Biomedicines,
Год журнала:
2024,
Номер
12(12), С. 2665 - 2665
Опубликована: Ноя. 22, 2024
Liver
fibrosis
represents
a
common
pathway
in
the
progression
of
various
chronic
liver
diseases
towards
cirrhosis
and
failure.
Extracellular
vesicles
(EVs)
are
membrane-enclosed
particles
secreted
by
diverse
cell
types,
including
exosomes,
microvesicles,
apoptotic
vesicles,
recently
identified
migrasomes.
These
can
be
taken
up
recipient
cells,
thereby
modulating
their
function
through
transport
cargo
molecules.
EVs
facilitate
intercellular
communication
play
significant
role
development
fibrosis.
Moreover,
detection
body
fluids
offers
sensitive
diagnostic
tools
for
assessing
Additionally,
may
serve
as
therapeutic
targets,
potential
agents,
drug
delivery
vehicles.
This
article
reviews
recent
advances
field
concerning
related
diseases,
with
particular
focus
on
newly
discovered
migrasomes
intracellular
crosstalk
within
liver.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Июль 8, 2024
Objective
Although
urinary
extracellular
vesicles
(uEVs)
have
been
extensively
studied
in
various
cancers,
their
involvement
breast
cancer
(BC)
remains
largely
unexplored.
The
non-invasive
nature
of
urine
as
a
biofluid
and
its
abundant
protein
content
offer
considerable
potential
for
the
early
detection
cancer.
Methods
This
study
analyzed
proteomic
profiles
uEVs
from
BC
patients
healthy
controls
(HC).
dysregulation
ECM1
ANXA1
was
validated
larger
cohort
128
patients,
25
HC
benign
nodules
(BBN)
by
chemiluminescence
assay
(CLIA).
expression
levels
were
also
confirmed
MMTV-PyMT
transgenic
mouse
models.
Results
LC-MS/MS
analysis
identified
571
dysregulated
proteins
patients.
selected
validation
BBN
using
CLIA,
fold
change
showed
significant
difference
more
than
10
with
p
-value<0.05.
Protein
significantly
increased
In
addition,
mice
observed
to
increase
progressively
progression
Conclusion
We
developed
simple
purification-free
platform
isolate
quantitatively
detect
WGA-coupled
magnetic
beads
CLIA.
Our
results
suggest
that
could
potentially
serve
diagnostic
biomarkers
Biomedicines,
Год журнала:
2024,
Номер
12(12), С. 2665 - 2665
Опубликована: Ноя. 22, 2024
Liver
fibrosis
represents
a
common
pathway
in
the
progression
of
various
chronic
liver
diseases
towards
cirrhosis
and
failure.
Extracellular
vesicles
(EVs)
are
membrane-enclosed
particles
secreted
by
diverse
cell
types,
including
exosomes,
microvesicles,
apoptotic
vesicles,
recently
identified
migrasomes.
These
can
be
taken
up
recipient
cells,
thereby
modulating
their
function
through
transport
cargo
molecules.
EVs
facilitate
intercellular
communication
play
significant
role
development
fibrosis.
Moreover,
detection
body
fluids
offers
sensitive
diagnostic
tools
for
assessing
Additionally,
may
serve
as
therapeutic
targets,
potential
agents,
drug
delivery
vehicles.
This
article
reviews
recent
advances
field
concerning
related
diseases,
with
particular
focus
on
newly
discovered
migrasomes
intracellular
crosstalk
within
liver.
