Time cells in the retrosplenial cortex

Hippocampus, Journal Year: 2024, Volume and Issue: 34(11), P. 598 - 607

Published: Aug. 29, 2024

The retrosplenial cortex (RSC) is a key component of the brain's memory systems, with anatomical connections to hippocampus, anterior thalamus, and entorhinal cortex. This circuit has been implicated in episodic many these structures have shown encode temporal information, which critical for memory. For example, hippocampal time cells reliably fire during specific segments delay period. Although RSC lesions are known disrupt memory, not observed there. In this study, we reanalyzed archival neuronal firing data intertrial period from two previous experiments involving different behavioral tasks, blocked alternation task cued T-maze task. task, rats were required approach east or west arm plus maze reward blocks trials. Because locations cued, rat had remember goal location each trial. was explicitly light simply reward, so there no requirement hold delay. Time prevalent most clearly differentiated We also found that neurons could exhibit off-response fields, periods inhibited firing. T-maze, but they less did differentiate left right trials as well suggesting sensitive demands These results suggest coding prominent feature patterns, consistent an role

Language: Английский

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Visual objects refine head direction coding

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Animals use visual objects to guide navigation-related behaviors, from hunting prey, escaping predators, exploring the world. However, little is known about where are encoded in mouse brain or how impact processing within spatial navigation system. Using functional ultrasound (fUS) imaging mice, we conducted a brain-wide screen and identified areas that were preferentially activated by images of compared scrambled versions same stimuli. While cortical did not show significant preference, regions associated with objects. Electrophysiological recordings postsubiculum, primary area head direction (HD) system, further confirmed preference for objects, which was present both HD cells fast-spiking interneurons. Finally, found dynamically modulate cells, selectively increasing firing rates aligned landmark’s direction, while suppressing activity coding other directions. These results reveal refine population-level direction.

Language: Английский

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The Retrosplenial Cortical Role in Delayed Spatial Alternation.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 22, 2024

Abstract The retrosplenial cortex (RSC) plays an important role in spatial cognition. RSC neurons exhibit a variety of firing patterns and lesion studies have found that the is necessary for working memory tasks. However, little known about how might encode during delay period. In present study, we trained control rats with excitotoxic lesions on alternation task varying durations separate group rats, recorded neuronal activity as performed task. We significantly impaired performance, particularly at longest duration. also exhibited reliably different throughout periods preceding left right trials, consistent signal. These differential were absent errors. many large spike rate leading up to start trial. Many these trial responses differentiated suggesting they could play priming ‘go left’ or right’ behavioral responses. Our results suggest represent critical information underlies memory.

Language: Английский

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Retrosplenial cortex encodes both local and global space in connected environments

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 22, 2024

In everyday life, mammals have to find their way between interconnected spaces. How the brain processes spatial information in these complex environments is a crucial question for understanding how we navigate. Theoretical frameworks proposed that presents simultaneous activities are either maintained connected spaces (global reference frame) or distinguished each space (local frames). The different head direction signals discovered retrosplenial cortex (RSC) suggest this area supports both local and global activity. We tested hypothesis by recording RSC neurons consisting of 2 4 rooms identical different. observed two types activity simultaneously: one showing opposite orthogonal directional thus anchored frames, maintaining stable across frame. also found other show pattern repeats oppositely orthogonally respectively. contrast, hippocampal place cells never shows patterns, but rather remapping translational repeated Overall, results only has neuronal necessary form representation environments.

Language: Английский

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The retrosplenial cortical role in delayed spatial alternation

Neurobiology of Learning and Memory, Journal Year: 2024, Volume and Issue: 216, P. 108005 - 108005

Published: Nov. 13, 2024

Language: Английский

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