Journal of Colloid and Interface Science, Год журнала: 2024, Номер 679, С. 929 - 938
Опубликована: Окт. 25, 2024
Язык: Английский
Drug Delivery, Год журнала: 2025, Номер 32(1)
Опубликована: Март 24, 2025
Posterior segment eye diseases represent the leading causes of vision impairment and blindness globally. Current therapies still have notable drawbacks, including need for frequent invasive injections associated risks severe ocular complications. Recently, utility external stimuli, such as light, ultrasound, magnetic field, electric has been noted a promising strategy to enhance drug delivery posterior eye. In this review, we briefly summarize main physiological barriers against delivery, focusing primarily on recent advancements that utilize stimuli improve treatment outcomes diseases. The advantages these stimuli-responsive strategies are discussed, with illustrative examples highlighting improved tissue penetration, enhanced control over release, targeted lesions through minimally routes. Finally, discuss challenges future perspectives in translational research platforms, aiming bridge existing gaps toward clinical use.
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер 12(19)
Опубликована: Апрель 15, 2025
Biomaterials are increasingly used as implants in the body, but they often elicit tissue reactions due to immune system recognizing them foreign bodies. These typically involve activation of innate immunity and initiation an inflammatory response, which can persist chronic inflammation, causing implant failure. To reduce these risks, various strategies have been developed modify material composition, surface characteristics, or mechanical properties biomaterials. Moreover, bioactive materials emerged a new class biomaterials that induce desirable responses form strong bond between host tissue. In recent years, different immunomodulatory incorporated into drug delivery systems. Furthermore, more advanced molecule cell-based immunomodulators integrated with emerging will enable better control response improve function longevity and, ultimately, outcome biomaterial-based therapies.
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер 383, С. 113787 - 113787
Опубликована: Апрель 29, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 315, С. 144489 - 144489
Опубликована: Май 21, 2025
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Май 24, 2025
Abstract Neural networks are found to play an important role in monitoring and coordinating cardiac physiological activities. However, the clinical use of neuroregulatory strategies for repairing infarcted myocardium, such as vagus nerve stimulation pharmacological activation, confronts challenges managing signals potential drug side effects. In this study, innovative myocardial infarction repair strategy by creating a “pre‐neuralized” scaffold that combines strontium silicate microparticles with neural stem cells (NSCs) is introduced. Strontium promotes NSCs differentiation, resulting enriched mature neurons. This exhibits capabilities enhance maturation synchronized contraction cardiomyocytes, facilitating improving function vivo. The findings indicate pre‐neuralized aids recovery modulating genes linked circadian rhythm, underscoring strategic benefit neural‐induced regulation tissue repair. conclusion, study presents promising approach myocardium using inorganic biomaterial‐induced scaffolds neuromodulatory properties from perspective systemically regulation. work may offer new addressing complex organ injuries.
Язык: Английский
Процитировано
0
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 20, С. 1 - 24
Опубликована: Дек. 31, 2024
Abstract: Amphiphilic copolymers are composed of both hydrophilic and hydrophobic chains, which can self-assemble into polymeric micelles in aqueous solution via the hydrophilic/hydrophobic interactions. Due to their unique properties, have been widely used as drug carriers. Poorly soluble drugs be covalently attached polymer chains or non-covalently incorporated micelles, with improved pharmacokinetic profiles enhanced efficacy. In recent years, stimuli-responsive amphiphilic copolymer attracted significant attention. These respond specific stimuli, including physical triggers (light, temperature, etc). chemical stimuli (pH, redox, physiological factors (enzymes, ATP, Under these structures properties change, enabling targeted therapy controlled release tumors. strategies offer new avenues approaches enhance tumor efficacy reduce side effects. We will review applications different types therapy, aiming provide valuable guidance for future research directions clinical translation. Keywords: stimuli-responsive, delivery system
Язык: Английский
Процитировано
2
Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 245, С. 114205 - 114205
Опубликована: Сен. 3, 2024
Язык: Английский
Процитировано
1
Gels, Год журнала: 2024, Номер 10(12), С. 821 - 821
Опубликована: Дек. 13, 2024
Chinese herbal medicine has offered an enormous source for developing novel bio-soft materials. In this research, the natural polysaccharide isolated from Dendrobium was employed as secondary building block to fabricate a “hybrid” hydrogel with synthetic poly (vinyl alcohol) (PVA) polymers. Thanks presence of mannose units that contain cis-diol motifs on chain polysaccharides, efficient crosslinking borax is allowed and reversible covalent borate ester bonds are formed. Eventually, highly dynamic double-networked hydrogels were successfully prepared by integration polysaccharides PVA. Interestingly, introduction given rise more robust networks, leading enhanced thermal stability, mechanical strength, tensile capacity (>1000%) well rapid self-healing ability (<5 s) compared PVA/borax single networked hydrogel. Moreover, polysaccharides/PVA double network showed selective antibacterial activity towards S. aureus. The reported would provide scaffold hybridize bioactive polymers but multiple tailorable biomedical applications.
Язык: Английский
Процитировано
1
Journal of Colloid and Interface Science, Год журнала: 2024, Номер 679, С. 929 - 938
Опубликована: Окт. 25, 2024
Язык: Английский
Процитировано
0