Materials Today Bio, Год журнала: 2024, Номер 30, С. 101411 - 101411
Опубликована: Дек. 18, 2024
Язык: Английский
Advanced Science, Год журнала: 2024, Номер 11(14)
Опубликована: Фев. 2, 2024
Abstract The emergence of acute ischemic stroke (AIS) induced cardiovascular dysfunctions as a bidirectional interaction has gained paramount importance in understanding the intricate relationship between brain and heart. Post AIS, ensuing encompass spectrum complications, including heart attack, congestive failure, systolic or diastolic dysfunction, arrhythmias, electrocardiographic anomalies, hemodynamic instability, cardiac arrest, among others, all which are correlated with adverse outcomes mortality. Mounting evidence underscores intimate crosstalk brain, facilitated by physiological neurohumoral complex networks. primary pathophysiological mechanisms contributing to these severe complications involve hypothalamic‐pituitary‐adrenal (HPA) axis, sympathetic parasympathetic hyperactivity, immune inflammatory responses, gut dysbiosis, collectively shaping stroke‐related brain–heart axis. Ongoing research endeavors concentrated on devising strategies prevent AIS‐induced dysfunctions. Notably, labetalol, nicardipine, nitroprusside recommended for hypertension control, while β‐blockers employed avert chronic remodeling address arrhythmias. However, despite therapeutic interventions, targets remain elusive, necessitating further investigations into this challenge. This review aims delineate state‐of‐the‐art AIS through preclinical clinical research, unraveling their interplay within offering pragmatic suggestions managing
Язык: Английский
Процитировано
12
International Journal of Molecular Medicine, Год журнала: 2025, Номер 55(3)
Опубликована: Янв. 21, 2025
Ischemic stroke, a leading cause of disability and mortality worldwide, is characterized by the sudden loss blood flow in specific area brain. Intravenous thrombolysis with recombinant tissue plasminogen activator only approved pharmacological treatment for acute ischemic stroke; however, aforementioned has significant clinical limitations, thus there an urgent need development novel mechanisms therapeutic strategies stroke. Astrocytes, abundant versatile cells central nervous system, offer crucial support to neurons nutritionally, structurally physically. They also contribute blood‑brain barrier formation regulate neuronal extracellular ion concentrations. Accumulated evidence revealed involvement astrocytes regulation host neurotransmitter metabolism, immune response repair, different metabolic characteristics can process suggesting that targeted astrocyte reprogramming may prognosis In present review, current understanding multifaceted along its regulatory factors pathways, as well promote polarization balance, which hold promise immunometabolism‑targeted therapies were summarized.
Язык: Английский
Процитировано
1
Neuroscience, Год журнала: 2025, Номер 569, С. 161 - 183
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Авг. 8, 2024
This study aimed to investigate the regulatory role of astrocyte-derived exosomes and their microRNAs (miRNAs) in modulating neuronal pyroptosis during cerebral ischemia.
Язык: Английский
Процитировано
4
Brain Research, Год журнала: 2025, Номер unknown, С. 149528 - 149528
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Translational Research in Anatomy, Год журнала: 2025, Номер unknown, С. 100395 - 100395
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Phytotherapy Research, Год журнала: 2025, Номер unknown
Опубликована: Апрель 2, 2025
Spinal cord injury (SCI) is a serious neurological disease with an extremely high disability rate. Most patients show loss of motor and sensory functions below the level injury. Current treatment protocols are based on early surgical decompression pharmacotherapy. However, efficacy these interventions suboptimal. Due to its complex pathophysiological mechanisms difficulty central nervous system (CNS) regeneration, exploring effective therapeutic remains daunting. Flavonoids secondary metabolites unique plants that have attracted attention in recent years for their potential now commonly used inflammation, tumors, other diseases. For SCI, related studies still exploring; some compounds, such as quercetin, fisetin, hesperetin, shown good anti-inflammatory anti-apoptotic properties, which help restore function injured spinal cord. flavonoids exhibit certain disadvantages, including poor solubility, low bioavailability, inability achieve long-term controlled release. Some proposed drug delivery strategies-including nanoparticles, hydrogels, collagen scaffolds-to enhance efficacy. In this paper, we summarize strategies SCI by searching relevant literature propose future research directions provide new ideas multimodal SCI.
Язык: Английский
Процитировано
0
Fluids and Barriers of the CNS, Год журнала: 2025, Номер 22(1)
Опубликована: Апрель 2, 2025
Emerging evidence suggests that chronic stress compromises blood‒brain barrier (BBB) integrity by disrupting brain microvascular endothelial cells (BMECs), contributing to the development of cognitive impairments. Thus, targeting BBB is expected be a promising treatment strategy. The biological function rutin has been investigated in neurological disorders; however, its regulatory role stress-induced damage and decline underlying mechanisms remain elusive. In unpredictable mild (CUMS) mouse model, fluorescent dye assay behavioral tests, including novel object recognition test Morris water maze, were performed evaluate protective effects on cognition. BMEC also hCMEC/D3 (a human cell line) vitro. Furthermore, molecular which restores endothelium dysfunction explored via RNA-seq, quantitative real-time PCR, western blotting, immunofluorescence chromatin immunoprecipitation. Finally, biotinylated tumor necrosis factor-α (TNF-α) was employed influence ability circulating TNF-α cross BBB. We identified attenuated hyperpermeability impairment caused 8-week CUMS procedure. Moreover, promoted proliferation, migration angiogenesis BMECs, cellular monolayer through positively regulating expression genes involved. impeded histone deacetylase 1 (HDAC1) recruitment stabilized H3K27ac increase Claudin-5 protein levels. Ultimately, normalization hippocampal HDAC1‒Claudin-5 axis blocked infiltration into parenchyma alleviated neuroinflammation. This work establishes integrity, reveals potential drug candidate for curing deficits.
Язык: Английский
Процитировано
0
Chemico-Biological Interactions, Год журнала: 2024, Номер 400, С. 111159 - 111159
Опубликована: Июль 25, 2024
The activation and polarization of astrocytes are involved in neuroinflammation brain functional rehabilitation after ischemic stroke. Our previous studies display the neuroprotective effect genistein-3'-sodium sulfonate (GSS) acute phase cerebral ischemia-reperfusion injury (CI/RI). This study aimed to investigate function improvement GSS during recovery period CI/RI rats explore potential mechanism from perspective astrocyte polarization. transient middle artery occlusion (tMCAO) were treated with (1 mg/kg) continuously for 28 days. behavior tests measured assess neurological function. mRNA protein expression affected cortex detected on day 29 tMCAO. results demonstrated that treatment significantly improved spatial temporal gait parameters Catwalk test, prolonged time stick increased rotation speed rotarod decreased find hidden platform target quadrant Morris water maze test. In addition, GFAP, GBP2, C3, IL-1β expressions Nos2A level decreased, while Nrf2, BDNF, IL-10 Sphk1 Nef2l2 levels treatment. Interestingly, presented a strong binding affinity TLR4 suppressed NF-κB signaling. conclusion, can promote by inhibiting A1 phenotype, enhancing A2 phenotype via inactivating TLR4/NF-κB signaling, which provide candidate compound clinical therapy
Язык: Английский
Процитировано
3
Journal of Ethnopharmacology, Год журнала: 2024, Номер 336, С. 118718 - 118718
Опубликована: Авг. 23, 2024
Язык: Английский
Процитировано
3