Role of Gut Microbial Metabolites in Ischemic and Non-Ischemic Heart Failure
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2242 - 2242
Опубликована: Март 2, 2025
The
effect
of
the
gut
microbiota
extends
beyond
their
habitant
place
from
gastrointestinal
tract
to
distant
organs,
including
cardiovascular
system.
Research
interest
in
relationship
between
heart
and
has
recently
been
emerging.
secretes
metabolites,
Trimethylamine
N-oxide
(TMAO),
short-chain
fatty
acids
(SCFAs),
bile
(BAs),
indole
propionic
acid
(IPA),
hydrogen
sulfide
(H2S),
phenylacetylglutamine
(PAGln).
In
this
review,
we
explore
accumulating
evidence
on
role
these
secreted
metabolites
pathophysiology
ischemic
non-ischemic
failure
(HF)
by
summarizing
current
knowledge
clinical
studies
experimental
models.
Elevated
TMAO
contributes
HF
through
TGF-ß/Smad
signaling-mediated
myocardial
hypertrophy
fibrosis,
impairments
mitochondrial
energy
production,
DNA
methylation
pattern
change,
intracellular
calcium
transport.
Also,
high-level
can
promote
via
inflammation,
histone
methylation-mediated
vascular
platelet
hyperactivity,
thrombosis,
as
well
cholesterol
accumulation
activation
MAPK
signaling.
Reduced
SCFAs
upregulate
Egr-1
protein,
T-cell
infiltration,
HDAC
5
6
activities,
leading
HF,
while
reactive
oxygen
species
production
hyperactivation
caveolin-ACE
axis
result
HF.
An
altered
BAs
level
worsens
contractility,
opens
permeability
transition
pores
inducing
apoptosis,
enhances
accumulation,
eventually
exacerbating
IPA,
inhibition
nicotinamide
N-methyl
transferase
expression
increased
nicotinamide,
NAD+/NADH,
SIRT3
levels,
ameliorate
HF;
meanwhile,
H2S
suppressing
Nox4
ROS
stimulating
PI3K/AKT
pathway
also
protect
against
Furthermore,
PAGln
affect
sarcomere
shortening
ability
myocyte
contraction.
This
emerging
field
research
new
avenues
for
therapies
restoring
dietary
interventions,
prebiotics,
probiotics,
or
fecal
transplantation
such
normalizing
circulating
levels
TMAO,
SCFA,
BAs,
H2S,
PAGln.
Язык: Английский
Intestinal Insights: The Gut Microbiome’s Role in Atherosclerotic Disease: A Narrative Review
Microorganisms,
Год журнала:
2024,
Номер
12(11), С. 2341 - 2341
Опубликована: Ноя. 16, 2024
Recent
advances
have
highlighted
the
gut
microbiota
as
a
significant
contributor
to
development
and
progression
of
atherosclerosis,
which
is
an
inflammatory
cardiovascular
disease
(CVD)
characterized
by
plaque
buildup
within
arterial
walls.
The
microbiota,
consisting
diverse
collection
microorganisms,
impacts
host's
metabolism,
immune
responses,
lipid
processing,
all
contribute
atherosclerosis.
This
review
explores
complex
mechanisms
through
dysbiosis
promotes
atherogenesis.
We
emphasize
potential
integrating
modulation
with
traditional
care,
offering
holistic
approach
managing
Important
pathways
involve
translocation
microbial
components,
metabolism
metabolites
such
trimethylamine-N-oxide
(TMAO),
production
short-chain
fatty
acids
(SCFAs)
that
influence
vascular
health.
Studies
reveal
distinct
profiles
in
atherosclerosis
patients,
increased
pathogenic
bacteria
(
Язык: Английский
Probiotics: A Potential Strategy for Preventing and Managing Cardiovascular Disease
Nutrients,
Год журнала:
2024,
Номер
17(1), С. 52 - 52
Опубликована: Дек. 27, 2024
Probiotics
are
gaining
recognition
as
a
viable
strategy
for
mitigating
cardiovascular
risk
factors.
Specifically,
recent
studies
highlight
their
potential
benefits
in
managing
cholesterol
levels,
blood
pressure,
and
inflammation,
which
critical
components
the
prevention
of
diseases
(CVD).
This
comprehensive
review
aims
to
elucidate
impact
probiotic
consumption
on
major
factors,
including
individuals
with
hypertension,
type
II
diabetes
mellitus,
metabolic
syndrome,
hypercholesterolemia,
secondary
coronary
artery
disease.
Scientific
evidence
based
human
suggests
that
is
associated
positive
effects
anthropometric
measures,
inflammation
markers,
glucose
metabolism
lipid
profiles,
endothelial
function.
However,
these
findings
should
be
interpreted
pragmatically
acknowledge
significant
variability
results.
may
attributed
factors
such
composition
(single
strain
or
multiple
strains),
characteristics
delivery
matrix
(food,
capsules,
sachets),
duration
intervention,
dosage
regimen,
baseline
health
profiles
participants.
