Frontiers of Materials Science, Год журнала: 2024, Номер 18(3)
Опубликована: Сен. 1, 2024
Язык: Английский
Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136289 - 136289
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
3
Smart Molecules, Год журнала: 2024, Номер 2(1)
Опубликована: Март 1, 2024
Abstract This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, classification hydrogels, explores synthesis responsive capabilities. Specific examined encompass topical drug delivery, contact lenses, intravitreal ocular adhesives, vitreous substitutes, cell‐based therapy. A methodical analysis, including an overview relevant structures comparative evaluation hydrogel‐based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, research areas are identified. Our approach, guided by extensive literature from 2017 to 2023, illuminates unprecedented opportunities offered along pinpointing for further inquiry facilitate transition clinical practice.
Язык: Английский
Процитировано
10
Colloid & Polymer Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
0
Materials, Год журнала: 2025, Номер 18(7), С. 1445 - 1445
Опубликована: Март 25, 2025
A meta-analysis was conducted to assess the evolution of, applications and recent advancements in materials surface treatments for contact lenses. This study aimed comprehensively synthesize available data, focusing on innovations that enhance vision correction, comfort, safety while emphasizing sustainability as a critical factor future development. Registered with PROSPERO, this analysis adhered PRISMA AMSTAR-2 guidelines. systematic review of databases including PubMed, Web Science, Scopus performed studies published between 2019 2024, without language restrictions. Observational optical lens were included, random-effects model used address high heterogeneity among included studies. From nine analyzed, significant identified regarding functional properties treatments. Key technologies like self-lubricating lenses reduce friction, nanogels prolonged therapeutic drug delivery, coatings minimize protein lipid deposition, ensuring greater comfort extended wearability. Additionally, biodegradable eco-friendly underscore industry’s commitment reducing environmental impact lenses, addressing challenges related disposal recycling. These highlight potential integrating improvements sustainability, paving way more effective environmentally responsible
Язык: Английский
Процитировано
0
ACS Applied Polymer Materials, Год журнала: 2024, Номер 6(5), С. 2972 - 2982
Опубликована: Фев. 19, 2024
In transdermal patches, pressure-sensitive adhesives (PSAs) are considered the most critical excipients due to their ability provide adhesion and act as a drug reservoir. However, loaded drugs plasticize resulting in cold flow phenomenon, which poses product safety risk reduces treatment efficacy. Herein, 3-methacryloxypropyltrimethoxysilane (KH-570)-modified hydroxyl acrylate PSA (AAOK) was proposed. Diclofenac, ketoprofen, tulobuterol, oxybutynin were selected model drugs. The results showed that when not with drugs, performance of AAOK significantly different from (AAOH). Interestingly, automatically forms cross-linked system through catalysis, exerts strong antiplasticity without reducing load deliver drug. Specifically, shear strength drug-loaded increased by more than 10-fold compared AAOH. area reduced 15-fold commercial DURO-TAK 87-2287. addition, "dark ring" phenomenon observed 87-2287 on human forearm after loading. After loading four into AAOK, high efficient delivery endowed for vitro vivo. molecular mechanism improved molecules had catalyzing effect self-condensation reactions KH-570. This study opens up ideas investigation patches application.
Язык: Английский
Процитировано
3
Frontiers of Materials Science, Год журнала: 2024, Номер 18(3)
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
0