INCARE International Journal of Educational Resources,
Год журнала:
2024,
Номер
5(4), С. 386 - 409
Опубликована: Дек. 22, 2024
The
utilization
of
local
food
ingredients
is
often
neglected
in
everyday
life,
even
though
it
has
great
potential
to
strengthen
wisdom
values
among
the
community
and
increase
student
involvement
project-based
learning
activities.
One
that
rich
nutrients
but
underutilized
pumpkin,
which
a
good
source
beta-carotene
fiber
opportunity
be
developed
further.
This
study
applied
STEM
(Science,
Technology,
Engineering,
Mathematics)
approach
pumpkin
pudding
development
project
ingredients.
was
through
several
stages:
first,
from
science
aspect,
nutritional
composition
analyzed
maximize
its
health
benefits;
second,
technology
innovative
processing
techniques
were
used
optimize
taste
texture
pudding;
third,
engineering,
recipe
modifications
made
maintain
product
stability
durability;
fourth,
mathematics
calculating
exact
composition.
results
showed
not
only
high
value,
also
well
received
by
public,
especially
teenagers.
expected
inspire
similar
products
are
delicious
nutritious,
support
sustainability
an
integrated
approach.
Antioxidants,
Год журнала:
2025,
Номер
14(1), С. 70 - 70
Опубликована: Янв. 9, 2025
Oxidative
stress
(OS)
refers
to
the
production
of
a
substantial
amount
reactive
oxygen
species
(ROS),
leading
cellular
and
organ
damage.
This
imbalance
between
oxidant
antioxidant
activity
contributes
various
diseases,
including
cancer,
cardiovascular
disease,
diabetes,
neurodegenerative
conditions.
The
body’s
system,
mediated
by
signaling
pathways,
includes
AMPK-SIRT1-FOXO
pathway.
In
oxidative
conditions,
AMPK,
an
energy
sensor,
activates
SIRT1,
which
in
turn
stimulates
FOXO
transcription
factor.
cascade
enhances
mitochondrial
function,
reduces
damage,
mitigates
OS-induced
injury.
review
provides
comprehensive
analysis
biological
roles,
regulatory
mechanisms,
functions
pathway
diseases
influenced
OS,
offering
new
insights
methods
for
understanding
OS
pathogenesis
its
therapeutic
approaches.
Journal of Food Science,
Год журнала:
2025,
Номер
90(2)
Опубликована: Фев. 1, 2025
Abstract
Two
pretreatments
(ultrasound
sonication
[US]
and
microwave
[MW])
drying
techniques
(hot
air
[HA]
freeze‐drying
[FD])
were
used
to
assess
the
in
vitro
bioaccessibility
of
phenols,
carotenoids,
antioxidant
activity
three
tomato
cultivars
(Zzx171,
Zzx162,
Zzx65).
The
metabolome‐chemometric
analysis
showed
that
dried
by
FD
HA
differed
metabolites.
samples
contained
methoxytyrosine
aconitane‐type
diterpenoids.
US‐HA
enhanced
total
phenol
content
64.72%–74.25%
after
digestion
(intestinal
phase).
increased
protocatechuic
acid
levels
all
intestinal
phase,
but
55.23%
Zzx65
compared
undigested
samples.
Despite
adopted
postharvest
drying,
retained
chlorogenic
acid,
4‐
O
‐caffeinyliquinic
rutin
better,
due
microstructure
changes
treated
with
most.
In
samples,
US‐FD
improved
lycopene,
β‐carotene
retention,
inaccessibility
was
reduced
significantly
during
digestion.
Cultivar
×
treatment
affected
phenolic
compounds,
activities
phase.
had
power
(FRAP)
3‐ethylbenzothiazoline‐6‐sulfonic
(ABTS)
scavenging
Practical
Application
Tomatoes
are
an
important
part
human
diet.
Their
high
perishability
reduces
their
nutritional
microbiological
quality.
lack
cold
storage
infrastructure
developing
countries
contributes
food
waste.
Convective
hot
is
suitable
for
recycling
fresh
market
waste
products
as
supplement
powders.
ultrasound
pretreatment
protects
bioactive
compounds
fruit
non‐thermal.
There
several
limitations,
including
equipment
cost,
energy
efficiency,
integration
commercial
systems,
which
limit
ultrasound‐assisted
drying's
scalability.
