Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

Nanomaterials, Год журнала: 2020, Номер 10(2), С. 292 - 292

Опубликована: Фев. 9, 2020

Metal-based nanoparticles have been extensively investigated for a set of biomedical applications. According to the World Health Organization, in addition their reduced size and selectivity bacteria, metal-based also proved be effective against pathogens listed as priority. are known non-specific bacterial toxicity mechanisms (they do not bind specific receptor cell) which only makes development resistance by bacteria difficult, but broadens spectrum antibacterial activity. As result, large majority efficacy studies performed so far shown promising results both Gram-positive Gram-negative bacteria. The aim this review has comprehensive discussion state art on use most relevant types metal employed antimicrobial agents. A special emphasis silver is given, while others (e.g., gold, zinc oxide, copper, copper oxide nanoparticles) commonly used antibiotherapy reviewed. novelty relies comparative different nanoparticles, production methods, physicochemical characterization, pharmacokinetics together with toxicological risk encountered Their added-value alternative, more antibiotics multi-resistant highlighted.

Язык: Английский

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Silver Nanoparticles: Bactericidal and Mechanistic Approach against Drug Resistant Pathogens

Microorganisms, Год журнала: 2023, Номер 11(2), С. 369 - 369

Опубликована: Фев. 1, 2023

This review highlights the different modes of synthesizing silver nanoparticles (AgNPs) from their elemental state to particle format and mechanism action against multidrug-resistant biofilm-forming bacterial pathogens. Various studies have demonstrated that AgNPs cause oxidative stress, protein dysfunction, membrane disruption, DNA damage in bacteria, ultimately leading death. also been found alter adhesion cells prevent biofilm formation. The benefits using medicine are, some extent, counter-weighted by toxic effect on humans environment. In this review, we compiled recent demonstrating antibacterial activity AgNPs, are discussing known mechanisms Ongoing clinical trials involving briefly presented. A particular focus is placed interaction with biofilms, which a significant pathogenicity determinant. brief overview use other medical applications (e.g., diagnostics, promotion wound healing) non-medical sectors Finally, current drawbacks limitations discussed, perspectives for improved future functionalized

Язык: Английский

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Green Synthesis and Potential Antibacterial Applications of Bioactive Silver Nanoparticles: A Review

Polymers, Год журнала: 2022, Номер 14(4), С. 742 - 742

Опубликована: Фев. 15, 2022

Green synthesis of silver nanoparticles (AgNPs) using biological resources is the most facile, economical, rapid, and environmentally friendly method that mitigates drawbacks chemical physical methods. Various such as plants their different parts, bacteria, fungi, algae, etc. could be utilized for green bioactive AgNPs. In recent years, several approaches non-toxic, facile AgNPs have been reported. Plant extract contains various biomolecules, including flavonoids, terpenoids, alkaloids, phenolic compounds, vitamins act reducing capping agents during biosynthesis process. Similarly, microorganisms produce primary secondary metabolites play a crucial role synthesis. Biosynthesized gained significant attention from researchers because potential applications in fields biomedical science. The widest application bactericidal activity. Due to emergence multidrug-resistant microorganisms, are exploring therapeutic abilities antibacterial agents. Already, reports suggested biosynthesized exhibited action against numerous human pathogens. Because small size large surface area, ability easily penetrate bacterial cell walls, damage membranes, reactive oxygen species, interfere with DNA replication well protein synthesis, result death. This paper provides an overview green, rapid use AgNPs, highlighting mechanisms.

Язык: Английский

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Microbial Nano-Factories: Synthesis and Biomedical Applications

Frontiers in Chemistry, Год журнала: 2021, Номер 9

Опубликована: Апрель 16, 2021

In the recent times, nanomaterials have emerged in field of biology, medicine, electronics, and agriculture due to their immense applications. Owing nanoscale sizes, they present large surface/volume ratio, characteristic structures, similar dimensions biomolecules resulting unique properties for biomedical The chemical physical methods synthesize nanoparticles own limitations which can be overcome using biological synthesis. Moreover, through biogenic synthesis route, usage microorganisms has offered a reliable, sustainable, safe, environmental friendly technique nanosynthesis. Bacterial, algal, fungal, yeast cells are known transport metals from environment convert them elemental nanoparticle forms either accumulated or secreted. Additionally, robust nanocarriers also been developed viruses. order prevent aggregation promote stabilization nanoparticles, capping agents often secreted during biosynthesis. Microbial find applications rapid diagnostics, imaging, biopharmaceuticals, drug delivery systems, antimicrobials, biomaterials tissue regeneration as well biosensors. major challenges therapeutic microbial include biocompatibility, bioavailability, stability, degradation gastro-intestinal tract, immune response. Thus, current review article is focused on microbe-mediated various different strains explored such along with future

