Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence DOI Creative Commons
Carmen Scheibenbogen, Klaus Wirth

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2024, Номер 16(1)

Опубликована: Дек. 27, 2024

ABSTRACT Background Recent studies provide strong evidence for a key role of skeletal muscle pathophysiology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In 2021 review article on the ME/CFS, we postulated that hypoperfusion and ischemia can result excessive sodium calcium overload muscles ME/CFS patients to cause mitochondrial damage. Since then, experimental has been provided supports this concept. Methods We collect, summarize discuss current state knowledge pathophysiology. try explain which risk factors mechanisms are responsible subgroup with post COVID (PCS) develop (PC‐ME/CFS). Results Mitochondrial dysfunction is long‐held assumption cardinal symptoms ME/CFS. However, could not be convincingly shown leukocytes. By contrast, recent tissue An electron microscopy study directly show damage mitochondria preferential subsarcolemmal localization but PCS. Another shows signs regeneration biopsies taken one day after exercise PC‐ME/CFS. The simultaneous presence necroses concept repeated Other correlated diminished hand grip strength (HGS) symptom severity prognosis. A MRI showed intracellular elevated levels correlate inversely HGS. This finding corroborates our consecutive as muscular caused by enhanced proton‐sodium exchange due anaerobic metabolism activity sodium‐potassium‐ATPase. histological investigations exclude microvascular obstruction, viral or immune myositis. only known exercise‐induced mechanism left induced overload. If ionic disturbance severe enough patient may captured vicious circle. energy deficit most likely exertional intolerance malaise further aggravated exertion. Conclusion Based pathomechanism, future treatment approaches should focus normalizing disbalance. Current strategies targeting have potential improve ion transporters.

Язык: Английский

Muscle-derived extracellular vesicles mediate crosstalk between skeletal muscle and other organs DOI Creative Commons

Jiajie Jia,

Lu Wang, Yue Zhou

и другие.

Frontiers in Physiology, Год журнала: 2025, Номер 15

Опубликована: Янв. 8, 2025

Skeletal muscle (SKM) has crucial roles in locomotor activity and posture within the body also functions have been recognized as an actively secretory organ. Numerous bioactive molecules are secreted by SKM transported extracellular vesicles (EVs), a novel class of mediators communication between cells organs that contain various types cargo including lipids, proteins nucleic acids. SKM-derived EVs (SKM-EVs) intercellular communicators with significant crosstalk other organs. In this review, we briefly describe biological characteristics, composition, uptake mechanisms EVs, particularly exosomes, comprehensively summarize regulatory effects SKM-EVs on function of, which include myogenesis, repair regeneration, well metabolic regulation. Furthermore, explore impact SKM- bone, cardiovascular system, adipose tissue, nervous system. As emerging evidence suggests involved development regulation type 2 diabetes (T2D), systemic inflammation, chronic diseases, highlight potential therapeutic targets diagnostic biomarkers, emphasizing need for further research to elucidate complex underlying physiological pathological contexts.

Язык: Английский

Процитировано

1
Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise DOI Creative Commons
Ludovic Giloteaux, Katherine A. Glass, Arnaud Germain

и другие.

Journal of Extracellular Vesicles, Год журнала: 2024, Номер 13(1)

Опубликована: Янв. 1, 2024

In healthy individuals, physical exercise improves cardiovascular health and muscle strength, alleviates fatigue reduces the risk of chronic diseases. Although is suggested as a lifestyle intervention to manage various illnesses, it negatively affects people with myalgic encephalomyelitis/chronic syndrome (ME/CFS), who suffer from intolerance. We hypothesized that altered extracellular vesicle (EV) signalling in ME/CFS patients after an challenge may contribute their prolonged exacerbated negative response exertion (post-exertional malaise). EVs were isolated by size exclusion chromatography plasma 18 female 17 age- BMI-matched sedentary controls at three time points: before, 15 min, 24 h maximal cardiopulmonary test. characterized using nanoparticle tracking analysis protein cargo was quantified Tandem Mass Tag-based (TMT) proteomics. The results show EV proteome differently than individuals changes proteins are strongly correlated symptom severity ME/CFS. Differentially abundant versus involved many pathways systems, including coagulation processes, contraction (both smooth skeletal muscle), cytoskeletal proteins, immune system brain signalling.

Язык: Английский

Процитировано

7
Towards an understanding of physical activity-induced post-exertional malaise: Insights into microvascular alterations and immunometabolic interactions in post-COVID condition and myalgic encephalomyelitis/chronic fatigue syndrome DOI Creative Commons
Simon Haunhorst, Diana Dudziak, Carmen Scheibenbogen

и другие.

Infection, Год журнала: 2024, Номер unknown

Опубликована: Сен. 6, 2024

Язык: Английский

Процитировано

5
From sweat to hope: The role of exercise‐induced extracellular vesicles in cancer prevention and treatment DOI Creative Commons
Alicia Llorente,

Agnese Brokāne,

Agata Mlynska

и другие.

