Biomedicines,
Год журнала:
2024,
Номер
12(6), С. 1360 - 1360
Опубликована: Июнь 19, 2024
MicroRNAs
(miRNAs)
are
short
noncoding
RNA
sequences
that
regulate
gene
expression
at
the
post-transcriptional
level.
They
involved
in
regulation
of
multiple
pathways,
related
to
both
physiological
and
pathological
conditions,
including
autoimmune
diseases,
such
as
Systemic
Sclerosis
(SSc).
Specifically,
SSc
is
recognized
a
complex
multifactorial
disease,
characterized
by
vascular
abnormalities,
immune
dysfunction,
progressive
fibrosis,
affecting
skin
internal
organs.
Among
predisposing
environmental
triggers,
evidence
supports
roles
oxidative
stress,
chemical
agents,
viral
infections,
mostly
those
sustained
beta-herpesviruses
HCMV
HHV-6.
Dysregulated
levels
miRNA
have
been
found
patients
compared
healthy
controls,
intra-
extracellular
levels,
providing
sort
signature
disease.
Notably,
HCMV/HHV-6
infections
were
shown
modulate
profile,
often
superposing
observed
SSc,
potentially
promoting
pathways
associated
with
development.
This
review
summarizes
main
data
regarding
alterations
highlighting
their
potential
prognostic
or
diagnostic
markers
for
impact
putative
etiological
agents
on
modulation.
Materials Today Chemistry,
Год журнала:
2024,
Номер
39, С. 102178 - 102178
Опубликована: Июль 1, 2024
Inflammatory
arthritis
is
a
growing
worldwide
concern,
afflicting
millions
of
individuals
and
leading
to
depreciating
quality
life,
significant
morbidity,
subsequent
healthcare
burden.
Conventional
therapies
for
inflammatory
often
hold
limitations,
including
systemic
cross-reactivities,
side
effects,
inadequate
management
inflammation.
Therefore,
"Smart"
stimuli-responsive
biomaterials
are
materialized
as
promising
theranostic
approaches
management.
These
designed
specific
external
internal
stimulation,
enabling
the
sustained
release
bioactive
therapeutic
agents
during
local
or
administration.
Stimuli-responsive
allow
precise
spatiotemporal
control
over
drug
release,
minimizing
exposure,
reducing
off-target
real-time
monitoring
pathological
conditions,
driving
potential
breakthrough
in
managing
arthritis.
Owing
this
prominence,
review
article
expounds
on
emerging
prospects
targeting
molecular
signatures
associated
with
intricately
elicit
minimal
no
contradictory
effects.
In
addition,
application
these
disease
progression
multi-stimuli-responsive
comprehended
show
progress
diagnosis
treatment.
This
"single-platted"
comprehensive
acquaintance
clinical-based
outcomes
navigates
microenvironment,
proposing
an
optimistic
avenue
personalized
effective
minimized
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
662, С. 124535 - 124535
Опубликована: Авг. 1, 2024
The
advancements
in
nanotechnology,
pharmaceutical
sciences,
and
healthcare
are
propelling
the
field
of
theranostics,
which
combines
therapy
diagnostics,
to
new
heights;
emphasizing
emergence
selenium
nanoparticles
(SeNPs)
as
versatile
theranostic
agents.
This
comprehensive
update
offers
a
holistic
perspective
on
recent
developments
synthesis
applications
SeNPs,
underscoring
their
growing
importance
nanotechnology
healthcare.
SeNPs
have
shown
significant
potential
multiple
domains,
including
antioxidant,
anti-inflammatory,
anticancer,
antimicrobial,
antidiabetic,
wound
healing,
cytoprotective
therapies.
review
highlights
adaptability
biocompatibility
crucial
for
advanced
disease
detection,
monitoring,
personalized
treatment.
Special
emphasis
is
placed
green
techniques,
eco-friendly
cost-effective
benefits
biosensing,
imaging
therapeutic
applications.
Additionally,
appraisal
scrutinizes
progressive
trends
smart
stimuli-responsive
conferring
role
innovative
solutions
management
diagnostics.
Despite
promising
prophylactic
potential,
also
present
several
challenges,
particularly
regarding
toxicity
concerns.
