Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
Abstract
Photothermal
therapy
(PTT),
as
an
innovative
optical
tumor
treatment
strategy,
is
characterized
by
its
minimal
invasiveness,
high
selectivity,
long‐lasting
efficacy,
and
safety,
has
attracted
widespread
attention.
However,
in
order
to
effectively
kill
cancer
cells,
a
higher
local
temperature
very
necessary,
which
inevitably
results
severe
stress
responses
cell
death,
thereby
triggering
harmful
inflammation.
Additionally,
achieving
effective
controlled
release
of
drugs
the
microenvironment
reduce
systemic
side
effects
still
major
challenge.
Herein,
intelligent
nanoplatform
first
reported,
featured
sulfide
iron
(FeS)
nanosheets
core,
loaded
with
perfluorohexane
(PFH),
skillfully
coated
polydopamine
(PDA).
It
can
serve
generator
reactive
oxygen
species
(ROS)
induce
ferroptosis,
further
intensifying
PTT,
ROS
eliminator
normal
tissue
control
undesired
inflammatory
response
during
differential
strategy
between
surrounding
tissue.
Meanwhile,
combination
ultrasound‐targeted
microbubble
destruction
(UTMD)
technology
significantly
enhanced
penetration
drug.
Overall,
delivery
FeS/PFH@PDA
combined
UTMD
achieve
precise
efficient
synergistic
for
tumors
demonstrate
outstanding
ultrasound
MR
dual‐mode
imaging
performance.
