimer's
disease
(AD),
and
low
amount
Aβ
protein
accumulation
appears
to
be
potential
marker
for
AD.
Here,
an
electrochemical
DNA
biosensor
based
on
polyamide/polyaniline
carbon
nanotubes
(PA/PANI‐CNTs)
developed
with
the
aim
diagnosing
AD
early
using
simple,
low‐cost,
accessible
method
rapidly
detect
Aβ42
in
human
blood.
Electrospun
PA
nanofibers
served
as
skeleton
successive
situ
deposition
PANI
CNTs,
which
contribute
both
high
conductivity
abundant
binding
sites
aptamers.
After
aptamers
are
immobilized,
this
aptasensor
exhibits
precise
specific
detection
blood
within
only
4
min
extremely
fast
response
rate,
lower
limit,
excellent
linear
range.
These
findings
make
significant
contribution
advancing
development
serum‐based
techniques
Aβ42,
thereby
paving
way
improved
diagnostic
capabilities
field
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 18, 2024
Multiple
enzyme-induced
cascade
catalysis
has
an
indispensable
role
in
the
process
of
complex
life
activities,
and
is
widely
used
to
construct
robust
biosensors
for
analyzing
various
targets.
The
immobilized
multi-enzyme
system
a
novel
biomimetic
strategy
that
immobilizes
enzymes
with
different
functions
stable
carriers
simulate
synergistic
multiple
biological
systems,
which
enables
high
stability
efficiency
enzymatic
catalysis.
Nanozymes,
type
nanomaterial
intrinsic
enzyme-like
characteristics
excellent
stabilities,
are
also
applied
instead
achieving
better
catalytic
performance
reaction
stability.
Due
good
stability,
reusability,
remarkably
efficiency,
multi-enzyme/nanozyme
systems
show
distinct
advantages
promoting
signal
transduction
amplification,
thereby
attracting
vast
research
interest
biosensing
applications.
This
review
focuses
on
progress
recent
years.
construction
approaches,
factors
affecting
applications
sensitive
discussed
detail.
Further,
their
challenges
outlooks
future
study
provided.
