Photothermal Nanozyme‐Encapsulating Microneedles for Synergistic Treatment of Infected Wounds

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 8, 2024

Abstract Photothermal therapy (PTT) is widely used in wound healing because it produces heat under near‐infrared irradiation, eliminating bacterial infections. However, excessive production of reactive oxygen species (ROS) occurs during PTT, which causes oxidative stress damage. In this study, a nanozyme, PDA‐MnO 2 (PM), synthesized and encapsulated the needle tip layer bi‐layer GelMA microneedle patch (PbMP), has excellent mechanical properties can easily penetrate skin. study involving an SD rat model infected with S. aureus , PbMP significantly accelerated process bacterially challenged wounds, resulting better blood vessel growth, cell proliferation, collagen biosynthesis than other dressings. The experiment shows that PM nanoparticles improve photothermal conversion efficiency activate SOD CAT, efficient cascade enzyme reaction system to eliminate ROS PTT process. This describes highly effective nanozyme hydrogel platform synergistic antibacterial effects on healing.

Язык: Английский

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Polymerized Network-Based Artificial Peroxisome Reprogramming Macrophages for Photoacoustic Imaging-Guided Treatment of Rheumatoid Arthritis

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(20), С. 25856 - 25868

Опубликована: Май 10, 2024

Artificial peroxisomes (AP) with enzyme-mimetic catalytic activity and recruitment ability have drawn a great deal of attention in fabricating protocell systems for scavenging reactive oxygen species (ROS), modulating the inflammatory microenvironment, reprogramming macrophages, which is potential treating diseases such as rheumatoid arthritis (RA). Herein, macrophage membrane-cloaked Cu-coordinated polyphthalocyanine-based AP (CuAP) prepared macrocyclic conjugated polymerized network embedded Cu-single atomic active center, mimics coordination environment natural superoxide dismutase catalase, possesses performs photoacoustic imaging (PAI)-guided treatment. The results both vitro cellular vivo animal experiments demonstrated that CuAP under ultrasound microbubbles could efficiently scavenge excess ROS cells tissues, modulate microenvironmental cytokines interleukin-1β, tumor necrosis factor-α, arginase-1, reprogram macrophages by polarization M1 (proinflammatory phenotype) to M2 (anti-inflammatory phenotype). We believe this study offers proof concept engineering multifaceted promising approach PAI-guided treatment platform RA.

Язык: Английский

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H₂O₂ Self‐Supplied MoS₂/CaO₂ Nanozyme Hydrogel with Near‐Infrared Photothermal Synergetic Cascade Peroxidase‐Like Activity for Wound Disinfection

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 6, 2024

Abstract In wound healing and clinical anti‐infection therapy, the current feasibility of nanocatalysts is extremely limited because inadequate reactive oxygen species (ROS) generation. Herein, a novel H 2 O self‐supplying nanocomposite (M/C/AEK) consists molybdenum disulfide (MoS ) decorated with calcium peroxide (CaO prepared at ambient temperature encapsulated in AEK hydrogel. presence poly(vinyl pyrrolidone) (PVP), CaO nanoclusters, ≈30 nm, are anchored on MoS surface. /CaO can induce both cascaded peroxidase (POD)‐like catalase (CAT)‐like catalytic activity to produce toxic hydroxyl radicals through self‐supplied responsive faintly acidic environment acute wounds. The POD‐like increased under compared neutral conditions, allowing selective treatment acute, slightly wounds while avoiding side effects high‐concentration antibacterial agents normal tissues. high near‐infrared photothermal effect synergistically POD‐like/CAT‐like boosts production more ROS eradicate Staphylococcus aureus Escherichia coli bacteria (98.6% 98.9%) effectively selectively stimulate healing. porous M/C/AEK hydrogel microenvironment efficiently capture bacteria, its Ca 2+ ions keratin healing, revealing excellent potential advanced care infection control therapies.

Язык: Английский

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Multifunctional carboxymethyl chitosan/oxidized carboxymethyl cellulose hydrogel loaded with ginsenoside Rg1 and polydopamine nanoparticles for infected diabetic wound healing

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136686 - 136686

Опубликована: Окт. 1, 2024

Язык: Английский

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Selective and complementary antimicrobial and antiviral activity of silver, copper, and selenium nanoparticle suspensions in deep eutectic solvent

Environmental Research, Год журнала: 2024, Номер 264, С. 120351 - 120351

Опубликована: Ноя. 12, 2024

Язык: Английский

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