(ultrasound‐assisted
drying)
could
reduce
contribute
sustainable
development
goals
agricultural
industries.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 279 - 279
Опубликована: Фев. 19, 2025
Type
2
diabetes
(T2D)
and
metabolic
(dysfunction)-associated
steatotic
liver
disease
(MASLD)
affect
a
growing
number
of
individuals
worldwide.
T2D
MASLD
often
coexist
substantially
elevate
the
risk
adverse
hepatic
cardiovascular
clinical
outcomes.
Several
common
pathogenetic
mechanisms
are
responsible
for
onset
progression,
including
insulin
resistance,
oxidative
stress,
low-grade
inflammation,
among
others.
The
latter
can
also
be
induced
by
gut
microbiota
its
derived
metabolites.
Natural
bioactive
compounds
(NBCs)
have
been
reported
their
therapeutic
potential
in
both
MASLD.
A
large
amount
evidence
obtained
from
trials
suggests
that
like
berberine,
curcumin,
soluble
fibers,
omega-3
fatty
acids
exhibit
significant
hypoglycemic,
hypolipidemic,
hepatoprotective
activity
humans
may
employed
as
adjunct
therapy
management.
In
this
review,
role
most
studied
NBCs
management
is
discussed,
emphasizing
recent
supporting
these
compounds'
efficacy
safety.
Also,
prebiotics
act
against
dysfunction
modulating
evaluated.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 286 - 286
Опубликована: Фев. 20, 2025
It
is
widely
recognized
that
prostate
cancer
a
multifaceted
illness
the
second
most
common
cause
of
cancer-related
fatalities
among
males.
Natural
sources
from
both
plants
and
marine
organisms
have
long
been
used
in
treating
various
diseases
discovery
new
pharmaceutical
compounds.
Medicinal
plants,
particular,
provide
bioactive
substances
like
alkaloids,
phenolic
compounds,
terpenes,
steroids.
In
addition,
natural
products
play
crucial
role
search
for
novel
treatments.
A
substantial
number
anticancer
drugs
derived
sources,
including
organisms,
microorganisms.
fact,
over
past
60
years,
80%
chemical
entities
originated
which
are
generally
considered
safer
than
synthetic
This
review
seeks
to
emphasize
phytochemical
compounds
plant
cancer,
highlighting
their
potential
therapeutic
impact.
also
intended
support
global
researchers
working
on
identification
natural-based
treatments
cancer.
Plants,
Год журнала:
2025,
Номер
14(6), С. 978 - 978
Опубликована: Март 20, 2025
Chloroplasts
are
important
in
plant
growth,
development,
and
defense
mechanisms,
making
them
central
to
addressing
global
agricultural
challenges.
This
review
explores
the
multi-faceted
contributions
of
chloroplasts,
including
photosynthesis,
hormone
biosynthesis,
stress
signaling,
which
orchestrate
trade-off
between
growth
defense.
Advancements
chloroplast
genomics,
transcription,
translation,
proteomics
have
deepened
our
understanding
their
regulatory
functions
interactions
with
nuclear-encoded
proteins.
Case
studies
demonstrated
potential
chloroplast-targeted
strategies,
such
as
expression
elongation
factor
EF-2
for
heat
tolerance
flavodiiron
proteins
drought
resilience,
enhance
crop
productivity
adaptation.
Future
research
directions
should
focus
on
need
integrating
omics
data
nanotechnology
synthetic
biology
develop
sustainable
resilient
systems.
uniquely
integrates
recent
advancements
transcriptional
regulation,
present
a
holistic
perspective
optimizing
tolerance.
We
emphasize
role
chloroplast-driven
balancing
immunity,
leveraging
technologies
emerging
biotechnological
innovations.
comprehensive
approach
offers
new
insights
into
practices,
it
significant
contribution
field.
Biomolecules,
Год журнала:
2025,
Номер
15(4), С. 486 - 486
Опубликована: Март 26, 2025
The
present
study
was
designed
to
characterize
the
interactions
between
lecithin
liposomes,
a
model
membrane,
and
either
β-carotene
or
tamoxifen.