Язык: Английский

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A review on biological synthesis of silver nanoparticles and their potential applications

Results in Chemistry, Год журнала: 2023, Номер 6, С. 101108 - 101108

Опубликована: Сен. 11, 2023

Silver nanoparticles are an important innovation in nanotechnology, due to their high stability and low chemical reactivity comparison other metals. have received much attention biological application because of unique physicochemical properties. A number methods applied synthesize silver such as physical chemical. These commonly synthesized using toxic chemicals reducing agents. However, the last few decades, several efforts were made develop green synthesis avoid use hazardous materials. In present review we describe bacteria, fungi plants, role plant metabolites process. Several biomolecules included extract, flavonoids, terpenoids, alkaloids, phenolic compounds, vitamins, function capping agents during biosynthesis The prospective uses biosynthesized AgNPs different fields, including antifungal, antibacterial, antiviral, agronomic, attracted researchers.

Язык: Английский

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Fabrication of Silver Nanoparticles Against Fungal Pathogens

Frontiers in Nanotechnology, Год журнала: 2021, Номер 3

Опубликована: Окт. 8, 2021

The use of silver nanoparticles (AgNPs) against various pathogens is now being well recognized in the agriculture and health sector. Nanoparticles have been shown to exhibit novel properties these properties, on other hand, rely upon size, shape, morphology particles. Moreover, physical characteristics enable them interact with microbes, plants, animals. Smaller-sized particles more toxicity than larger-sized nanoparticles. AgNPs growth inhibition many fungi like Aspergillus fumigates , A. niger flavus Trichophyton rubrum Candida albicans Penicillium species. According current hypothesis, act by producing reactive oxygen species free radicals, which cause protein denaturation, nucleic acid proton pump damage, lipid peroxidation, cell wall damage. Therefore, they alter membrane permeability, causing death. This mini-review summarizes fungal biofilm agricultural

Язык: Английский

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Nanoparticles: Mechanism of biosynthesis using plant extracts, bacteria, fungi, and their applications

Journal of Molecular Liquids, Год журнала: 2021, Номер 334, С. 116040 - 116040

Опубликована: Апрель 6, 2021

Язык: Английский

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Noble metal-based nanomaterials as antibacterial agents

Journal of Alloys and Compounds, Год журнала: 2022, Номер 904, С. 164091 - 164091

Опубликована: Фев. 4, 2022

Язык: Английский

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Bimetallic Assembled Silver Nanoparticles Impregnated in Aspergillus fumigatus Extract Damage the Bacterial Membrane Surface and Release Cellular Contents

Coatings, Год журнала: 2022, Номер 12(10), С. 1505 - 1505

Опубликована: Окт. 9, 2022

The bactericidal effects of nanomaterials play an essential role in cytoplasmic leakage, leading to bacterial cell death. In this study, silver nanoparticles (AgNPs) were synthesized using a fungal extract Aspergillus fumigatus (A. fumigatus). physicochemical properties the bare and myco-synthesized AgNPs (MS-AgNPs) examined by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, ultraviolet–visible (UV–vis) scanning electron microscopy (SEM), energy dispersive spectroscopy (EDX), transmission (TEM). XRD revealed crystalline structure prepared NPs. FTIR spectrum MS-AgNPs presence stretching vibrations hydroxyl (−OH) carbonyl groups (C=O). UV results showed absorption from 450 nm 590 nm, confirming synthesis AgNPs. SEM TEM rough cubic shapes (spheres), 20–60 size, while EDX confirmed 60% Ag sample. highest antibacterial activity against Staphylococcus aureus, with zone inhibition 18.21 ± 2.1 mm, followed Shigella dysenteriae Salmonella typhi. bimetallic-AgNPs played vital membrane damage release cellular contents, specifically nucleic acids proteins. These suggest that have promising antimicrobial capabilities might be beneficial for extensive array biological applications.

Язык: Английский

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Biosynthesized metallic nanoparticles as fertilizers: An emerging precision agriculture strategy

Journal of Integrative Agriculture, Год журнала: 2022, Номер 21(5), С. 1225 - 1242

Опубликована: Апрель 7, 2022

Nanofertilizers increase efficiency and sustainability of agricultural crop production. Due to their nanosize properties, they have been shown productivity through target delivery or slow release nutrients, thereby limiting the rate fertilizer application required. can be synthesized via different approaches ranging from physical chemical green (biological) synthesis. The approach is preferable because it makes use less chemicals, producing contamination safer in comparison physicochemical approaches. Hence, discussion on nanoparticles as nanofertilizers pertinent for a sustainable agriculture. This review discusses recent developments applications biologically metallic that also used nanofertilizers, well uptake mechanisms plant growth. Toxicity concerns nanoparticle agriculture are discussed.

Язык: Английский

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