Time cells in the retrosplenial cortex
Hippocampus,
Год журнала:
2024,
Номер
34(11), С. 598 - 607
Опубликована: Авг. 29, 2024
The
retrosplenial
cortex
(RSC)
is
a
key
component
of
the
brain's
memory
systems,
with
anatomical
connections
to
hippocampus,
anterior
thalamus,
and
entorhinal
cortex.
This
circuit
has
been
implicated
in
episodic
many
these
structures
have
shown
encode
temporal
information,
which
critical
for
memory.
For
example,
hippocampal
time
cells
reliably
fire
during
specific
segments
delay
period.
Although
RSC
lesions
are
known
disrupt
memory,
not
observed
there.
In
this
study,
we
reanalyzed
archival
neuronal
firing
data
intertrial
period
from
two
previous
experiments
involving
different
behavioral
tasks,
blocked
alternation
task
cued
T-maze
task.
task,
rats
were
required
approach
east
or
west
arm
plus
maze
reward
blocks
trials.
Because
locations
cued,
rat
had
remember
goal
location
each
trial.
was
explicitly
light
simply
reward,
so
there
no
requirement
hold
delay.
Time
prevalent
most
clearly
differentiated
We
also
found
that
neurons
could
exhibit
off-response
fields,
periods
inhibited
firing.
T-maze,
but
they
less
did
differentiate
left
right
trials
as
well
suggesting
sensitive
demands
These
results
suggest
coding
prominent
feature
patterns,
consistent
an
role
Язык: Английский
Visual objects refine head direction coding
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 22, 2024
Abstract
Animals
use
visual
objects
to
guide
navigation-related
behaviors,
from
hunting
prey,
escaping
predators,
exploring
the
world.
However,
little
is
known
about
where
are
encoded
in
mouse
brain
or
how
impact
processing
within
spatial
navigation
system.
Using
functional
ultrasound
(fUS)
imaging
mice,
we
conducted
a
brain-wide
screen
and
identified
areas
that
were
preferentially
activated
by
images
of
compared
scrambled
versions
same
stimuli.
While
cortical
did
not
show
significant
preference,
regions
associated
with
objects.
Electrophysiological
recordings
postsubiculum,
primary
area
head
direction
(HD)
system,
further
confirmed
preference
for
objects,
which
was
present
both
HD
cells
fast-spiking
interneurons.
Finally,
found
dynamically
modulate
cells,
selectively
increasing
firing
rates
aligned
landmark’s
direction,
while
suppressing
activity
coding
other
directions.
These
results
reveal
refine
population-level
direction.
Язык: Английский
The Retrosplenial Cortical Role in Delayed Spatial Alternation.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 22, 2024
Abstract
The
retrosplenial
cortex
(RSC)
plays
an
important
role
in
spatial
cognition.
RSC
neurons
exhibit
a
variety
of
firing
patterns
and
lesion
studies
have
found
that
the
is
necessary
for
working
memory
tasks.
However,
little
known
about
how
might
encode
during
delay
period.
In
present
study,
we
trained
control
rats
with
excitotoxic
lesions
on
alternation
task
varying
durations
separate
group
rats,
recorded
neuronal
activity
as
performed
task.
We
significantly
impaired
performance,
particularly
at
longest
duration.
also
exhibited
reliably
different
throughout
periods
preceding
left
right
trials,
consistent
signal.
These
differential
were
absent
errors.
many
large
spike
rate
leading
up
to
start
trial.
Many
these
trial
responses
differentiated
suggesting
they
could
play
priming
‘go
left’
or
right’
behavioral
responses.
Our
results
suggest
represent
critical
information
underlies
memory.
Язык: Английский
The retrosplenial cortical role in delayed spatial alternation
Neurobiology of Learning and Memory,
Год журнала:
2024,
Номер
216, С. 108005 - 108005
Опубликована: Ноя. 13, 2024
Язык: Английский
Retrosplenial cortex encodes both local and global space in connected environments
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 22, 2024
In
everyday
life,
mammals
have
to
find
their
way
between
interconnected
spaces.
How
the
brain
processes
spatial
information
in
these
complex
environments
is
a
crucial
question
for
understanding
how
we
navigate.
Theoretical
frameworks
proposed
that
presents
simultaneous
activities
are
either
maintained
connected
spaces
(global
reference
frame)
or
distinguished
each
space
(local
frames).
The
different
head
direction
signals
discovered
retrosplenial
cortex
(RSC)
suggest
this
area
supports
both
local
and
global
activity.
We
tested
hypothesis
by
recording
RSC
neurons
consisting
of
2
4
rooms
identical
different.
observed
two
types
activity
simultaneously:
one
showing
opposite
orthogonal
directional
thus
anchored
frames,
maintaining
stable
across
frame.
also
found
other
show
pattern
repeats
oppositely
orthogonally
respectively.
contrast,
hippocampal
place
cells
never
shows
patterns,
but
rather
remapping
translational
repeated
Overall,
results
only
has
neuronal
necessary
form
representation
environments.
Язык: Английский