In
addition,
cytotoxicity
of
liposomal
beta-carotene
with
tamoxifen
screened
in
vitro
human
breast
cancer
cell
lines
MCF-7
MDA-MB-231
addition
normal
WI38
line.
All
liposomes
were
nearly
spherical
evenly
distributed
had
fewer
aggregates
for
encapsulated
empty
vesicles.
Measurements
using
dynamic
light
scattering
verified
that
each
sample
monodisperse.
When
is
incorporated
into
membranes,
zeta
potential
values
tend
decrease.
test
treated
cells,
IC50
value
at
least
0.45
μg/mL,
whereas
free
cells
7.8
μg/mL.
For
tamoxifen,
9.92
but
its
form,
it
20.88
According
β-carotene,
15.5
38.1
12.1
21.2
11.4
respectively.
This
investigation
demonstrated
has
more
potent
cytotoxic
impact
than
findings
showed
comet
assay
variable
significantly
(p
<
0.05)
elevated
comparison
control
values.
Analysis
flow
cytometry
revealed
displayed
greater
degree
apoptosis
following
48
h
exposure
β-carotene.
Based
on
available
data,
novel
treatment
plan
includes
may
boost
antitumor
activity
toward
current
preparations
natural
products
might
be
good
substitute
pharmaceutical
interventions
cancer.
New Technologies,
Год журнала:
2025,
Номер
21(1), С. 25 - 40
Опубликована: Апрель 1, 2025
Introduction.
The
article
provides
an
overview
of
studies
on
the
effect
beta-carotene
consumer
properties
and
nutritional
value
confectionery,
dairy,
meat
oil
fat
products.
Information
modern
delivery
systems
to
be
included
in
food
has
been
presented.
goal
research
is
analyze
domestic
foreign
scientific
technical
literature
patent
information
field
application
technologies
substantiate
need
develop
functional
foods
enriched
with
beta-carotene.
Methods.
uses
methods
analysis,
systematization
generalization
available
data.
search
for
was
carried
out
Google
Scholar,
Scopus,
Web
Science
Elsevier
databases,
as
well
Scientific
Electronic
Library
eLIBRARY.RU.
Results.
It
established
that
used
a
additive
performing
role
both,
antioxidant
slowing
down
oxidation
processes
phase
products,
contributing
increase
their
shelf
life,
natural
dye
allowing
reduce
use
synthetic
dyes,
or
replace
sodium
nitrite
which
exhibits
carcinogenic
properties.
Thus,
ensuring
formation
required
quality
products
possessing
high
bio
potential.
Conclusion.
concluded
there
recipes
However,
effectiveness
depends
maintaining
its
stability,
since
it
tends
easily
destroyed
during
processing
storage
being
sensitive
such
factors
heat,
light
oxygen.
shown
most
promising
system
delivering
encapsulation
form
micro
emulsions,
allows
increasing
stability
bioavailability,
preservation
bioactive
potential
Agronomy,
Год журнала:
2025,
Номер
15(4), С. 933 - 933
Опубликована: Апрель 11, 2025
This
study
investigates
the
phytochemical
composition
and
cultivation
strategies
for
watermelon
(Citrullus
lanatus
(Thunb.))
in
Lithuania’s
temperate
climate,
focusing
on
its
biological
activity.
Employing
innovative
grafting
techniques
clear
plastic
film
mulching,
we
successfully
countered
fusarium
wilt
while
promoting
growth
bioactive
compound
accumulation.
Our
analysis
showed
significant
cultivar-dependent
variations
total
phenolic
content
(ranging
from
94.34
±
8.12
to
327.42
9.14
mg
GAE/kg
fw
pulps
120.46
7.52
364.27
6.85
rinds),
lycopene
1.15
0.42
103.60
1.69
mg/kg
pulps),
sugar,
nitrate
levels,
revealing
influence
of
genetics
environment
fruit’s
profile.
Moreover,
several
Lithuanian
cultivars
exhibited
comparable
or
superior
levels
key
compounds
relative
imported
varieties.
These
findings
underscore
potential
rind
pulp
as
valuable
sources
antioxidants
other
phytochemicals,
relevant
nutritional
enhancement
medicinal
applications.
The
results
contribute
a
deeper
understanding
Lithuania
highlight
opportunities
optimizing
agricultural
practices
enhance
health
benefits
associated
with
this
important
fruit.