These
challenges
implications
clinical
translation
thoroughly
explored,
providing
balanced
view
current
state
prospects
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2789 - 2789
Опубликована: Фев. 28, 2024
The
advent
of
biologic
drugs
has
revolutionized
the
treatment
Inflammatory
Bowel
Disease,
increasing
rates
response
and
mucosal
healing
in
comparison
to
conventional
therapies
by
allowing
corticosteroid-refractory
cases
reducing
corticosteroid-related
side
effects.
However,
(anti-TNFα
inhibitors,
anti-α4β7
integrin
anti-IL12/23)
are
still
burdened
that
hover
around
40%
(in
biologic-naïve
patients)
or
lower
(for
biologic-experienced
patients).
Moreover,
knowledge
mechanisms
underlying
drug
resistance
loss
is
scarce.
Several
cellular
molecular
determinants
implied
therapeutic
failure;
genetic
predispositions,
form
single
nucleotide
polymorphisms
sequence
cytokines
Human
Leukocyte
Antigen,
an
altered
expression
other
molecules
involved
inflammation
cascade,
play
most
important
role.
Accessory
include
gut
microbiota
dysregulation.
In
this
narrative
review
current
recent
literature,
we
shed
light
on
mentioned
failure
order
pave
way
for
a
more
personalized
approach
could
help
avoid
unnecessary
treatments
toxicities.
Immunity Inflammation and Disease,
Год журнала:
2023,
Номер
11(12)
Опубликована: Дек. 1, 2023
Abstract
Background
Autoimmune
diseases
(AD)
are
severe
pathophysiological
ailments
that
stimulated
by
an
exaggerated
immunogenic
response
towards
self‐antigens,
which
can
cause
systemic
or
site‐specific
organ
damage.
An
array
of
complex
genetic
and
epigenetic
facets
majorly
contributes
to
the
progression
AD,
thus
providing
significant
insight
into
regulatory
mechanism
microRNA
(miRNA).
miRNAs
short,
non‐coding
RNAs
have
been
identified
as
essential
contributors
post‐transcriptional
regulation
host
genome
expression
crucial
regulators
a
myriad
biological
processes
such
immune
homeostasis,
T
helper
cell
differentiation,
central
peripheral
tolerance,
development.
Aims
This
article
tends
deliberate
conceptualize
brief
pathogenesis
pertinent
well
miRNA
networks
affecting
five
different
ADs
namely
rheumatoid
arthritis
(RA),
type
1
diabetes,
multiple
sclerosis
(MS),
lupus
erythematosus
(SLE)
inflammatory
bowel
disorder
(IBD)
thereby
novel
miRNA‐based
theranostic
interventions.
Results
&
Discussion
Pertaining
differential
attributed
in
target
tissues
cellular
bodies
innate
adaptive
immunity,
paradigm
scientific
expeditions
suggests
optimistic
correlation
between
dysfunction
alterations.
Conclusion
Therefore,
it
is
not
astonishing
dysregulations
patterns
now
recognized
wide
spectrum
disorders,
establishing
themselves
potential
biomarkers
therapeutic
targets.
Owing
its
potencies,
targets
widely
utilized
development
biosensors
other
molecules
originating
from
same.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8420 - 8420
Опубликована: Авг. 1, 2024
Inflammatory
bowel
disease
(IBD)
represents
heterogeneous
and
relapsing
intestinal
conditions
with
a
severe
impact
on
the
quality
of
life
individuals
continuously
increasing
prevalence.
In
recent
years,
development
sequencing
technology
has
provided
new
means
exploring
complex
pathogenesis
IBD.
An
ideal
solution
is
represented
by
approach
precision
medicine
that
investigates
multiple
cellular
molecular
interactions,
which
are
tools
perform
holistic,
systematic,
impartial
analysis
genomic,
transcriptomic,
proteomic,
metabolomic,
microbiomics
sets.
Hence,
it
led
to
orientation
current
research
towards
identification
biomarkers
could
be
successfully
used
in
management
IBD
patients.
Multi-omics
explores
dimension
variation
characteristics
these
diseases,
offering
advantage
understanding
mechanisms
affect
homeostasis
for
much
better
prediction
choice
treatment.
This
review
focuses
progress
made
field
prognostic
predictive
biomarkers,
highlighting
limitations,
challenges,
also
opportunities
associated
application
genomics
epigenomics
technologies
clinical
practice.