Journal of Extracellular Vesicles, Год журнала: 2024, Номер 13(8)

Опубликована: Авг. 1, 2024

Abstract The benefits of regular physical exercise on cancer prevention, as well reducing fatigue, treatment side effects and recurrence, improving quality life overall survival patients, are increasingly recognised. Initial studies showed that the concentration extracellular vesicles (EVs) increases during activity EVs carry biologically active cargo. These released by blood cells, skeletal muscle other organs involved in exercise, thus suggesting may mediate tissue crosstalk exercise. This possibility triggered a great interest study roles systemic adaptation to their potential applications prevention various diseases, including cancer. review presents exploring molecular cargo Furthermore, we discuss putative stimuli trigger EV release from cell types, biological functions impact exercise‐induced development progression. Understanding interplay between EVs, biology offer insights into novel therapeutic strategies preventive measures for

Язык: Английский

Процитировано

4
Stellate Ganglion Block reduces symptoms of SARS-CoV-2-induced ME/CFS: A prospective cohort pilot study DOI Creative Commons
Deborah Duricka,

Luke D. Liu

Fatigue Biomedicine Health & Behavior, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Фев. 6, 2025

Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating condition characterized by fatigue, orthostatic intolerance (OI), post-exertional malaise (PEM) and unrefreshing sleep. Our previous work has shown that modulating the autonomic nervous system can alleviate symptoms of Long COVID, which shares striking similarities with ME/CFS.

Язык: Английский

Процитировано

0
Cerebrospinal fluid metabolomics, lipidomics and serine pathway dysfunction in myalgic encephalomyelitis/chronic fatigue syndroome (ME/CFS) DOI Creative Commons
James N. Baraniuk

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 3, 2025

We proposed that cerebrospinal fluid would provide objective evidence for disrupted brain metabolism in myalgic encephalomyelitis/chronic fatigue syndroome (ME/CFS). The concept of postexertional malaise (PEM) with disabling symptom exacerbation after limited exertion does not respond to rest is a diagnostic criterion ME/CFS. submaximal exercise provocation cause additional metabolic perturbations. metabolomic and lipidomic constituents from separate nonexercise postexercise cohorts ME/CFS sedentary control subjects were contrasted using targeted mass spectrometry (Biocrates) frequentist multivariate general linear regression analysis diagnosis, exercise, gender, age body index as independent variables. diagnosis was associated elevated serine but reduced 5-methyltetrahydrofolate (5MTHF). One carbon pathways disrupted. Methylation glycine led sarcosine further methylation dimethylglycine choline decreased. Creatine purine intermediates elevated. Transaconitate the tricarboxylic acid cycle along essential aromatic amino acids, lysine, purine, pyrimidine microbiome metabolites. Serine precursor phospholipids sphingomyelins also Exercise consumption lipids controls while metabolites consumed generated controls. findings differ prior hypometabolic plasma. novel generate new hypotheses regarding serine-folate-glycine one serine-phospholipid metabolism, elevation end products catabolic pathways, shifts folate, thiamine other vitamins changes may indicate myelin white matter dysfunction

Язык: Английский

Процитировано

0
Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence DOI Creative Commons
Carmen Scheibenbogen, Klaus Wirth

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2024, Номер 16(1)

Опубликована: Дек. 27, 2024

ABSTRACT Background Recent studies provide strong evidence for a key role of skeletal muscle pathophysiology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In 2021 review article on the ME/CFS, we postulated that hypoperfusion and ischemia can result excessive sodium calcium overload muscles ME/CFS patients to cause mitochondrial damage. Since then, experimental has been provided supports this concept. Methods We collect, summarize discuss current state knowledge pathophysiology. try explain which risk factors mechanisms are responsible subgroup with post COVID (PCS) develop (PC‐ME/CFS). Results Mitochondrial dysfunction is long‐held assumption cardinal symptoms ME/CFS. However, could not be convincingly shown leukocytes. By contrast, recent tissue An electron microscopy study directly show damage mitochondria preferential subsarcolemmal localization but PCS. Another shows signs regeneration biopsies taken one day after exercise PC‐ME/CFS. The simultaneous presence necroses concept repeated Other correlated diminished hand grip strength (HGS) symptom severity prognosis. A MRI showed intracellular elevated levels correlate inversely HGS. This finding corroborates our consecutive as muscular caused by enhanced proton‐sodium exchange due anaerobic metabolism activity sodium‐potassium‐ATPase. histological investigations exclude microvascular obstruction, viral or immune myositis. only known exercise‐induced mechanism left induced overload. If ionic disturbance severe enough patient may captured vicious circle. energy deficit most likely exertional intolerance malaise further aggravated exertion. Conclusion Based pathomechanism, future treatment approaches should focus normalizing disbalance. Current strategies targeting have potential improve ion transporters.

Язык: Английский

Процитировано

3