Incorporating
probiotics
part
healthy
lifestyle
approach
can
considered
feasible
both
management
CVD.
further
research
needed
influencing
effect
probiotics,
as:
(i)
optimal
strain(s),
(ii)
appropriate
dosage,
(iii)
treatment,
(iv)
vehicle,
(v)
sex-specific
differences.
Язык: Английский
Probiotics and Prebiotics: Meeting Dietary Requirements for Optimal Health and Planetary Sustainability
Journal of Nutrition,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Associations Between Microbiota Awareness, Healthy Eating Attitude, and Sociodemographic Factors in University Students
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(5)
Опубликована: Май 1, 2025
ABSTRACT
The
global
epidemic
of
diet‐related
chronic
diseases
emphasizes
the
significance
human
gut
microbiota
in
dietary
physiological
effects
and
etiology
diseases.
This
research
aimed
to
assess
relationship
between
awareness,
healthy
eating
attitudes,
sociodemographic
factors
university
students.
Two
hundred
forty‐two
students
participated
this
descriptive
analytical
study
Aydın
Ordu,
Türkiye.
University
completed
a
general
information
form,
anthropometric
measures,
Attitude
Scale
for
Healthy
Nutrition,
Microbiota
Awareness
Scale,
probiotic
prebiotic
food
frequency
questionnaire.
In
total,
48
(19.8%)
male
194
(80.2%)
female
study.
Nutrition
dietetics
had
higher
total
scores
sub‐factor
ASHN
awareness
lower
body
mass
index
compared
other
departments
(
p
<
0.05).
A
positive
significant
correlation
was
found
scores.
Conversely,
negative
statistically
observed
score
consumption
nutrition
departments.
studying
dietetic
department,
knowing
term
microbiota,
self‐assessment
on
knowledge
as
good
were
associated
with
increased
Given
association,
integrating
nutrition,
probiotics,
prebiotics
into
educational
curricula
all
departments,
scientific
conferences,
academic
may
enhance
among
Язык: Английский
Effects of Marine-Derived Components on Cardiovascular Disease Risk Factors and Gut Microbiota Diversity
Marine Drugs,
Год журнала:
2024,
Номер
22(11), С. 523 - 523
Опубликована: Ноя. 20, 2024
Cardiovascular
diseases
(CVDs),
which
comprise
coronary
heart
disease,
hypertension,
and
stroke,
collectively
represent
the
number
one
cause
of
death
globally.
Atherosclerosis
is
dominant
CVDs,
its
risk
factors
are
elevated
levels
low-density
lipoprotein
cholesterol
triglycerides,
cigarette
smoking,
obesity,
diabetes
mellitus.
In
addition,
diverse
evidence
highlights
role
played
by
inflammation
clonal
haematopoiesis,
eventually
leading
to
immunity
involvement.
The
human
microbiota
project
subsequent
studies
using
next-generation
sequencing
technology
have
indicated
that
thousands
different
microbial
species
present
in
gut.
Disturbances
gut
(GM)
composition,
i.e.,
dysbiosis,
been
associated
with
ranging
from
localised
gastrointestinal
disorders
metabolic
cardiovascular
illnesses.
Of
note,
experimental
suggested
GM,
host
immune
cells,
marine-derived
ingredients
work
together
ensure
intestinal
wall
integrity.
This
review
discusses
current
concerning
links
among
ingredients,
inflammatory
disease.
detail,
we
summarise
impact
fish-derived
proteins/peptides
algae
components
on
CVD
microbiome.
Furthermore,
describe
interplay
these
dietary
components,
probiotics/prebiotics,
CVDs.
Язык: Английский
Effects of Moderate Consumption of a Probiotic‐Fermented Sour Beer on the Inflammatory, Immunity, Lipid Profile, and Gut Microbiome of Healthy Men in a Participant‐Blinded, Randomized‐Controlled Within‐Subject Crossover Study
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(12), С. 10867 - 10880
Опубликована: Дек. 1, 2024
ABSTRACT
Probiotic
sour
beer
(PRO)
fermented
with
Lacticaseibacillus
paracasei
Lpc‐37
is
a
novel
beverage
option,
which
may
potentially
offer
health
benefits.
In
this
study,
the
effects
of
PRO
are
evaluated
on
inflammatory,
immunity,
lipid
profile,
and
gut
microbiome
consumers
in
5‐week,
participant‐blinded,
randomized‐controlled
within‐subject
crossover
study.
Twenty‐one
healthy
male
participants
consumed
330
mL
normal
(CON)
daily
for
2
weeks
each
1
week
washout.
Stool
blood
samples
were
collected
before
after
intervention.
Significant
increases
Proteobacteria
Bacteroides
significant
decrease
Dialister
(
p
<
0.05)
observed
CON
group,
while
populations
remained
relatively
stable
group.
A
increase
was
also
found
HDL‐cholesterol
0.05),
no
differences
inflammatory
immunity
profiles.
Further
research
warranted
to
explore
its
increasing
potential.
Язык: Английский