Osteoporosis
(OP)
is
a
systemic
and
retrogressive
disease
characterized
by
decreased
bone
density
fragile
microstructure.
Extracellular
vesicles
(EVs),
cell‐free
system
with
phospholipid
bilayer
released
cells
that
cannot
be
replicated,
have
unique
nanostructure,
stable
drug‐loading
capacity,
good
biocompatibility,
playing
an
important
role
in
regulating
the
gut‐skeletal
axis.
A
growing
body
of
research
demonstrates
gut
microbiota
(GM)
influence
development
OS,
while
bacteria‐derived
EVs
(BEVs)
become
new
dialogue
medium
between
bone.
Additionally,
organoids
are
3D
cell
clusters
vitro
highly
simulate
structure
function
corresponding
organs.
Intestinal
organoids‐derived
(IOEVs)
serve
as
another
promising
communication
due
to
their
significant
physiological
effects.
Herein,
three
types
gut‐bone
axes,
including
traditional,
BEVs‐based,
IOEVs‐based
axes
innovatively
proposed.
The
impact
BEVs‐based
on
OP
focused.
comprehensive
summary
will
reveal
relationship
intestinal
provide
solution
therapy.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 7, 2024
Scutellarin
(SCU),
a
flavonoid
glucuronide
derived
from
Scutellaria
barbata
and
Erigeron
breviscapus
,
exhibits
broad
pharmacological
effects
with
promising
therapeutic
potential
in
treating
various
chronic
diseases.
It
has
demonstrated
efficacy
modulating
multiple
biological
pathways,
including
antioxidant,
anti-inflammatory,
anti-apoptotic,
vasodilatory
mechanisms.
These
protective
roles
make
SCU
valuable
compound
diseases
such
as
cerebrovascular
diseases,
cardiovascular
neurodegenerative
disorders,
metabolic
Despite
its
multi-targeted
effects,
faces
challenges
low
bioavailability
limited
clinical
data,
which
hinder
widespread
application.
Current
research
supports
to
prevent
oxidative
stress,
reduce
inflammatory
responses,
enhance
cell
survival
cells
rats.
However,
more
comprehensive
studies
are
required
clarify
molecular
mechanisms
develop
strategies
that
for
use.
could
emerge
potent
agent
the
treatment
of
complex
pathophysiological
This
review
examines
current
literature
on
provide
understanding
activity,
action,
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 19, 2024
Extracellular
vesicles
(EVs),
especially
those
derived
from
stem
cells,
have
emerged
as
a
novel
treatment
for
promoting
wound
healing
in
regenerative
medicine.
However,
the
clinical
application
of
mammalian
cells-derived
EVs
is
hindered
by
their
high
cost
and
low
yields.
Inspired
ability
to
mediate
interkingdom
communication,
we
explored
therapeutic
potential
released
probiotic
strain
Lactobacillus
rhamnosus
GG
(LGG)
skin
elucidated
underlying
mechanism
involved.
Using
full-thickness
wound-healing
mouse
models,
found
that
LGG-EVs
accelerated
procedures,
including
increased
re-epithelialization
promoted
angiogenesis.
vitro
experiments,
further
demonstrated
boosted
proliferation
migration
capacities
both
epithelial
endothelial
well
tube
formation.
miRNA
profiling
analysis
revealed
miR-21-5p
was
highly
enriched
LGG-EV
significantly
level
recipient
cells.
Mechanically,
induced
regulatory
effects
via
mediated
metabolic
signaling
rewiring.
Our
results
suggest
LGG
could
serve
promising
candidate
accelerating
possibly
treating
chronic
impaired
conditions.
Osteoporosis
(OP)
is
a
systemic
and
retrogressive
disease
characterized
by
decreased
bone
density
fragile
microstructure.
Extracellular
vesicles
(EVs),
cell‐free
system
with
phospholipid
bilayer
released
cells
that
cannot
be
replicated,
have
unique
nanostructure,
stable
drug‐loading
capacity,
good
biocompatibility,
playing
an
important
role
in
regulating
the
gut‐skeletal
axis.
A
growing
body
of
research
demonstrates
gut
microbiota
(GM)
influence
development
OS,
while
bacteria‐derived
EVs
(BEVs)
become
new
dialogue
medium
between
bone.
Additionally,
organoids
are
3D
cell
clusters
vitro
highly
simulate
structure
function
corresponding
organs.
Intestinal
organoids‐derived
(IOEVs)
serve
as
another
promising
communication
due
to
their
significant
physiological
effects.
Herein,
three
types
gut‐bone
axes,
including
traditional,
BEVs‐based,
IOEVs‐based
axes
innovatively
proposed.
The
impact
BEVs‐based
on
OP
focused.
comprehensive
summary
will
reveal
relationship
intestinal
provide
solution
therapy.
