The Circadian Timekeeping System of Drosophila

Current Biology, Год журнала: 2005, Номер 15(17), С. R714 - R722

Опубликована: Сен. 1, 2005

Язык: Английский

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Insect Diapause

Опубликована: Янв. 13, 2022

Our highly seasonal world restricts insect activity to brief portions of the year. This feature necessitates a sophisticated interpretation changes and enactment mechanisms for bringing development halt then reinitiating it when inimical season is past. The dormant state diapause serves bridge unfavourable seasons, its timing provides powerful mechanism synchronizing development. book explores how signals are monitored used by insects enact specific molecular pathways that generate phenotype. broad perspective offered here scales from ecological thus comprehensive view this exciting vibrant research field, offering insights on topics ranging pest management, evolution, speciation, climate change disease transmission, human health, as well analogies with other forms invertebrate dormancy mammalian hibernation.

Язык: Английский

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The Neuropeptide Pigment-Dispersing Factor Coordinates Pacemaker Interactions in theDrosophilaCircadian System

Journal of Neuroscience, Год журнала: 2004, Номер 24(36), С. 7951 - 7957

Опубликована: Сен. 8, 2004

In Drosophila , the neuropeptide pigment-dispersing factor (PDF) is required to maintain behavioral rhythms under constant conditions. To understand how PDF exerts its influence, we performed time-series immunostainings for PERIOD protein in normal and pdf mutant flies over 9 d of Without pacemaker neurons that normally express maintained two markers rhythms: nuclear translocation staining intensity. As a group, however, they displayed gradual dispersion their phasing translocation. A separate group non-PDF circadian pacemakers also without but exhibited altered phase amplitude Therefore, not oscillations conditions; it coordinate such among diverse pacemakers. These observations begin outline hierarchy circuitry brain.

Язык: Английский

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A G Protein-Coupled Receptor, groom-of-PDF, Is Required for PDF Neuron Action in Circadian Behavior

Neuron, Год журнала: 2005, Номер 48(2), С. 221 - 227

Опубликована: Окт. 1, 2005

Язык: Английский

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Circadian Remodeling of Neuronal Circuits Involved in Rhythmic Behavior

PLoS Biology, Год журнала: 2008, Номер 6(3), С. e69 - e69

Опубликована: Март 18, 2008

Clock output pathways are central to convey timing information from the circadian clock a diversity of physiological systems, ranging cell-autonomous processes behavior. While molecular mechanisms that generate and sustain rhythmicity at cellular level well understood, it is unclear how this further structured control specific behavioral outputs. Rhythmic release pigment dispersing factor (PDF) has been proposed propagate time day core pacemaker cells downstream targets underlying rhythmic locomotor activity. Indeed, such changes in PDF intensity represent only known mechanism through which circuit could communicate with its output. Here we describe novel phenomenon involving extensive remodeling axonal terminals circuit, display higher complexity during significantly lower nighttime, both under daily cycles constant conditions. In support nature, cycling lost bona fide clockless mutants. We propose clock-controlled structural plasticity as candidate contributing transmission cells.

Язык: Английский

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Development and morphology of the clock‐gene‐expressing lateral neurons of Drosophila melanogaster

The Journal of Comparative Neurology, Год журнала: 2006, Номер 500(1), С. 47 - 70

Опубликована: Ноя. 10, 2006

The clock-gene-expressing lateral neurons are essential for the locomotor activity rhythm of Drosophila melanogaster. Traditionally, these divided into three groups: dorsal (LN(d)), large ventral (l-LN(v)), and small (s-LN(v)), whereby latter group consists four that express neuropeptide pigment-dispersing factor (PDF) a fifth PDF-negative neuron. So far, only l-LN(v) PDF-positive s-LN(v) have been shown to project accessory medulla, neuropil contains circadian pacemaker center in several insects. We show here other also arborize predominantly forming postsynaptic sites. Both LN(d) anatomically well suited connect medullae. Whereas may receive ipsilateral photic input from Hofbauer-Buchner eyelet, invade mainly contralateral medulla thus side. differentiate during midmetamorphosis. They do so close proximity one another s-LN(v), suggesting cell groups derive common precursors.

Язык: Английский

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Genetic analysis of the circadian system in Drosophila melanogaster and mammals

Journal of Neurobiology, Год журнала: 2002, Номер 54(1), С. 111 - 147

Опубликована: Дек. 16, 2002

Abstract The fruit fly, Drosophila melanogaster , has been a grateful object for circadian rhythm researchers over several decades. Behavioral, genetic, and molecular studies helped to reveal the genetic bases of time keeping rhythmic behaviors. Contrary, mammalian research until recently was mainly restricted descriptive physiologic approaches. As in many other areas research, surprising similarity basic biologic principles between little fly our own species, boosted progress unraveling foundation clock mechanisms. Once more, not only mechanisms, but also molecules involved establishing system are taken or adapted from fly. This review will try give comparative overview about two systems, highlighting similarities as well specifics both insect murine clocks. © 2003 Wiley Periodicals, Inc. J Neurobiol 54: 111–147,

Язык: Английский

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Cryptochrome, Compound Eyes, Hofbauer-Buchner Eyelets, and Ocelli Play Different Roles in the Entrainment and Masking Pathway of the Locomotor Activity Rhythm in the Fruit Fly Drosophila Melanogaster

Journal of Biological Rhythms, Год журнала: 2003, Номер 18(5), С. 377 - 391

Опубликована: Окт. 1, 2003

The fly Drosophila melanogaster possesses five photoreceptors and/or photopigments that appear to be involved in light reception and synchronization of the circadian clock: (1) compound eyes, (2) ocelli, (3) Hofbauer-Buchner eyelets, (4) blue-light photopigment cryptochrome, (5) unknown clock-gene-expressing dorsal neurons. To understand contributions these synchronization, authors monitored flies' activity rhythms under artificial long short days. They found all different photo-pigments contribute significantly entrainment each photoperiod, but eyes are especially important for extreme photoperiods. are, furthermore, necessary adjusting phase rhythm, distinguishing days from constant light, normal masking effects light—namely, promotion by lights-on inhibition darkness. Cryptochrome is period lengthening days, although it more than is, after photoperiod on internal clock. specific roles remaining difficult assess.

Язык: Английский

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Reevaluation ofDrosophila melanogaster's neuronal circadian pacemakers reveals new neuronal classes

The Journal of Comparative Neurology, Год журнала: 2006, Номер 498(2), С. 180 - 193

Опубликована: Янв. 1, 2006

In the brain of fly Drosophila melanogaster, ∼150 clock-neurons are organized to synchronize and maintain behavioral rhythms, but physiological neurochemical bases their interactions largely unknown. Here we reevaluate cellular properties these pacemakers by application a novel genetic reporter several phenotypic markers. First, describe an enhancer trap marker called R32 that specifically reveals previously undescribed aspects fly's central neuronal pacemakers. We find evidence for unappreciated class pacemakers, lateral posterior neurons (LPNs), establish anatomical, molecular, developmental criteria subclass within dorsal neuron 1 (DN1) group Furthermore, show neuropeptide IPNamide is expressed this DN1 subclass. These observations implicate as second candidate circadian transmitter in brain. Finally, present molecular anatomical unrecognized diversity each four established classes clock neurons. J. Comp. Neurol. 498:180–193, 2006. © 2006 Wiley-Liss, Inc.

Язык: Английский

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Neuropeptides in interneurons of the insect brain

Cell and Tissue Research, Год журнала: 2006, Номер 326(1), С. 1 - 24

Опубликована: Июнь 7, 2006

Язык: Английский

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