Effects of Moderate Consumption of a Probiotic‐Fermented Sour Beer on the Inflammatory, Immunity, Lipid Profile, and Gut Microbiome of Healthy Men in a Participant‐Blinded, Randomized‐Controlled Within‐Subject Crossover Study DOI Creative Commons
Sean Jun Leong Ou,

Hafizah Yusri,

Dimeng Yang

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(12), P. 10867 - 10880

Published: Dec. 1, 2024

ABSTRACT Probiotic sour beer (PRO) fermented with Lacticaseibacillus paracasei Lpc‐37 is a novel beverage option, which may potentially offer health benefits. In this study, the effects of PRO are evaluated on inflammatory, immunity, lipid profile, and gut microbiome consumers in 5‐week, participant‐blinded, randomized‐controlled within‐subject crossover study. Twenty‐one healthy male participants consumed 330 mL normal (CON) daily for 2 weeks each 1 week washout. Stool blood samples were collected before after intervention. Significant increases Proteobacteria Bacteroides significant decrease Dialister ( p < 0.05) observed CON group, while populations remained relatively stable group. A increase was also found HDL‐cholesterol 0.05), no differences inflammatory immunity profiles. Further research warranted to explore its increasing potential.

Language: Английский

Intestinal Insights: The Gut Microbiome’s Role in Atherosclerotic Disease: A Narrative Review DOI Creative Commons

Luana Alexandrescu,

Adrian Paul Suceveanu,

Alina Mihaela Stăniguţ

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2341 - 2341

Published: Nov. 16, 2024

Recent advances have highlighted the gut microbiota as a significant contributor to development and progression of atherosclerosis, which is an inflammatory cardiovascular disease (CVD) characterized by plaque buildup within arterial walls. The microbiota, consisting diverse collection microorganisms, impacts host's metabolism, immune responses, lipid processing, all contribute atherosclerosis. This review explores complex mechanisms through dysbiosis promotes atherogenesis. We emphasize potential integrating modulation with traditional care, offering holistic approach managing Important pathways involve translocation microbial components, metabolism metabolites such trimethylamine-N-oxide (TMAO), production short-chain fatty acids (SCFAs) that influence vascular health. Studies reveal distinct profiles in atherosclerosis patients, increased pathogenic bacteria (

Language: Английский

Citations

4
Role of Gut Microbial Metabolites in Ischemic and Non-Ischemic Heart Failure DOI Open Access
Mohammad Reza Hatamnejad,

Lejla Medzikovic,

Ateyeh Dehghanitafti

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2242 - 2242

Published: March 2, 2025

The effect of the gut microbiota extends beyond their habitant place from gastrointestinal tract to distant organs, including cardiovascular system. Research interest in relationship between heart and has recently been emerging. secretes metabolites, Trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), bile (BAs), indole propionic acid (IPA), hydrogen sulfide (H2S), phenylacetylglutamine (PAGln). In this review, we explore accumulating evidence on role these secreted metabolites pathophysiology ischemic non-ischemic failure (HF) by summarizing current knowledge clinical studies experimental models. Elevated TMAO contributes HF through TGF-ß/Smad signaling-mediated myocardial hypertrophy fibrosis, impairments mitochondrial energy production, DNA methylation pattern change, intracellular calcium transport. Also, high-level can promote via inflammation, histone methylation-mediated vascular platelet hyperactivity, thrombosis, as well cholesterol accumulation activation MAPK signaling. Reduced SCFAs upregulate Egr-1 protein, T-cell infiltration, HDAC 5 6 activities, leading HF, while reactive oxygen species production hyperactivation caveolin-ACE axis result HF. An altered BAs level worsens contractility, opens permeability transition pores inducing apoptosis, enhances accumulation, eventually exacerbating IPA, inhibition nicotinamide N-methyl transferase expression increased nicotinamide, NAD+/NADH, SIRT3 levels, ameliorate HF; meanwhile, H2S suppressing Nox4 ROS stimulating PI3K/AKT pathway also protect against Furthermore, PAGln affect sarcomere shortening ability myocyte contraction. This emerging field research new avenues for therapies restoring dietary interventions, prebiotics, probiotics, or fecal transplantation such normalizing circulating levels TMAO, SCFA, BAs, H2S, PAGln.

