bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Март 7, 2023
Microglia
are
the
primary
phagocytes
in
central
nervous
system
and
responsible
for
clearing
dead
cells
generated
during
development
or
disease.
The
phagocytic
process
shapes
phenotype
of
microglia,
which
affects
local
environment.
A
unique
population
microglia
reside
ventricular-subventricular
zone
(V-SVZ)
neonatal
mice,
but
how
they
influence
this
neurogenic
niche
is
not
well-understood.
Here,
we
demonstrate
that
phagocytosis
creates
a
pro-neurogenic
microglial
V-SVZ
these
phagocytose
apoptotic
via
engulfment
receptor
Jedi-1.
Deletion
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
170, С. 115847 - 115847
Опубликована: Ноя. 27, 2023
Ischemic
stroke
is
one
of
the
most
cases
worldwide,
with
high
rate
morbidity
and
mortality.
In
pathological
process
ischemic
stroke,
neuroinflammation
an
essential
that
defines
functional
prognosis.
After
onset,
microglia,
astrocytes
infiltrating
immune
cells
contribute
to
a
complicated
cascade
play
roles
in
pathophysiological
variations
stroke.
Both
microglia
undergo
both
morphological
changes,
thereby
deeply
participate
neuronal
inflammation
via
releasing
pro-inflammatory
or
anti-inflammatory
factors.
Flavonoids
are
plant-specific
secondary
metabolites
can
protect
against
cerebral
ischemia
injury
modulating
inflammatory
responses.
For
instances,
quercetin
inhibit
expression
release
cytokines,
such
as
tumor
necrosis
factor
(TNF)-α,
IL-6
IL-1β,
nervous
system
(CNS).
Apigenin
rutin
promote
polarization
genotype
then
neuroinflammation.
this
review,
we
focused
on
dual
activated
reactive
astrocyte
following
discussed
anti-neuroinflammation
some
flavonoids.
Importantly,
aimed
reveal
new
strategies
for
alleviating
Expert Opinion on Therapeutic Targets,
Год журнала:
2024,
Номер
28(9), С. 739 - 755
Опубликована: Сен. 1, 2024
This
review
highlights
the
critical
role
of
endocannabinoid
system
(ECS)
in
regulating
neuropathic
pain
and
explores
therapeutic
potential
cannabinoids.
Understanding
mechanisms
ECS,
including
its
receptors,
endogenous
ligands,
enzymatic
routes,
can
lead
to
innovative
treatments
for
chronic
pain,
offering
more
effective
therapies
conditions.
bridges
gap
between
preclinical
studies
clinical
applications
by
emphasizing
ECS
modulation
better
management
outcomes.
Neurobiology of Disease,
Год журнала:
2023,
Номер
184, С. 106235 - 106235
Опубликована: Июль 21, 2023
Neurodegenerative
disorders
are
debilitating
conditions
that
impair
patient
quality
of
life
and
represent
heavy
social-economic
burdens
to
society.
Whereas
the
root
some
these
brain
illnesses
lies
in
autosomal
inheritance,
origin
most
neuropathologies
is
scantly
understood.
Similarly,
cellular
molecular
substrates
explaining
progressive
loss
functions
remains
be
fully
described
too.
Indeed,
study
neurodegeneration
has
resulted
a
complex
picture,
composed
myriad
altered
processes
include
broken
bioenergetics,
widespread
neuroinflammation
aberrant
activity
signaling
pathways.
In
this
context,
several
lines
research
have
shown
endocannabinoid
system
(ECS)
its
main
hub,
type-1
cannabinoid
(CB1)
receptor
diverse
neurodegenerative
disorders.
However,
data
conflictive
or
poorly
described.
review,
we
summarize
findings
about
alterations
ECS
CB1
receptors
three
representative
illnesses,
Alzheimer's,
Parkinson's
Huntington's
diseases,
discuss
relevance
studies
understanding
development
progression,
with
special
focus
on
astrocyte
function.
Noteworthy,
analysis
defects
warrant
much
more
studies,
as
our
conceptual
function
evolved
quickly
last
years,
which
now
glia
cells
subcellular-specific
critical
players
functions.
