Type 2 diabetes-related sarcopenia: role of nitric oxide DOI Creative Commons
Zahra Bahadoran, Parvin Mirmiran, Asghar Ghasemi

и другие.

Nutrition & Metabolism, Год журнала: 2024, Номер 21(1)

Опубликована: Дек. 18, 2024

Sarcopenia, characterized by progressive and generalized loss of skeletal muscle (SkM) mass, strength, physical performance, is a prevalent complication in type 2 diabetes (T2D). Nitric oxide (NO), multifunctional gasotransmitter involved whole-body glucose insulin homeostasis, plays key roles normal SkM physiology function. Here, we highlight the role NO mass maintenance its potential contribution to development T2D-related sarcopenia. Physiologic level, primarily produced sarcolemmal neuronal nitric synthase (nNOSμ isoform), protein synthesis fibers mass. The observed effect nNOSμ on muscle-type specific sex-dependent. Impaired homeostasis [due diminished nNOSμ-NO availability excessive production through inducible NOS (iNOS) response atrophic stimuli, e.g., inflammatory cytokines] occurred during progression T2D, may cause Theoretically, restoration nNOS overexpression, supplying substrates (e.g., L-arginine L-citrulline), phosphodiesterase (PDE) inhibition, supplementation with donors inorganic nitrate) be therapeutic approaches preserve prevents sarcopenia T2D.

Язык: Английский

Pathogenesis of Sarcopenia in Chronic Kidney Disease—The Role of Inflammation, Metabolic Dysregulation, Gut Dysbiosis, and microRNA DOI Open Access

Estera Bakinowska,

Joanna Olejnik-Wojciechowska, Kajetan Kiełbowski

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8474 - 8474

Опубликована: Авг. 3, 2024

Chronic kidney disease (CKD) is a progressive disorder associated with decline in function. Consequently, patients advanced stages of CKD require renal replacement therapies, such as dialysis and transplantation. Various conditions lead to the development CKD, including diabetes mellitus, hypertension, glomerulonephritis, among others. The metabolic hormonal dysregulation, uraemia hyperparathyroidism, well low-grade systemic inflammation. Altered homeostasis increases risk developing severe comorbidities, cardiovascular diseases or sarcopenia, which increase mortality. Sarcopenia defined muscle mass However, precise mechanisms that link sarcopenia are poorly understood. Knowledge about these linking might introduction treatment strategies could prevent wasting. This review discusses inflammatory mediators, gut microbiota dysbiosis, non-coding RNA alterations sarcopenia.

Язык: Английский

Процитировано

7
Association of endothelial dysfunction and peripheral arterial disease with sarcopenia in chronic kidney disease DOI Creative Commons
Bang‐Gee Hsu, Chih‐Hsien Wang, Yu‐Hsien Lai

и другие.

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2024, Номер 15(3), С. 1199 - 1208

Опубликована: Апрель 21, 2024

Endothelial dysfunction and peripheral arterial disease (PAD), which disturb skeletal muscle microperfusion, are highly prevalent in patients with chronic kidney (CKD). We evaluated the association of endothelial PAD sarcopenia non-dialysis CKD.

Язык: Английский

Процитировано

4
Towards Precision in Sarcopenia Assessment: The Challenges of Multimodal Data Analysis in the Era of AI DOI Open Access
Valerio Caputo, Ivan Letteri, Silvano Junior Santini

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 4428 - 4428

Опубликована: Май 7, 2025

Sarcopenia, a condition characterised by the progressive decline in skeletal muscle mass and function, presents significant challenges geriatric healthcare. Despite advances its management, complex etiopathogenesis heterogeneity of diagnostic criteria underlie limited precision existing assessment methods. Therefore, efforts are needed to improve knowledge pave way for more effective management precise diagnosis. To this purpose, emerging technologies such as artificial intelligence (AI) can facilitate identification novel accurate biomarkers modelling data resulting from high-throughput technologies, fostering setting up approach. Based on considerations, review explores AI’s transformative potential, illustrating studies that integrate AI, especially machine learning deep learning, with heterogeneous clinical, anthropometric molecular data. Overall, present will highlight relevance large-scale, standardised validate biomarker signatures using AI-driven approaches.

Язык: Английский

Процитировано

0
Type 2 diabetes-related sarcopenia: role of nitric oxide DOI Creative Commons
Zahra Bahadoran, Parvin Mirmiran, Asghar Ghasemi

и другие.

Nutrition & Metabolism, Год журнала: 2024, Номер 21(1)

Опубликована: Дек. 18, 2024

Sarcopenia, characterized by progressive and generalized loss of skeletal muscle (SkM) mass, strength, physical performance, is a prevalent complication in type 2 diabetes (T2D). Nitric oxide (NO), multifunctional gasotransmitter involved whole-body glucose insulin homeostasis, plays key roles normal SkM physiology function. Here, we highlight the role NO mass maintenance its potential contribution to development T2D-related sarcopenia. Physiologic level, primarily produced sarcolemmal neuronal nitric synthase (nNOSμ isoform), protein synthesis fibers mass. The observed effect nNOSμ on muscle-type specific sex-dependent. Impaired homeostasis [due diminished nNOSμ-NO availability excessive production through inducible NOS (iNOS) response atrophic stimuli, e.g., inflammatory cytokines] occurred during progression T2D, may cause Theoretically, restoration nNOS overexpression, supplying substrates (e.g., L-arginine L-citrulline), phosphodiesterase (PDE) inhibition, supplementation with donors inorganic nitrate) be therapeutic approaches preserve prevents sarcopenia T2D.

Язык: Английский

Процитировано

0