Language: Английский

Citations

0
Probiotics and Prebiotics: Meeting Dietary Requirements for Optimal Health and Planetary Sustainability DOI
Juan Chen, Yifei Yu,

Siyuan Sun

et al.

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Probiotics: A Potential Strategy for Preventing and Managing Cardiovascular Disease DOI Open Access
Anallely López‐Yerena, Victoria de Santisteban Villaplana, Lina Badimón

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 52 - 52

Published: Dec. 27, 2024

Probiotics are gaining recognition as a viable strategy for mitigating cardiovascular risk factors. Specifically, recent studies highlight their potential benefits in managing cholesterol levels, blood pressure, and inflammation, which critical components the prevention of diseases (CVD). This comprehensive review aims to elucidate impact probiotic consumption on major factors, including individuals with hypertension, type II diabetes mellitus, metabolic syndrome, hypercholesterolemia, secondary coronary artery disease. Scientific evidence based human suggests that is associated positive effects anthropometric measures, inflammation markers, glucose metabolism lipid profiles, endothelial function. However, these findings should be interpreted pragmatically acknowledge significant variability results. may attributed factors such composition (single strain or multiple strains), characteristics delivery matrix (food, capsules, sachets), duration intervention, dosage regimen, baseline health profiles participants. Incorporating probiotics part healthy lifestyle approach can considered feasible both management CVD. further research needed influencing effect probiotics, as: (i) optimal strain(s), (ii) appropriate dosage, (iii) treatment, (iv) vehicle, (v) sex-specific differences.

Language: Английский

Citations

2
Effects of Marine-Derived Components on Cardiovascular Disease Risk Factors and Gut Microbiota Diversity DOI Creative Commons
Ingrid Lamminpää, Amedeo Amedei, Cinzia Parolini

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(11), P. 523 - 523

Published: Nov. 20, 2024

Cardiovascular diseases (CVDs), which comprise coronary heart disease, hypertension, and stroke, collectively represent the number one cause of death globally. Atherosclerosis is dominant CVDs, its risk factors are elevated levels low-density lipoprotein cholesterol triglycerides, cigarette smoking, obesity, diabetes mellitus. In addition, diverse evidence highlights role played by inflammation clonal haematopoiesis, eventually leading to immunity involvement. The human microbiota project subsequent studies using next-generation sequencing technology have indicated that thousands different microbial species present in gut. Disturbances gut (GM) composition, i.e., dysbiosis, been associated with ranging from localised gastrointestinal disorders metabolic cardiovascular illnesses. Of note, experimental suggested GM, host immune cells, marine-derived ingredients work together ensure intestinal wall integrity. This review discusses current concerning links among ingredients, inflammatory disease. detail, we summarise impact fish-derived proteins/peptides algae components on CVD microbiome. Furthermore, describe interplay these dietary components, probiotics/prebiotics, CVDs.

Language: Английский

Citations

1
Effects of Moderate Consumption of a Probiotic‐Fermented Sour Beer on the Inflammatory, Immunity, Lipid Profile, and Gut Microbiome of Healthy Men in a Participant‐Blinded, Randomized‐Controlled Within‐Subject Crossover Study DOI Creative Commons
Sean Jun Leong Ou,

Hafizah Yusri,

Dimeng Yang

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(12), P. 10867 - 10880

Published: Dec. 1, 2024

ABSTRACT Probiotic sour beer (PRO) fermented with Lacticaseibacillus paracasei Lpc‐37 is a novel beverage option, which may potentially offer health benefits. In this study, the effects of PRO are evaluated on inflammatory, immunity, lipid profile, and gut microbiome consumers in 5‐week, participant‐blinded, randomized‐controlled within‐subject crossover study. Twenty‐one healthy male participants consumed 330 mL normal (CON) daily for 2 weeks each 1 week washout. Stool blood samples were collected before after intervention. Significant increases Proteobacteria Bacteroides significant decrease Dialister ( p < 0.05) observed CON group, while populations remained relatively stable group. A increase was also found HDL‐cholesterol 0.05), no differences inflammatory immunity profiles. Further research warranted to explore its increasing potential.

Language: Английский

Citations

0