ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown
Опубликована: Дек. 4, 2024
The sensing of phthalate esters (PAEs) is vital for people's health and environmental protection. This study aimed to develop a highly sensitive selective photoelectrochemical (PEC) biosensor PAEs analysis in complex samples. based on CdS nanoparticle/TiO
Язык: Английский
Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(19), С. 2391 - 2400
Опубликована: Май 28, 2024
Comprehensive Summary Interfacing DNA oligonucleotides and aptamers with gold nanoparticles has generated numerous functional hybrid materials for sensing, self‐assembly drug delivery applications. Our lab been working in this area 15 years. In article, the current understanding of adsorption to is summarized, related applications bioconjugation surface described. addition, problems using signaling aptamer binding are discussed. Finally, re‐selection previously reported targets library‐immobilization method reviewed. What most favorite original chemistry developed your research group? My work study biointerface between enabling rapid by lowering pH freezing. How do you get into specific field? Could please share some experiences our readers? PhD training was focused on catalytic detection metal ions, when I used signal reactions catalyzed DNA. When started my independent career University Waterloo 2009, realized that there were many fundamental issues regarding be studied. first teaching assignment a course named ‘Surfaces Interfaces’. By course, learned lot science concepts later research. That starting point me set up own program area. important personality scientific research? Curiosity, careful observation, critical thinking, keep trying. balance family? Research personal life don’t have always conflict. New ideas may spark am relaxed family environment. journals? Journal American Chemical Society , Angewandte Chemie International Edition Nucleic Acids Analytical Chemistry, Langmuir . hobbies? Running; traveling; watching movies.
Язык: Английский
Процитировано
9
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 13, 2024
Nanozymes, characterized by their nanoscale size and enzyme-like catalytic activities, exhibit diverse therapeutic potentials, including anti-oxidative, anti-inflammatory, anti-microbial, anti-angiogenic effects. These properties make them highly valuable in nanomedicine, particularly ocular therapy, bypassing the need for systemic delivery. Nanozymes show significant promise tackling multi-factored diseases, those influenced oxidation inflammation, like dry eye disease, age-related macular degeneration. Their small size, coupled with ease of modification integration into soft materials, facilitates effective penetration barriers, thereby enabling targeted or prolonged therapy within eye. This review is dedicated to exploring diseases that are intricately linked shedding light on role nanozymes managing these conditions. Additionally, recent studies elucidating advanced applications therapeutics, along materials disease management, discussed. Finally, this outlines directions future investigations aimed at bridging gap between nanozyme research clinical applications.
Язык: Английский
Процитировано
6
iScience, Год журнала: 2024, Номер 27(11), С. 111185 - 111185
Опубликована: Окт. 17, 2024
Язык: Английский
Процитировано
6
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 17, 2024
Abstract Despite recent advancements in the development of blood‐brain barrier (BBB)‐crossing nanomaterials for intravenous administration, there have been very few successful cases clinical trials. Ongoing challenges within body impede precise therapeutic effects these from reaching their intended target area. Therefore, a comprehensive analysis entire pathway that BBB‐crossing must traverse‐from bloodstream to brain‐along with an understanding obstacles encountered along way, is essential advancing materials This review begins brief overview structure and function BBB, as well pathways strategies crossing it. Next, it discussed analyzed common sites brain bloodstream. To address challenges, “eight‐step” guideline strategy proposed. By leveraging principles precision medicine, design customization cascade‐targeted can overcome multiple show promise future trials practical applications. Finally, perspective on direction this field offered.
Язык: Английский
Процитировано
4
Talanta, Год журнала: 2024, Номер 283, С. 127071 - 127071
Опубликована: Окт. 23, 2024
Язык: Английский
Процитировано
3
Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Two modified aptamers for quinine were synthesized by a neoacetalization-based post-SELEX method. One of the dimerized upon binding at high concentration.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159980 - 159980
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Nanoscale, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
This review highlights recent stimulus-responsive antimicrobial nanotherapeutics for ocular infections, focusing on their design, progress, and advantages/limitations.
Язык: Английский
Процитировано
0
Journal of Proteome Research, Год журнала: 2025, Номер unknown
Опубликована: Май 13, 2025
Dry eye syndrome (DES) affects millions of people worldwide. However, as the cellular responses corneal epithelium under hyperosmotic stress remain unclear, this study investigated proteomic changes between human epithelial cells (HCECs) cultured with isosmotic and media. Under stress, HCECs increased expressions sodium-coupled neutral amino acid transporter (SNAT2), glutaminase (GLS-1), a few isoforms heat shock protein aldo-keto reductase family 1. The SNAT2 GLS-1 were after 6 h exposure to but not by glutamine deprivation. intracellular levels glutamine, mitochondrial superoxide, membrane potential induced fission in HCECs. Thus, level was elevated stressed via upregulation SNAT2. Glutamine can act an osmolyte regulate osmolarity or be converted glutamate for tricarboxylic cycle oxidative phosphorylation maintain ATP production stress-induced fission. increases are key osmoregulations upon may biomarkers monitoring DES progression.
Язык: Английский
Процитировано
0
Scientific Data, Год журнала: 2025, Номер 12(1)
Опубликована: Май 23, 2025
The corneal epithelium serves as the front barrier against environmental stimuli and pathogens on ocular surface. A comprehensive protein profile of would be crucial for understanding molecular mechanisms that are related to disease. This work demonstrated a library-free data-independent acquisition (DIA) approach across different mass spectrometers proteomic software build dataset human epithelial cells (HCECs). With combinational use technologies multiple spectrometers, including Sciex ZenoTOF 7600 (DIA-SWATH), Bruker TimsTOF Pro2 (DIA-PASEF), ThermoFisher Orbitrap Fusion Lumos (DIA-HRMS1), identification quantification were performed with superior sensitivity resolution. By using DIA approach, this study constructed more diverse unbiased (HCECs), comprising 11,954 groups (1% FDR). represents largest proteome reported date. All raw data deposited ProteomeXchange Consortium via Proteomics Identifications database (PRIDE) identifier accession number PXD059451. Our findings hold potential enhance future pathologies transformative therapeutics.
Язык: Английский
Процитировано
0