Опубликована: Янв. 1, 2024
Язык: Английский
Small Methods, Год журнала: 2024, Номер unknown
Опубликована: Июль 23, 2024
Abstract Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications disease treatment. HA possesses good biocompatibility, biodegradability, and ability to interact various cell surface receptors. Its wide range of molecular weights modifiable chemical groups make it an effective drug carrier for delivery. Additionally, overexpression specific receptors on surfaces many states enhances accumulation drugs at pathological sites through receptor binding. In this review, modification drugs, major proteins, latest advances receptor‐targeted nano delivery systems (DDS) treatment tumors inflammatory diseases are summarized. Furthermore, functions varying vivo selection methods different discussed.
Язык: Английский
Процитировано
15
Advanced Science, Год журнала: 2024, Номер 11(38)
Опубликована: Авг. 9, 2024
Ferroptosis, an iron- and reactive oxygen species (ROS)-dependent cell death, holds significant promise for tumor therapy due to its ability induce lipid peroxidation (LPO) trigger antitumor immune responses. However, elevated cholesterol levels in cancer cells impede ferroptosis compromise function. Here, a novel nanozyme, Fe-MOF/CP, composed of iron metal-organic framework (Fe-MOF) nanoparticles loaded with oxidase PEGylation integrated immunotherapy is introduced. Fe-MOF/CP depletes generates hydrogen peroxide, enhancing ROS inducing LPO, thereby promoting ferroptosis. This process disrupts raft integrity downregulates glutathione peroxidase 4 suppressor protein 1, further facilitating Concurrently, augments immunogenic reduces programmed death-ligand 1 expression, revitalizes exhausted CD8
Язык: Английский
Процитировано
12
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159825 - 159825
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
ACS Materials Letters, Год журнала: 2024, Номер 6(6), С. 2165 - 2173
Опубликована: Май 3, 2024
Chemodynamic therapy (CDT) offers an effective in situ activation for cancer treatments. However, the efficiency of CDT is limited by antioxidant system within tumor cells, including antioxidative niacinamide adenine dinucleotide phosphate (NADPH) and glutathione (GSH). Zeolitic imidazolate framework-8 (ZIF-8) widely used therapies due to its tunable structure properties, but ZIF-8 itself lacks application. In order meet application demand CDT, we select Cu2+ ions that can catalyze a Fenton-like reaction 2-nitroimidazole (2-NI) consume NADPH as new inorganic–organic connection components. Based on reasonable coordination mode ZIF-8, nanoplatform with adjustable size constructed. The synthesized Cu-NI NPs are triple responsive hypoxia, GSH, hydrogen peroxide (H2O2), which selectively enhance Cu+/Cu2+-mediated induce apoptosis/ferroptosis. This work will promote diversification structures provide good implications realization enhanced CDT.
Язык: Английский
Процитировано
6
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(26), С. 33021 - 33037
Опубликована: Июнь 18, 2024
Hypoxia can lead to liver fibrosis and severely limits the efficacy of photodynamic therapy (PDT). Herein, carbon nitride (CN)-based hybrid nanoparticles (NPs) VPSGCNs@TSI for light-driven water splitting were utilized solve this problem. CNs doped with selenide glucose (Se-glu) enhance their red/NIR region absorption. Then, vitamin A-poly(ethylene glycol) (VA-PEG) fragments aggregation-induced emission (AIE) photosensitizers TSI introduced into Se-glu-doped CN NPs (VPSGCNs) construct NPs. The introduction VA-PEG enhanced targeting activated hepatic stellate cells (HSCs) reduced toxicity ordinary cells. VPSGCN units could trigger generate O2 under 660 nm laser irradiation, improve hypoxic environment site, downregulate HIF-1α expression, activate HSC ferroptosis via HIF-1α/SLC7A11 pathway. In addition, generated also increase reactive oxygen species (ROS) production in a environment, thereby completely reversing hypoxia-triggered PDT resistance effect. combination water-splitting materials showed 1 + > 2 effect increasing levels fibrosis, promoting HSCs caused by hypoxia.
Язык: Английский
Процитировано
6
Journal of Controlled Release, Год журнала: 2024, Номер 369, С. 517 - 530
Опубликована: Апрель 8, 2024
Язык: Английский
Процитировано
4
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Май 9, 2025
Photodynamic therapy (PDT) has been employed as a noninvasive treatment option for bladder cancer due to its controllability and minimal toxicity. However, the efficacy of PDT is often compromised by hypoxic microenvironment solid tumors. To address this challenge, our research dedicated developing Ru-Se-Ce6 nanoreactor that combines photoresponsiveness Ru-Se coordination bonds reactive oxygen species (ROS) triggered diselenide bonds, achieving dual-controlled release photosensitizer enhance effectiveness. The photoresponsive catalytic characteristics were validated through synchrotron radiation density functional theory calculations. Under laser irradiation, metal-to-ligand charge transfer (MLCT) within ruthenium complex leads cleavage bond, resulting in liberation complex, which significantly improves O2 generation from H2O2 tumor (TME). In vivo assessments demonstrated disrupted mitochondrial membrane potential via excessive ROS production, leading cell cycle arrest apoptosis. Additionally, revealed significant suppression subcutaneous orthotopic models while exhibiting good biocompatibility. These findings propose potent innovative approach therapy.
Язык: Английский
Процитировано
0
Acta Materia Medica, Год журнала: 2025, Номер 4(3)
Опубликована: Янв. 1, 2025
Tumor ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, has emerged as promising therapeutic strategy for combating cancers, particularly in cases involving cancer stem cells (CSCs) and drug resistance. In recent years nanomaterial-based approaches have gained significant attention the potential to selectively induce ferroptosis while sparing normal tissues. This review aims provide comprehensive overview current state-of-the-art utilizing nanomaterials targeting tumor with specific focus on application eradicating CSCs overcoming resistance mechanisms. The molecular mechanisms underlying induction nanomaterials, unique properties functionalities various nanomaterial platforms, strategies using nanoferroptosis will be discussed. addition, preclinical clinical evidence supporting efficacy platforms evaluated. Furthermore, challenges future perspectives development translation nanoferroptosis-based therapies precision treatment highlighted.
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Nanozymes combat oxidative stress-related diseases via surface functionalization strategies (chemical conjugation, physical encapsulation, and drug loading) to enable ROS scavenging, efficient delivery, synergistic therapy.
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 18, 2025
Abstract The rapid healing of infected wounds holds immense significance for patients suffering from persistent inflammation, which could lead to disability or even mortality if left unaddressed. However, current therapeutic modalities face formidable challenges in effectively addressing the complex pathogenesis chronic wounds. Herein, a robust strategy is reported combine synergistic photodynamic and piezocatalytic therapies through piezo‐phototronic effect efficient wound healing. approach capitalizes on flexible organic/inorganic piezoelectric film composed poly(vinylidene fluoride‐trifluoroethylene) (P(VDF‐TrFE)) zinc oxide (ZnO) nanorods as substrate. Additionally, tetraphenylporphyrin (TPP), photosensitizer, integrated into P(VDF‐TrFE)/ZnO framework create composite film, P(VDF‐TrFE)/ZnO/TPP. This generates both field reactive oxygen species (ROS) upon mechanical deformation, built‐in further enhances ROS production by photosensitizers light exposure. Both vivo vitro experiments demonstrate that significantly accelerated with combined illumination stimulation, showcasing profound work not only elucidates mechanisms underlying these coupled but also introduces an practical method treating routine outdoor activities under sunlight.
Язык: Английский
Процитировано
0