Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials
ACS Applied Bio Materials,
Год журнала:
2023,
Номер
6(9), С. 3600 - 3616
Опубликована: Авг. 24, 2023
Contact
lenses
are
one
of
the
most
successful
applications
biomaterials.
The
chemical
structure
polymers
used
in
contact
plays
an
important
role
determining
function
lenses.
Different
types
have
been
developed
based
on
polymers.
When
designing
lenses,
materials
scientists
consider
factors
such
as
mechanical
properties,
processing
optical
histocompatibility,
and
antifouling
to
ensure
long-term
wear
with
minimal
discomfort.
Advances
lens
addressed
traditional
issues
oxygen
permeability
biocompatibility,
improving
overall
comfort,
duration
use.
For
example,
silicone
hydrogel
high
were
extend
In
addition,
controlling
surface
properties
direct
cornea
tissue
through
polymer
modification
mimics
morphology
corneal
while
maintaining
essential
lens,
a
significant
improvement
for
use
reuse
This
review
presents
material
science
elements
required
advanced
future
summarizes
methods
achieving
these
goals.
Язык: Английский
Prosthetic heart valves for transcatheter aortic valve replacement
BMEMat,
Год журнала:
2023,
Номер
1(2)
Опубликована: Май 26, 2023
Abstract
Transcatheter
aortic
valve
replacement
(TAVR)
has
the
advantages
of
less
trauma
and
faster
postoperative
recovery,
which
brought
possibility
to
elderly
patient
with
valvular
heart
disease
is
gradually
replacing
surgical
(SAVR).
The
interventional
used
in
TAVR
needs
be
compressed
transported
through
catheter
lesion
site,
can
still
recover
its
original
shape,
structure
performance.
This
process
requires
that
material
should
flexible,
rigid
mechanical
valves
SAVR
are
not
suitable.
Recently,
decellularized
biological
have
been
widely
clinical
practice,
but
their
poor
durability
causes
a
limitation
for
long‐term
implantation.
Therefore,
anti‐calcification
modification
design
new
polymeric
good
biostability
gained
considerable
attention.
review
summarizes
calcification
mechanism
research
progress
strategies.
Besides,
development
included,
special
attention
representative
cases,
such
as
polysiloxane,
polytetrafluorethylene,
poly(styrene‐block‐isobutylene‐block‐styrene),
polyurethane‐based
materials.
Finally,
challenges
future
perspectives
artificial
materials
discussed.
Язык: Английский
Light weight- low modulus biocompatible titanium alloys processed via spark plasma sintering
Journal of Alloys and Metallurgical Systems,
Год журнала:
2023,
Номер
3, С. 100018 - 100018
Опубликована: Июнь 16, 2023
There
is
a
wide
range
of
biomedical
applications
for
titanium
and
its
alloys
due
to
their
biological
inertness,
excellent
biocompatibility,
superior
corrosion
resistance,
little
no
adverse
reactions.
However,
the
commonly
used
(Ti-6Al-4
V)
have
been
reported
high
elastic
modulus
(116
GPa)
compared
human
bone
(10–40
GPa),
resulting
in
atrophy
caused
by
stress
shielding,
phenomenon
degradation
an
insufficient
supply
from
implant.
The
presence
aluminum
vanadium
has
also
linked
neurodegenerative
diseases
like
Alzheimer's.
A
new
class
(Ti-35
Nb-7Zr-5Ta
(wt%)
referred
as
TNZT
alloys)
with
low
toxic
alloying
elements
(niobium,
tantalum,
zirconium)
capable
combating
problems
associated
Ti-6Al-4
V
are
being
developed.
In
present
study,
various
physical,
structural,
mechanical,
properties
such
explored,
along
relationship
sintering
processing
parameters
temperature
(400,
600,
800,
1000
°C)
pressure
(20,
40,
60
MPa).
sample
sintered
at
°C
demonstrated
single
β-phase
(BCC)
which
clearly
indicates
that
selected
temperatures
preserve
BCC
without
formation
HCP
α-phase.
Both
density
spark
plasma
(SPS)
samples
increased
increasing
temperature,
underlying
mechanisms
were
discussed.
All
exhibited
biocompatibility
potential
use
long-lasting
high-performance
materials.
Язык: Английский
Polyethylene Glycol Diacrylate Adapted Photopolymerization Material for Contact Lens with Improved Elastic Modulus Properties
Materials,
Год журнала:
2025,
Номер
18(4), С. 827 - 827
Опубликована: Фев. 13, 2025
Four
kinds
of
silicone
hydrogel
transparent
contact
lenses
(CLs)
with
different
formulations
were
prepared
by
the
free
radical
photocuring
polymerization.
By
mixing
polyethylene
glycol
diacrylate
(PEGDA)
1000
Da
ethylene
dimethacrylate
(EGDMA)
and
adding
other
monomers
hydrophilic
monomers,
transparency
flexibility
material
successfully
achieved.
optimizing
weight
percentage
each
component,
best
balance
optical
performance
can
be
The
properties
materials
characterized
electronic
universal
test,
double-beam
UV-visible
spectrophotometer,
Atomic
Force
Microscope
(AFM),
Scanning
Electron
(SEM)
Fourier
Transform
Infrared
Spectroscopy
(FTIR).
results
showed
that
addition
higher
PEGDA
content
reduces
elastic
modulus,
improves
curing
efficiency,
equilibrium
water
(EWC),
enhances
light
transmission.
