Metabolic-Dysfunction-Associated Steatotic Liver Disease: Molecular Mechanisms, Clinical Implications, and Emerging Therapeutic Strategies
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2959 - 2959
Опубликована: Март 25, 2025
Metabolic-dysfunction-associated
steatotic
liver
disease
(MASLD),
previously
known
as
non-alcoholic
fatty
(NAFLD),
is
a
highly
prevalent
metabolic
disorder
characterized
by
hepatic
steatosis
in
conjunction
with
at
least
one
cardiometabolic
risk
factor,
such
obesity,
type
2
diabetes,
hypertension,
or
dyslipidemia.
As
global
rates
of
obesity
and
syndrome
continue
to
rise,
MASLD
becoming
major
public
health
concern,
projections
indicating
substantial
increase
prevalence
over
the
coming
decades.
The
spectrum
ranges
from
simple
metabolic-dysfunction-associated
steatohepatitis
(MASH),
fibrosis,
cirrhosis,
hepatocellular
carcinoma,
contributing
significant
morbidity
mortality
worldwide.
This
review
delves
into
molecular
mechanisms
driving
pathogenesis,
including
dysregulation
lipid
metabolism,
chronic
inflammation,
oxidative
stress,
mitochondrial
dysfunction,
gut
microbiota
alterations.
Recent
advances
research
have
highlighted
role
genetic
epigenetic
factors
progression,
well
novel
therapeutic
targets
peroxisome
proliferator-activated
receptors
(PPARs),
fibroblast
growth
factors,
thyroid
hormone
receptor
beta
agonists.
Given
multifaceted
nature
MASLD,
multidisciplinary
approach
integrating
early
diagnosis,
insights,
lifestyle
interventions,
personalized
therapies
critical.
underscores
urgent
need
for
continued
innovative
treatment
strategies
precision
medicine
approaches
halt
progression
improve
patient
outcomes.
Язык: Английский
Antioxidant activity, microbial viability, and sensory attributes of traditional-yogurt enriched with silymarin
Cogent Food & Agriculture,
Год журнала:
2024,
Номер
10(1)
Опубликована: Окт. 29, 2024
Silymarin,
derived
from
Silybum
marianum
(milk
thistle)
seeds,
is
known
for
its
anti-oxidative
properties.
The
study
examines
how
various
concentrations
of
silymarin
(0,
25,
50,
and
100
mg/L)
affect
activity,
phenolic
content,
pH,
viscosity,
sensory
qualities,
Lactobacillus
delbrueckii
(L.
delbrueckii)
viability
in
yogurt
stored
7,
14,
21
days
at
4
°C,
aiming
to
understand
impact
on
quality
health-promoting
Antioxidant
activity
L.
fortified
were
increased
(58.26
mg
GAE/g
17.45%)
with
increasing
the
concentration
while
decreasing
scores.
A
T3
(100
silymarin/L)
exhibited
viscosity
7.06
±
0.79
6.27
0.13
Pa·s
Days
1–21,
T0
(control)
had
higher
11.36
0.63
9.48
0.16
Pa·s.
Microbial
counts
decreased
4.7–7.14
7.6–12.3
log
CFU/g
by
predominant
Streptococcus
thermophilus
(S.
thermophiles)
bulgaricus
bulgaricus),
absence
coliforms,
minimal
mold
yeast
growth.
Initially,
T1
was
preferred
due
superior
flavor,
texture,
overall
acceptability
Controlled
addition
improves
yogurt's
antioxidant
bacterial
without
compromising
attributes,
making
it
a
promising
functional
food.
Язык: Английский
Determine The Effectiveness Of Balance In The Gut Microbiome And Some Blood Parameters In Obese Donors In Iraq
Deleted Journal,
Год журнала:
2024,
Номер
3(3), С. 355 - 361
Опубликована: Авг. 2, 2024
The
current
study
aimed
to
evaluate
the
relationship
between
intestinal
bacteria
and
some
blood
parameters
in
cases
of
obesity
Iraq.
included
60
samples.
Their
ages
ranged
from
both
sexes
(20-64)
years
(40)
samples
people
suffering
(Obesity
Group)
after
confirming
by
measuring
weight
height
extracting
value
Body
Mass
Index
(BMI)
(20)
with
ideal
as
a
control
group
(Control
Group).
found
that
obese
donors
had
decreased
values
mean
red
cell
volume,
packed
hemoglobin,
cells,
while
increased
platelets,
white
neutrophils,
lymphocytes.
results
showed
alanine
aminotransferase,
aspartate
alkaline
phosphatase.It
was
also
noted
through
there
an
increase
number
stool
compared
group.
Язык: Английский