Chemical Communications, Journal Year: 2024, Volume and Issue: 60(65), P. 8516 - 8525
Published: Jan. 1, 2024
This review summarizes recent advances in the electrochemically enabled construction of indoles from non-indole-based precursors and their underlying mechanisms.
Language: Английский
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(6), P. 4074 - 4084
Published: Feb. 23, 2024
Herein, an oxidant- and metal-free electrochemical selenylation reaction of chalcones with diselenides for the synthesis 3-selenylazaflavanones 3-selenylflavanones at room temperature was reported. The method proceeded under mild conditions, exhibited a broad substrate scope, provided selenylated products in moderate to excellent yields high regio- stereoselectivity. could also be readily scaled up efficiency. Detailed mechanistic studies through control experiments disclosed that selenium-based radical might participate this transformation.
Language: Английский
Citations
10
Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(30), P. 6198 - 6204
Published: Jan. 1, 2024
Reported herein is a visible-light induced selenocyclization of 2-ethynylanilines under ambient conditions, with simple FeBr 3 as dual-functional catalyst.
Language: Английский
Citations
7
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(12), P. 8632 - 8640
Published: June 6, 2024
Herein, we disclosed a highly efficient pathway toward 3-selenylated chromone derivatives via electrocatalytic cascade selenylation/cyclization/deamination of 2-hydroxyaryl enaminones with diselenides. This method showed mild conditions, easy operation, wide substrate scope, and good functional group tolerance. Furthermore, this electrosynthesis strategy was amendable to scale-up the reaction. Additionally, preliminary experiments revealed that reaction probably proceeded cation instead radical pathway.
Language: Английский
Citations
6
SynOpen, Journal Year: 2023, Volume and Issue: 07(04), P. 511 - 520
Published: Oct. 1, 2023
Abstract Electrochemical synthesis, due to its environmentally benign, sustainable, and practical nature, has become an appealing powerful substitute for traditional methods oxidizing reducing organic compounds. Thus, numerous valuable changes have been established in the field of synthesis through utilization electrochemistry. Among these electrochemical transformations, formation C–Se bonds stands out as exceptionally noteworthy reaction type. In this graphical review, we present a succinct summary progress utilizing strategies synthesizing organoselenium
Language: Английский
Citations
12
Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
A green, efficient, and environmentally friendly electrochemical strategy was developed for synthesizing a series of selenoheterocyclic compounds. The antitumor activities these compounds were evaluated, revealing that 4o, 5n, 5o demonstrated remarkable efficacy. These effectively inhibited lung cancer by inducing cell apoptosis, causing DNA damage, suppressing the progression epithelial-mesenchymal transition. Notably, compound identified as first inhibitor DEAD-box helicase 10 (DDX10). An in vivo xenograft assay further confirmed therapeutic potential 5o, demonstrating tumor growth inhibition rates 60%, 78%, 88% at doses 5 mg/kg, 20 respectively. This study highlights promising chemotherapeutic agent effective treatment cancer.
Language: Английский
Citations
0
Tetrahedron, Journal Year: 2023, Volume and Issue: 148, P. 133667 - 133667
Published: Sept. 26, 2023
Language: Английский
Citations
5
Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 19, 2024
Abstract Electrosynthesis of selenylated‐oxazolone derivatives via cascade selenylation/cyclization ynamides was disclosed. A series diaryl diselenides, dialkyl and heteroaryl‐substituted tolerated in this protocol delivered 4‐selenyloxazolones 28–83% yields. The scale‐up reaction the oxidation performed to showcase practicability method. Furthermore, mechanistic experiments indicated that a cationic pathway instead radical probably involved.
Language: Английский
Citations
1
Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown
Published: July 29, 2024
Abstract Alkynes are simple yet important organic feedstocks. The selenylation of alkynes is able to produce complex selenium‐containing compounds in a facile way. Although there some reviews about the alkynes, most them focus on one specific reaction or what types products that can be obtained. There lack attention given various uses different selenium reagents and their mechanisms. This review mainly focuses recent advances (2013–2023) based diverse reagents. Mechanisms how added work will discussed. Different types, including difunctionalization, Se‐annulation, spiro‐cyclization, C−Se coupling, click recorded this review. regioselectivity achieved through mechanisms, radicals, seleniraniums electrophilic cyclization. We hope it do help for future research area.
Language: Английский
Citations
1
Topics in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 37 - 53
Published: Jan. 1, 2024
Language: Английский
Citations
0
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(65), P. 8516 - 8525
Published: Jan. 1, 2024
This review summarizes recent advances in the electrochemically enabled construction of indoles from non-indole-based precursors and their underlying mechanisms.
Language: Английский
Citations
0