Metabolic-Dysfunction-Associated Steatotic Liver Disease: Molecular Mechanisms, Clinical Implications, and Emerging Therapeutic Strategies

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2959 - 2959

Published: March 25, 2025

Metabolic-dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty (NAFLD), is a highly prevalent metabolic disorder characterized by hepatic steatosis in conjunction with at least one cardiometabolic risk factor, such obesity, type 2 diabetes, hypertension, or dyslipidemia. As global rates of obesity and syndrome continue to rise, MASLD becoming major public health concern, projections indicating substantial increase prevalence over the coming decades. The spectrum ranges from simple metabolic-dysfunction-associated steatohepatitis (MASH), fibrosis, cirrhosis, hepatocellular carcinoma, contributing significant morbidity mortality worldwide. This review delves into molecular mechanisms driving pathogenesis, including dysregulation lipid metabolism, chronic inflammation, oxidative stress, mitochondrial dysfunction, gut microbiota alterations. Recent advances research have highlighted role genetic epigenetic factors progression, well novel therapeutic targets peroxisome proliferator-activated receptors (PPARs), fibroblast growth factors, thyroid hormone receptor beta agonists. Given multifaceted nature MASLD, multidisciplinary approach integrating early diagnosis, insights, lifestyle interventions, personalized therapies critical. underscores urgent need for continued innovative treatment strategies precision medicine approaches halt progression improve patient outcomes.

Language: Английский

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Antioxidant activity, microbial viability, and sensory attributes of traditional-yogurt enriched with silymarin

Cogent Food & Agriculture, Journal Year: 2024, Volume and Issue: 10(1)

Published: Oct. 29, 2024

Silymarin, derived from Silybum marianum (milk thistle) seeds, is known for its anti-oxidative properties. The study examines how various concentrations of silymarin (0, 25, 50, and 100 mg/L) affect activity, phenolic content, pH, viscosity, sensory qualities, Lactobacillus delbrueckii (L. delbrueckii) viability in yogurt stored 7, 14, 21 days at 4 °C, aiming to understand impact on quality health-promoting Antioxidant activity L. fortified were increased (58.26 mg GAE/g 17.45%) with increasing the concentration while decreasing scores. A T3 (100 silymarin/L) exhibited viscosity 7.06 ± 0.79 6.27 0.13 Pa·s Days 1–21, T0 (control) had higher 11.36 0.63 9.48 0.16 Pa·s. Microbial counts decreased 4.7–7.14 7.6–12.3 log CFU/g by predominant Streptococcus thermophilus (S. thermophiles) bulgaricus bulgaricus), absence coliforms, minimal mold yeast growth. Initially, T1 was preferred due superior flavor, texture, overall acceptability Controlled addition improves yogurt's antioxidant bacterial without compromising attributes, making it a promising functional food.

Language: Английский

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Determine The Effectiveness Of Balance In The Gut Microbiome And Some Blood Parameters In Obese Donors In Iraq

Deleted Journal, Journal Year: 2024, Volume and Issue: 3(3), P. 355 - 361

Published: Aug. 2, 2024

The current study aimed to evaluate the relationship between intestinal bacteria and some blood parameters in cases of obesity Iraq. included 60 samples. Their ages ranged from both sexes (20-64) years (40) samples people suffering (Obesity Group) after confirming by measuring weight height extracting value Body Mass Index (BMI) (20) with ideal as a control group (Control Group). found that obese donors had decreased values mean red cell volume, packed hemoglobin, cells, while increased platelets, white neutrophils, lymphocytes. results showed alanine aminotransferase, aspartate alkaline phosphatase.It was also noted through there an increase number stool compared group.

Language: Английский

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