ACS Materials Letters,
Год журнала:
2024,
Номер
7(1), С. 1 - 23
Опубликована: Ноя. 21, 2024
With
the
continuous
increase
in
average
life
expectancy,
population
aging
has
become
a
significant
health
issue
21st
century.
The
rising
prevalence
of
age-related
diseases
brought
tremendous
pressure
on
social
medical
systems
and
economy.
Against
this
backdrop,
research
anticellular
hot
spot
field
biomedicine,
biomaterials
are
showing
new
trends
potential
area.
Compared
to
drugs
other
traditional
anti-aging
strategies,
can
be
personalized
target
characteristics
different
tissues,
serving
as
drug
delivery
carriers
enhance
targeting,
directly
influence
cellular
process
by
modulating
microenvironment.
Furthermore,
offer
innovative
approaches
diagnosing
building
sophisticated
models,
which
our
understanding
biology
behind
speed
up
advancement
novel
treatments.
This
review
synthesizes
latest
advancements
biomaterial
for
combating
aging,
exploring
future
prospects
challenges.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(16)
Опубликована: Апрель 2, 2024
Atherosclerotic
plaque
formation
is
considered
the
primary
pathological
mechanism
underlying
atherosclerotic
cardiovascular
diseases,
leading
to
severe
events
such
as
stroke,
acute
coronary
syndromes,
and
even
sudden
cardiac
death.
Early
detection
timely
intervention
of
plaques
are
challenging
due
lack
typical
symptoms
in
initial
stages.
Therefore,
precise
early
play
a
crucial
role
risk
stratification
achieving
favorable
post-interventional
outcomes.
The
continuously
advancing
nanoplatforms
have
demonstrated
numerous
advantages
including
high
signal-to-noise
ratio,
enhanced
bioavailability,
specific
targeting
capabilities
for
imaging
agents
therapeutic
drugs,
enabling
effective
visualization
management
plaques.
Motivated
by
these
superior
properties,
various
noninvasive
modalities
recognition
preliminary
stage
atherosclerosis
comprehensively
summarized.
Additionally,
several
strategies
proposed
enhance
efficacy
treating
Finally,
existing
challenges
promising
prospects
accelerating
clinical
translation
nanoplatform-based
molecular
therapy
discussed.
In
conclusion,
this
review
provides
an
insightful
perspective
on
diagnosis
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 12, 2024
Endothelial
cells
(ECs)
are
pivotal
in
maintaining
vascular
health,
regulating
hemodynamics,
and
modulating
inflammatory
responses.
Nanocarriers
hold
transformative
potential
for
precise
drug
delivery
within
the
system,
particularly
targeting
ECs
therapeutic
purposes.
However,
complex
interactions
between
nanocarriers
present
significant
challenges
development
clinical
translation
of
nanotherapeutics.
This
review
assesses
recent
advancements
key
strategies
employing
to
ECs.
It
suggested
that
through
physicochemical
design
surface
modifications,
can
enhance
specificity
improve
internalization
efficiency
Additionally,
we
elaborated
on
applications
specifically
designed
treatment
cardiovascular
diseases,
cancer
metastasis,
disorders.
Despite
these
advancements,
safety
concerns,
complexity
vivo
processes,
challenge
achieving
subcellular
remain
obstacles
effective
with
nanocarriers.
A
comprehensive
understanding
endothelial
cell
biology
its
interaction
is
crucial
realizing
full
targeted
systems.
Antioxidants,
Год журнала:
2024,
Номер
13(5), С. 599 - 599
Опубликована: Май 13, 2024
Background:
The
discovery
of
traditional
plants’
medicinal
and
nutritional
properties
has
opened
up
new
avenues
for
developing
pharmaceutical
dietary
strategies
to
prevent
atherosclerosis.
However,
the
effect
antioxidant
Dendrobium
officinale
polysaccharide
(DOP)
on
atherosclerosis
is
still
not
elucidated.
Purpose:
This
study
aims
investigate
inhibitory
potential
mechanism
DOP
high-fat
diet-induced
in
Apolipoprotein
E
knockout
(ApoE−/−)
mice.
Study
design
methods:
identification
was
measured
by
high-performance
gel
permeation
chromatography
(HPLC)
Fourier
transform
infrared
spectroscopy
(FTIR).
We
used
diet
(HFD)-induced
ApoE−/−
mice
as
an
animal
model.
In
intervention
stage,
group
treated
gavage
with
200
μL
mg/kg
at
regular
times
each
day
continued
eight
weeks.
detected
changes
serum
lipid
profiles,
inflammatory
factors,
anti-inflammatory
capacity
host
metabolism.
also
determined
microbial
composition
using
16S
rRNA
gene
sequencing
whether
could
improve
structure
gut
microbiota
atherosclerotic
Results:
effectively
inhibited
histopathological
deterioration
significantly
reduced
levels,
malondialdehyde
(F/B)
production.
Additionally,
levels
factors
activity
enzymes,
including
superoxide
dismutase
(SOD)
glutathione
peroxidase
(GSH-PX),
were
increased
after
intervention.
Furthermore,
we
found
that
restructures
decreasing
Firmicutes/Bacteroidota
ratio.
Spearman’s
correlation
analysis
indicated
activity,
pro-/anti-inflammatory
associated
Firmicutes,
Bacteroidota,
Allobaculum,
Coriobacteriaceae_UCG-002.
Conclusions:
suggests
be
developed
a
food
prebiotic
treatment
future.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Март 1, 2024
Cancer
is
a
leading
cause
of
death
worldwide,
and
the
development
new
diagnostic
treatment
methods
crucial.
Manganese-based
nanomaterials
(MnNMs)
have
emerged
as
focal
point
in
field
cancer
diagnosis
due
to
their
multifunctional
properties.
These
been
extensively
explored
contrast
agents
for
various
imaging
technologies
such
magnetic
resonance
(MRI),
photoacoustic
(PAI),
near-infrared
fluorescence
(NIR-FL).
The
use
these
has
significantly
enhanced
precise
tumor
detection
localization.
Moreover,
MnNMs
shown
responsiveness
microenvironment
(TME),
enabling
innovative
approaches
treatment.
This
review
provides
an
overview
latest
developments
potential
applications
therapy.
Finally,
challenges
prospects
clinical
are
discussed.
We
believe
that
this
would
serve
valuable
resource
guiding
further
research
on
application
manganese
treatment,
addressing
current
limitations,
proposing
future
directions.
