Biomedicines,
Год журнала:
2024,
Номер
12(6), С. 1360 - 1360
Опубликована: Июнь 19, 2024
MicroRNAs
(miRNAs)
are
short
noncoding
RNA
sequences
that
regulate
gene
expression
at
the
post-transcriptional
level.
They
involved
in
regulation
of
multiple
pathways,
related
to
both
physiological
and
pathological
conditions,
including
autoimmune
diseases,
such
as
Systemic
Sclerosis
(SSc).
Specifically,
SSc
is
recognized
a
complex
multifactorial
disease,
characterized
by
vascular
abnormalities,
immune
dysfunction,
progressive
fibrosis,
affecting
skin
internal
organs.
Among
predisposing
environmental
triggers,
evidence
supports
roles
oxidative
stress,
chemical
agents,
viral
infections,
mostly
those
sustained
beta-herpesviruses
HCMV
HHV-6.
Dysregulated
levels
miRNA
have
been
found
patients
compared
healthy
controls,
intra-
extracellular
levels,
providing
sort
signature
disease.
Notably,
HCMV/HHV-6
infections
were
shown
modulate
profile,
often
superposing
observed
SSc,
potentially
promoting
pathways
associated
with
development.
This
review
summarizes
main
data
regarding
alterations
highlighting
their
potential
prognostic
or
diagnostic
markers
for
impact
putative
etiological
agents
on
modulation.
Gene,
Год журнала:
2024,
Номер
933, С. 149011 - 149011
Опубликована: Окт. 18, 2024
Systemic
lupus
erythematosus
(SLE)
is
a
complex
autoimmune
disease
marked
by
abnormal
B-cell
proliferation
and
increased
autoantibodies.
miRNAs
play
crucial
role
in
regulating
dysfunction
SLE
pathology.
influence
DNA
methylation,
activation,
gene
expression,
contributing
to
pathogenesis.
impact
B
cells
through
key
processes
like
proliferation,
differentiation,
tolerance,
apoptosis.
also
exacerbate
inflammation
immune
responses
modulating
Interleukin
4
(IL-4),
IL-6,
interferon
cytokines.
Autophagy,
degradation
mechanism,
regulated
specific
that
This
article
explores
the
of
multiple
development,
survival,
responses,
influencing
miR-23a,
miR-17
∼
92
family,
miR-125b/miR-221
affect
development
transcription
factors,
signaling
pathways,
cell
cycle
genes.
such
as
miR-181a-5p
miR-23a-5p
are
differentially
across
developmental
stages,
emphasizing
their
regulatory
roles
biology.
synthesizes
miRNA-B
interactions
offer
new
strategies
directions
for
diagnosis
treatment.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3647 - 3647
Опубликована: Март 25, 2024
Epigenetic
mechanisms
inducing
phenotypic
changes
without
altering
the
DNA
genome
are
increasingly
recognized
as
key
factors
modulating
gene
expression
and,
consequently,
cell
functions
[...]
Biomedicines,
Год журнала:
2024,
Номер
12(6), С. 1360 - 1360
Опубликована: Июнь 19, 2024
MicroRNAs
(miRNAs)
are
short
noncoding
RNA
sequences
that
regulate
gene
expression
at
the
post-transcriptional
level.
They
involved
in
regulation
of
multiple
pathways,
related
to
both
physiological
and
pathological
conditions,
including
autoimmune
diseases,
such
as
Systemic
Sclerosis
(SSc).
Specifically,
SSc
is
recognized
a
complex
multifactorial
disease,
characterized
by
vascular
abnormalities,
immune
dysfunction,
progressive
fibrosis,
affecting
skin
internal
organs.
Among
predisposing
environmental
triggers,
evidence
supports
roles
oxidative
stress,
chemical
agents,
viral
infections,
mostly
those
sustained
beta-herpesviruses
HCMV
HHV-6.
Dysregulated
levels
miRNA
have
been
found
patients
compared
healthy
controls,
intra-
extracellular
levels,
providing
sort
signature
disease.
Notably,
HCMV/HHV-6
infections
were
shown
modulate
profile,
often
superposing
observed
SSc,
potentially
promoting
pathways
associated
with
development.
This
review
summarizes
main
data
regarding
alterations
highlighting
their
potential
prognostic
or
diagnostic
markers
for
impact
putative
etiological
agents
on
modulation.
