The effect of alcohol, tobacco, and other drug use on vaccine acceptance, uptake, and adherence: a systematic review DOI
Eva Maria Havelka,

Jenna E. Sanfilippo,

Paul Juneau

и другие.

Alcohol and Alcoholism, Год журнала: 2024, Номер 59(6)

Опубликована: Сен. 21, 2024

Abstract Background Vaccine hesitancy is increasingly recognized as a health challenge affecting populations worldwide. Given the biological vulnerabilities and structural barriers people who use substances and/or have behavioral addictions face, this systematic review aims to evaluate whether subpopulation less prone adhere vaccination recommendations. Methods Electronic searches of published original research were conducted in PubMed, EMBASE, Scopus, PsycINFO from database inception December 2022. Our strategy encompassed retrievals regardless languages date publication. Animal studies, abstracts without full manuscript, studies which considered lower robustness scientific evidence excluded. Outcomes measured vaccine acceptance, uptake, adherence. Results interpreted through narrative synthesis. The search yielded 103 encompassing data collected on 5 576 374 persons predominantly residents Europe (n = 39) North America 27). Tobacco use, substance for many found 91), was significantly associated with poorer uptake adherence influenza, COVID-19, human papillomavirus (HPV), maternal childhood vaccines. Peri-natal parental identified risk factor suboptimal vaccine-related outcomes concerning COVID-19 Finally, ‘using’, ‘abusing’, or ‘misusing’ drugs may be at decreased odds all various Conclusions Collectively, several groups statistically significant greater engagement among whom targeted measures could beneficial. Timely evidence, especially besides tobacco, lacking, warrants urgent attention.

Язык: Английский

Alcohol consumption and metabolic syndrome: Clinical and epidemiological impact on liver disease DOI Creative Commons
Fredrik Åberg, Christopher D. Byrne, Carlos J. Pirola

и другие.

Journal of Hepatology, Год журнала: 2022, Номер 78(1), С. 191 - 206

Опубликована: Сен. 5, 2022

Язык: Английский

Процитировано

149
Global Epidemiology of Alcohol-Related Liver Disease, Liver Cancer, and Alcohol Use Disorder, 2000–2021 DOI Creative Commons
Pojsakorn Danpanichkul, Luis Antonio Díaz, Kanokphong Suparan

и другие.

Clinical and Molecular Hepatology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Alcohol represents a leading burden of disease worldwide, including alcohol use disorder (AUD) and alcohol-related liver (ALD). We aim to assess the global AUD, ALD, alcohol-attributable primary cancer between 2000-2021. registered regional trends using data from Global Burden Disease 2021 Study, largest most up-to-date epidemiology database. estimated annual percent change (APC) its 95% confidence interval (CI) changes in age-standardized rates over time. In 2021, there were 111.12 million cases 3.02 132,030 cancer. Between 2000 was 14.66% increase 38.68% 94.12% prevalence. While prevalence rate for increased (APC: 0.59%, [CI] 0.52 0.67%) these years, it decreased ALD -0.71%, CI -0.75 -0.67%) AUD -0.90%, -0.94 -0.86%). There significant variation by region, socioeconomic development level, sex. During last years (2019-2021), prevalence, incidence, death greater extent females. Given high cancer, urgent measures are needed prevent them at both national levels.

Язык: Английский

Процитировано

5
Management of alcohol use disorder: a gastroenterology and hepatology-focused perspective DOI
Luis Antonio Díaz, Daniel König, Sabine Weber

и другие.

˜The œLancet. Gastroenterology & hepatology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

3
Management of alcohol use disorder in patients with chronic liver disease DOI Creative Commons
Jessica L. Mellinger, Anne C. Fernandez, Gerald Scott Winder

и другие.

Hepatology Communications, Год журнала: 2023, Номер 7(7)

Опубликована: Июнь 14, 2023

Alcohol use disorder (AUD) rates have risen dramatically in the United States, resulting increasing of alcohol-associated liver disease (ALD), but many patients struggle to access alcohol treatment. AUD treatment improves outcomes, including mortality, and represents most urgent means by which care can be improved for those with (including ALD others) AUD. involves 3 steps: detecting use, diagnosing AUD, directing Detecting involve questioning during clinical interview, standardized surveys, biomarkers. Identifying are interview-based processes that should ideally performed a trained addiction professional, nonaddiction clinicians surveys determine severity hazardous drinking. Referral formal made, especially where more severe is suspected or identified. Therapeutic modalities numerous include different forms one-on-one psychotherapy, such as motivational enhancement therapy cognitive behavior therapy, group community mutual aid societies (such Alcoholics Anonymous), inpatient treatment, relapse prevention medications. Finally, integrated approaches build strong relationships between professionals hepatologists medical providers caring crucial improving this population.

Язык: Английский

Процитировано

23
New insights into the molecular basis of alcohol abstinence and relapse in alcohol-associated liver disease DOI
Luis Antonio Díaz, Gerald Scott Winder, Lorenzo Leggio

и другие.

