Topics in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 37 - 53
Опубликована: Янв. 1, 2024
Язык: Английский
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(6), С. 4074 - 4084
Опубликована: Фев. 23, 2024
Herein, an oxidant- and metal-free electrochemical selenylation reaction of chalcones with diselenides for the synthesis 3-selenylazaflavanones 3-selenylflavanones at room temperature was reported. The method proceeded under mild conditions, exhibited a broad substrate scope, provided selenylated products in moderate to excellent yields high regio- stereoselectivity. could also be readily scaled up efficiency. Detailed mechanistic studies through control experiments disclosed that selenium-based radical might participate this transformation.
Язык: Английский
Процитировано
10
Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(30), С. 6198 - 6204
Опубликована: Янв. 1, 2024
Reported herein is a visible-light induced selenocyclization of 2-ethynylanilines under ambient conditions, with simple FeBr 3 as dual-functional catalyst.
Язык: Английский
Процитировано
7
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(12), С. 8632 - 8640
Опубликована: Июнь 6, 2024
Herein, we disclosed a highly efficient pathway toward 3-selenylated chromone derivatives via electrocatalytic cascade selenylation/cyclization/deamination of 2-hydroxyaryl enaminones with diselenides. This method showed mild conditions, easy operation, wide substrate scope, and good functional group tolerance. Furthermore, this electrosynthesis strategy was amendable to scale-up the reaction. Additionally, preliminary experiments revealed that reaction probably proceeded cation instead radical pathway.
Язык: Английский
Процитировано
6
SynOpen, Год журнала: 2023, Номер 07(04), С. 511 - 520
Опубликована: Окт. 1, 2023
Abstract Electrochemical synthesis, due to its environmentally benign, sustainable, and practical nature, has become an appealing powerful substitute for traditional methods oxidizing reducing organic compounds. Thus, numerous valuable changes have been established in the field of synthesis through utilization electrochemistry. Among these electrochemical transformations, formation C–Se bonds stands out as exceptionally noteworthy reaction type. In this graphical review, we present a succinct summary progress utilizing strategies synthesizing organoselenium
Язык: Английский
Процитировано
12
Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
A green, efficient, and environmentally friendly electrochemical strategy was developed for synthesizing a series of selenoheterocyclic compounds. The antitumor activities these compounds were evaluated, revealing that 4o, 5n, 5o demonstrated remarkable efficacy. These effectively inhibited lung cancer by inducing cell apoptosis, causing DNA damage, suppressing the progression epithelial-mesenchymal transition. Notably, compound identified as first inhibitor DEAD-box helicase 10 (DDX10). An in vivo xenograft assay further confirmed therapeutic potential 5o, demonstrating tumor growth inhibition rates 60%, 78%, 88% at doses 5 mg/kg, 20 respectively. This study highlights promising chemotherapeutic agent effective treatment cancer.
Язык: Английский
Процитировано
0
Tetrahedron, Год журнала: 2023, Номер 148, С. 133667 - 133667
Опубликована: Сен. 26, 2023
Язык: Английский
Процитировано
5
Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown
Опубликована: Окт. 19, 2024
Abstract Electrosynthesis of selenylated‐oxazolone derivatives via cascade selenylation/cyclization ynamides was disclosed. A series diaryl diselenides, dialkyl and heteroaryl‐substituted tolerated in this protocol delivered 4‐selenyloxazolones 28–83% yields. The scale‐up reaction the oxidation performed to showcase practicability method. Furthermore, mechanistic experiments indicated that a cationic pathway instead radical probably involved.
Язык: Английский
Процитировано
1
Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown
Опубликована: Июль 29, 2024
Abstract Alkynes are simple yet important organic feedstocks. The selenylation of alkynes is able to produce complex selenium‐containing compounds in a facile way. Although there some reviews about the alkynes, most them focus on one specific reaction or what types products that can be obtained. There lack attention given various uses different selenium reagents and their mechanisms. This review mainly focuses recent advances (2013–2023) based diverse reagents. Mechanisms how added work will discussed. Different types, including difunctionalization, Se‐annulation, spiro‐cyclization, C−Se coupling, click recorded this review. regioselectivity achieved through mechanisms, radicals, seleniraniums electrophilic cyclization. We hope it do help for future research area.
Язык: Английский
Процитировано
1
Chemical Communications, Год журнала: 2024, Номер 60(65), С. 8516 - 8525
Опубликована: Янв. 1, 2024
This review summarizes recent advances in the electrochemically enabled construction of indoles from non-indole-based precursors and their underlying mechanisms.
Язык: Английский
Процитировано
0
Topics in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 37 - 53
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0