Frontiers in Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 9, 2025
Klebsiella
pneumoniae
is
a
significant
nosocomial
pathogen
that
has
developed
resistance
to
multiple
antibiotics,
often
forming
biofilms
enhance
its
virulence.
This
study
investigated
the
efficacy
of
novel
nanoformulation,
AgNPs@chitosan-NaF,
in
combating
K.
biofilms.
Antimicrobial
susceptibility
testing
was
performed
assess
antibiotic
profile
isolates.
The
antibiofilm
activity
AgNPs@chitosan-NaF
evaluated
using
crystal
violet
staining
and
scanning
electron
microscopy.
underlying
mechanisms
action
were
through
gene
expression
analysis.
majority
isolates
exhibited
high
levels
multidrug
resistance.
demonstrated
superior
biofilm
inhibition
compared
AgNPs@chitosan,
significantly
reducing
biomass
disrupting
architecture
at
MICs
ranging
from
0.125
1
μg/mL.
Mechanistic
studies
revealed
nanoformulation
downregulated
key
biofilm-associated
genes,
including
treC,
fimA,
mrkA,
ecpA.
While
concentration-dependent
cytotoxic
effect
on
both
normal
cancer
cell
lines,
minimal
cytotoxicity
observed
concentrations
below
31.25
highlights
synergistic
silver
nanoparticles,
chitosan,
sodium
fluoride
emerges
as
promising
therapeutic
strategy
address
challenge
multidrug-resistant
bacterial
infections.
Nanomaterials,
Год журнала:
2024,
Номер
14(18), С. 1527 - 1527
Опубликована: Сен. 20, 2024
Recently,
silver
nanoparticles
(NPs)
have
attracted
significant
attention
for
being
highly
desirable
nanomaterials
in
scientific
studies
as
a
result
of
their
extraordinary
characteristics.
They
are
widely
known
effective
antibacterial
agents
that
capable
targeting
wide
range
pathogens.
Their
distinct
optical
characteristics,
such
localized
surface
plasmon
resonance,
enlarge
utilization,
particularly
the
fields
biosensing
and
imaging.
Also,
capacity
to
control
charge
modify
them
using
biocompatible
substances
offers
improved
durability
specific
interactions
with
biological
systems.
Due
exceptional
stability
minimal
chemical
reactivity,
NPs
suitable
diverse
array
applications.
These
produced
through
chemical,
biological,
physical
processes,
each
which
has
advantages
disadvantages.
Chemical
techniques
often
encounter
issues
complicated
purification,
reactive
substances,
excessive
energy
usage.
However,
eco-friendly
approaches
exist,
even
though
they
require
longer
processing
times.
A
key
factor
affecting
stability,
size
distribution,
purity
is
synthesis
process
selected.
This
review
focuses
on
how
essential
it
choose
appropriate
method
order
optimize
characteristics
use
NPs.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 31, 2024
Nanoparticles
play
a
crucial
role
in
the
field
of
nanotechnology,
offering
different
properties
due
to
their
surface
area
attributed
small
size.
Among
them,
silver
nanoparticles
(AgNPs)
have
attracted
significant
attention
antimicrobial
properties,
with
applications
that
date
back
from
ancient
medicinal
practices
contemporary
commercial
products
containing
ions
or
nanoparticles.
AgNPs
possess
broad-spectrum
biocidal
potential
against
bacteria,
fungi,
viruses,
and
Mycobacterium,
addition
exhibiting
synergistic
effects
when
combined
certain
antibiotics.
The
mechanisms
underlying
its
action
include
generation
oxygen-reactive
species,
damage
DNA,
rupture
bacterial
cell
membranes
inhibition
protein
synthesis.
Recent
studies
highlighted
effectiveness
various
clinically
relevant
strains
through
combat
antibiotic-resistant
pathogens.
This
review
investigates
proteomic
by
which
exert
effects,
special
focus
on
activity
planktonic
bacteria
biofilms.
Furthermore,
it
discusses
biomedical
non-preparation
antibiotic
formulations,
also
addressing
issue
resistance
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 8, 2024
Silver
nanoparticles
(AgNPs)
have
gained
significant
attention
in
biomedical
applications
due
to
their
unique
physicochemical
properties.
This
review
focuses
on
the
roles
of
AgNPs
antimicrobial
activity,
anticancer
therapy,
and
wound
healing,
highlighting
potential
address
critical
health
challenges.
Highlights
CPL-AgNPs
exhibited
improved
biomimetic
attributes.
Antibiotic
resistance
against
pathogens
were
challenged
through
use
of
CPL-AgNPs.
Supercapacitor
application
facile
synthesized
AgNPs
for
the
first
time
demonstrated
physical
application.
Silver
nanoparticles
(AgNPs)
are
widely
recognized
for
their
unique
optical,
electronic,
and
antibacterial
properties,
enabling
use
in
biosensing,
photonics,
electronics,
drug
delivery,
antimicrobial
treatments.
Green
chemistry-based
biological
synthesis
methods
offer
an
eco-friendly
alternative
to
traditional
chemical
techniques.
Among
metallic
(NPs)
metal
oxides,
those
derived
from
plant
extracts
exhibit
notable
medicinal
properties.
Due
exceptional
stability
low
reactivity,
AgNPs
particularly
well-suited
various
applications.
can
be
synthesized
through
chemical,
physical,
or
methods,
each
with
distinct
benefits
challenges.
Chemical
physical
approaches
often
involve
complex
purification,
reactive
reagents,
high
energy
demands,
while
though
slower,
provide
sustainable
solutions.
The
chosen
method
strongly
influences
the
stability,
size,
purity
of
resulting
NPs.
This
review
emphasizes
importance
selecting
appropriate
optimize
characteristics
functionality
silver
It
consolidates
research
spanning
past
two
decades,
including
most
recent
findings
2024.
A
comprehensive
electronic
search
databases
such
as
PubMed,
Scopus,
ScienceDirect,
Cochrane,
Google
Scholar
was
conducted
up-to-date
overview
advances
applications
nanoparticles.
Coatings,
Год журнала:
2025,
Номер
15(1), С. 33 - 33
Опубликована: Янв. 2, 2025
In
recent
decades,
the
integration
of
nanotechnology
into
dentistry
has
led
to
groundbreaking
advancements
in
dental
materials
and
applications.
This
article
explores
role
nanoparticles
(NPs)
modern
dentistry,
highlighting
their
definitions,
unique
properties,
various
The
introduction
establishes
significance
health
care,
emphasizing
potential
NPs
transform
traditional
practices.
overview
includes
a
discussion
fundamental
properties
NPs,
which
contribute
effectiveness
categorizes
three
main
groups:
antimicrobial,
therapeutic,
material
property-improving
detailing
clinical
uses
mechanisms
action.
Furthermore,
it
addresses
current
innovations
products
incorporating
examines
emerging
trends
field.
research
for
this
review
was
conducted
using
high-quality,
peer-reviewed
scientific
databases,
including
PubMed,
Scopus,
Web
Science,
Google
Scholar,
with
no
time
restriction
as
an
inclusion
criterion.
These
databases
were
selected
credibility
comprehensive
collections
relevant
studies.
conclusion,
represent
promising
avenue
innovation
therapeutics.
Their
enable
development
enhanced
antimicrobial
agents,
effective
drug
delivery
systems,
improved
performance.
However,
risks
associated
cytotoxicity
stability
must
be
carefully
managed
ensure
safe
use.
Ongoing
is
essential
fully
understand
optimize
applications
balancing
benefits
against
risks.
As
field
advances,
practice
will
likely
revolutionize
approaches
care
treatment.