Hepatology, Год журнала: 2023, Номер unknown

Опубликована: Окт. 20, 2023

Alcohol use disorder remains a significant public health concern, affecting around 5% of adults worldwide. Novel pathways damage have been described during the last years, providing insight into mechanism injury due to alcohol misuse beyond direct effect ethanol byproducts on liver parenchyma and neurobehavioral mechanisms. Thus, gut-liver-brain axis immune system involvement could be therapeutic targets for disorder. In particular, changes in gut microbiota composition function, bile acid homeostasis, shown with consumption cessation. can also directly disrupt intestinal blood-brain barriers. Activation triggered by barrier dysfunction translocation bacteria, pathogen-associated molecular patterns (such as lipopolysaccharide), cytokines, damage-associated patterns. These factors, turn, promote brain inflammation progression fibrosis. Other involved mechanisms include oxidative stress, apoptosis, autophagy, release extracellular vesicles miRNA from hepatocytes. Potential (probiotics fecal transplantation), neuroinflammatory pathways, well neuroendocrine example, ghrelin (ghrelin receptor blockade), incretin mimetics (glucagon-like peptide-1 analogs), mineralocorticoid (spironolactone). addition, support psychological behavioral treatments is essential address multiple dimensions future, personalized approach considering these novel contribute significantly decreasing alcohol-associated burden disease.

Язык: Английский

Процитировано

18
Problematic alcohol use and its impact on liver disease quality of life in a multicenter study of patients with cirrhosis DOI Creative Commons
Jeremy W. Luk, Derek D. Satre, Ramsey Cheung

и другие.

Hepatology Communications, Год журнала: 2024, Номер 8(2)

Опубликована: Фев. 1, 2024

Management of cirrhosis is challenging and has been complicated by the COVID-19 pandemic due to decreased access care, increased psychological distress, alcohol misuse. Recently, The National Institute on Alcohol Abuse Alcoholism broadened definition recovery from use disorder include quality life (QoL) as an indicator recovery. This study examined associations alcohol-associated etiology problematic drinking with liver disease QoL (LDQoL).

Язык: Английский

Процитировано

7
The Rising Costs of Alcohol-Associated Liver Disease in the United States DOI
Jovan Julien, Turgay Ayer, Elliot B. Tapper

и другие.

The American Journal of Gastroenterology, Год журнала: 2023, Номер 119(2), С. 270 - 277

Опубликована: Июль 18, 2023

INTRODUCTION: Alcohol-associated liver disease (ALD) is rising in the United States because of an increase high-risk drinking, but population-level ALD cost unknown. Our aim was to project direct and indirect costs associated with US population through 2040. METHODS: We used a previously validated microsimulation model alcohol consumption parameters estimated from publicly available data sources, including National Epidemiologic Survey Alcohol Related Conditions-III, Center for Disease Control Prevention Wide-ranging Online Data Research, Bureau Labor Statistics, published studies informing impact on severity resident population. The simulated scenario included current projected ALD-associated costs. RESULTS: From 2022 2040, $880 billion, $355 billion healthcare-related costs, $525 lost labor economic consumption. annual $31 $66 (118% increase) Although female makes up 29% these 2022, by 2040 per annum basis, would be 43% total expenditure. DISCUSSION: Increased population, especially females, will cause steep rise burden States. These findings highlight need planners policymakers plan increased

Язык: Английский

Процитировано

12
Safety and compliance of long-term low-dose ondansetron in alcohol use disorder treatment. DOI Creative Commons
Giovanni Addolorato, Hannu Alho, Paula B. M. de Andrade

и другие.

European Journal of Internal Medicine, Год журнала: 2024, Номер 127, С. 43 - 49

Опубликована: Март 23, 2024

Язык: Английский

Процитировано

4
GSDMD induces hepatocyte pyroptosis to trigger alcoholic hepatitis through modulating mitochondrial dysfunction DOI Creative Commons
Yandi Xie, Zilong Wang,

Guangjun Song

и другие.

Cell Division, Год журнала: 2024, Номер 19(1)

Опубликована: Март 26, 2024

Abstract Background Mechanisms and consequences of Gasdermin D (GSDMD) activation in alcoholic hepatitis (AH) are unclear. In the present study, we investigated whether GSDMD induces hepatocyte pyroptosis by regulating mitochondrial dysfunction AH. Results Liver damage AH mice was assessed HE staining, serum levels AST, ALT, TC, TG. The IL-1β, IL-18, LDH, inflammasome-associated proteins death were to determine pyroptosis. Mitochondrial through various parameters including DNA (mtDNA) levels, ROS generation, membrane potential, ATP contents, function-related morphological changes mitochondria. induced gasdermin activation, leading increased protein expression N-terminal (GSDMD-N), NLRP3, Caspase 11 liver tissues. Downregulation alleviated alcohol-induced Alcohol also causes hepatocytes AH, which improved inhibiting GSDMD. Furthermore, enhancing function suppressed Further, knockdown or dynamin-related 1 (Drp1) AH-induced injury, accompanied a decrease Conclusion modulating during inflammation injury. These findings may pave way develop new therapeutic treatments for

Язык: Английский

Процитировано

4
Treatment engagement in comorbid alcohol use disorder and alcohol‐related liver disease: A qualitative exploration of barriers and facilitators with service users DOI Creative Commons
Sofia Hemrage, Stephen Parkin, Nicola J. Kalk

и другие.

Alcohol Clinical and Experimental Research, Год журнала: 2024, Номер 48(10), С. 1965 - 1978

Опубликована: Авг. 27, 2024

Effective interventions to improve patient outcomes in comorbid alcohol use disorder (AUD) and alcohol-related liver disease (ARLD) remain a clinical unmet need. While the choice of abstinence is cornerstone for prevention progression mortality, evidence suggests suboptimal engagement with treatment supporting recovery. This qualitative investigation aims understand barriers facilitators as experienced by this population applying multidimensional adherence model proposed World Health Organization.

Язык: Английский

Процитировано

4