Hydrogels
containing
only
high
but
no
EGDMA
similar
rates,
content,
had
worst
transparency,
far
inferior
to
mixed
EGDMA.
Additionally,
imaging
CLs
was
further
evaluated
through
simulation
analysis
using
Ansys
Zemax
OpticStudio2024
software.
This
research
provides
a
new
choice
consideration
improve
wearing
comfort
CLs.
Язык: Английский
Ocular contact lenses: smart materials for biomedical applications
Polymer Bulletin,
Год журнала:
2023,
Номер
81(9), С. 7791 - 7832
Опубликована: Дек. 28, 2023
Язык: Английский
Synthesis of silicone hydrogel for soft contact lens (SCLs) and sustainable release of dexamethasone
Reactive and Functional Polymers,
Год журнала:
2023,
Номер
186, С. 105532 - 105532
Опубликована: Фев. 10, 2023
Язык: Английский
Characterization and analysis of extended‐wear silicone hydrogel contact lenses utilizing novel silicone macromers
Journal of Biomedical Materials Research Part A,
Год журнала:
2022,
Номер
110(8), С. 1512 - 1523
Опубликована: Апрель 2, 2022
Contact
lenses
are
one
of
the
most
successful
biomaterials
in
history
with
a
global
market
estimated
to
be
worth
over
$17
billion
2025.
Silicone
hydrogel
contact
dominate
and
complex
biphasic
several
critical
material
properties
needed
for
clinical
use.
Careful
consideration
composition
chemistry
is
identify
formulations
meeting
all
commercial
standards
potential
improved
manufacturability,
cost,
and/or
next
generation
Four
silicone
macromers
were
investigated
this
work
varying
symmetry
siloxane
units
macromer
structure,
number
groups,
branching,
length,
concentration.
Novel
produced
evaluated
optical
transmittance,
elastic
modulus,
oxygen
transmissibility,
water
content,
surface
wettability.
Several
met
demonstrated
an
increase
permeability
(Dk)
inverse
relationship
modulus
concentration,
respectively.
A
hydrophobic/hydrophilic
ratio
below
1.4
was
co-continuous
phase.
Substitution
methoxypropyl
groups
butyl
increased
hydrophobic
microdomains
leading
decreased
quality
mechanical
properties.
Generally,
fluorine-containing
allowed
wider
range
compositions,
above
certain
hydrophilic
composition,
presence
trifluoropropyl
resulted
solubility
optically
clear
lenses.
Data
also
showed
asymmetric
have
meet
lens
at
lower
overall
content.
New
materials
ranges
significant
challenge
may
significantly
expand
field.
Язык: Английский
Design and optimization of acetazolamide nanoparticle-laden contact lens using statistical experimental design for controlled ocular drug delivery
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
35(18), С. 2884 - 2908
Опубликована: Авг. 19, 2024
This
study
aims
to
formulate
and
evaluate
Eudragit
nanoparticles-laden
hydrogel
contact
lenses
for
controlled
delivery
of
acetazolamide
(ACZ)
using
experimental
design.
S-100
was
selected
the
preparation
nanoparticles.
The
optimization
S100
concentration
(X1),
polyvinyl
alcohol
(X2),
sonication
time
(X3)
attempted
by
applying
a
central
composite
Mean
size
nanoparticles
(nm),
percent
Язык: Английский
Effects of Lotrafilcon a and Senofilcon a Bandage Contact Lenses on Visual Outcome and Ocular Comfort after Photorefractive Keratectomy
Опубликована: Янв. 1, 2024
Introduction:
To
compare
the
efficacy
of
two
different
silicone
hydrogel
bandage
contact
lenses
(BCLs)
in
terms
visual
rehabilitation
and
ocular
discomfort
following
photorefractive
keratectomy
(PRK).Methods:
This
prospective
study
included
60
eyes
30
patients
who
underwent
bilateral
PRK
surgery
to
correct
myopia
and/or
astigmatism
refractive
errors.
Following
surgery,
Lotrafilcon
A
were
applied
right
eye
Senofilcon
material
left
eye.
On
postoperative
day
5,
when
BCLs
removed,
subjective
symptoms
evaluated
on
a
scale
0
10,
where
indicated
no
10
maximum
discomfort.
The
spherical
equivalents
(SE)
both
compared
15th
1st
month.
Postoperative
SE
≤
±0.50
diopters
accepted
as
emmetropia.
number
achieved
emmetropia
was
also
month
postoperatively.Results:
scores
did
not
differ
significantly
between
5-day
time
period
(p>0.05).
However,
statistically
significant
difference
observed
their
values
(p
<
0.05).
fitted
with
demonstrated
better
rehabilitation.Conclusion:
Although
significantly,
performed
performance
goal
postoperatively.
Язык: Английский