The molecular mechanism of berberine affecting psoriasis skin inflammation by regulating keratinocyte pyroptosis via the p38 MAPK/NF-κB pathway DOI
Wenfang Chen, Lingzhi Ge, Chao Zhang

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 4, 2024

Язык: Английский

Immunoregulatory effects of traditional Chinese medicine and its ingredients on psoriasis DOI
Wei Feng, Huazhen Liu, Chun-Ling Liang

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 159, С. 114896 - 114896

Опубликована: Май 22, 2025

Язык: Английский

Процитировано

1
Knockdown of GSDMD inhibits pyroptosis in psoriasis by blocking the NOD-like receptor signaling pathway DOI

S. Lai,

Huaqing Chen, Xiaojuan Ji

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 147, С. 114036 - 114036

Опубликована: Янв. 7, 2025

Язык: Английский

Процитировано

0
Paris saponin VII attenuates psoriasiform inflammation by regulating STAT3/NFκB signaling pathway and Caspase-1-induced pyroptosis DOI Creative Commons
Xiangnan Zhou,

Jingyuan Ning,

Doudou Wu

и другие.

Molecular Medicine, Год журнала: 2025, Номер 31(1)

Опубликована: Май 22, 2025

Abstract Psoriasis is a significant global health challenge due to limited treatment efficacy. Paris saponin VII (PSVII) shows anti-inflammatory and anti-proliferative potential but its role in psoriasis unclear. In this study, PSVII was identified from library of natural compounds as therapeutic candidate for psoriasis. murine model, reduced skin lesion severity, epidermal thickness, inflammatory factor expression, preliminaryly indicating properties. vitro, inhibited HaCaT cell hyperproliferation, regulated the cycle, induced apoptosis, modulated reactive oxygen species (ROS). Bioinformatics analyses suggested that signal transducer activator transcription 3 (STAT3), cysteine aspartate specific protease 1 (Caspase-1), process pyroptosis are likely targets mechanisms action. could reduce mortality psoriatic cells lowered expression levels NLR Family Pyrin Domain Containing (NLRP3), Caspase-1, Gasdermin D (GSDMD), Interleukins (IL)-18, IL-1β, underscoring modulating within these cells. Mechanistically, may suppress STAT3/nuclear kappa B (NFκB) signaling pathway. Consequently, plays management. modulate pyroptotic death by targeting STAT3/NFκB cascade, leading effects, thereby ameliorating symptoms.

Язык: Английский

Процитировано

0
Multi-omics analysis of outer membrane vesicles from P. goldsteinii in a psoriasis mouse model DOI
Anqi Du, Jiayu Chen, Zhaoxiang Xie

и другие.

Life Sciences, Год журнала: 2025, Номер unknown, С. 123776 - 123776

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
The molecular mechanism of berberine affecting psoriasis skin inflammation by regulating keratinocyte pyroptosis via the p38 MAPK/NF-κB pathway DOI
Wenfang Chen, Lingzhi Ge, Chao Zhang

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 4, 2024

Язык: Английский

Процитировано

1