The interplay between sleep and gut microbiota

Brain Research Bulletin, Год журнала: 2022, Номер 180, С. 131 - 146

Опубликована: Янв. 13, 2022

Язык: Английский

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Current Treatment Options and Therapeutic Insights for Gastrointestinal Dysmotility and Functional Gastrointestinal Disorders

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Янв. 25, 2022

Functional gastrointestinal disorders (FGIDs) have been re-named as of gut-brain interactions. These conditions are not only common in clinical practice, but also the community. In reference to Rome IV criteria, most FGIDs, include functional dyspepsia (FD) and irritable bowel syndrome (IBS). Additionally, there is substantial overlap these other specific motility disorders, such gastroparesis. heterogeneous intertwined with several proposed pathophysiological mechanisms, altered gut motility, intestinal barrier dysfunction, immune visceral hypersensitivity, GI secretion, presence degree bile acid malabsorption, microbial dysbiosis, alterations axis. The treatment options currently available lifestyle modifications, dietary microbiota manipulation interventions including fecal transplantation, prokinetics, antispasmodics, laxatives, centrally peripherally acting neuromodulators. However, that targets mechanisms underlying symptoms scanty. Pharmacological agents developed based on cellular molecular pathologies might provide best avenue for future pharmaceutical development. therapies lack long-term effectiveness safety their use treat FGIDs. Furthermore, fundamental challenges treating should be defined; instance, 1. Cause effect cannot disentangled between due current entail off-label medications symptoms. 2. Despite knowledge our plays an essential part maintaining health, exact functions homeostasis still unclear. What constitutes a healthy microbiome further, precise definition dysbiosis lacking. More comprehensive, large-scale, longitudinal studies utilizing multi-omics data needed dissect contribution disease pathogenesis. Accordingly, we review options, insight pathophysiology, therapeutic modalities, challenges, clues care management dyspepsia, gastroparesis, syndrome, constipation, diarrhea.

Язык: Английский

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Revisiting the Intestinal Microbiome and Its Role in Diarrhea and Constipation

Microorganisms, Год журнала: 2023, Номер 11(9), С. 2177 - 2177

Опубликована: Авг. 29, 2023

The gut microbiota represents a community of microorganisms (bacteria, fungi, archaea, viruses, and protozoa) that colonize the are responsible for mucosal structural integrity immune metabolic homeostasis. relationship between microbiome human health has been intensively researched in past years. It is now widely recognized microbial composition highly general host. Among diseases have linked to an altered population diarrheal illnesses functional constipation. capacity probiotics modulate population, strengthen intestinal barrier, system together with their antioxidant properties encouraged research probiotic therapy many gastrointestinal afflictions. Dietary lifestyle changes use seem play important role easing constipation effectively alleviating diarrhea by suppressing germs involved. This review aims describe how bacteria specific strains could interfere bring benefits as associated treatment

Язык: Английский

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Gastroparesis: The Complex Interplay with Microbiota and the Role of Exogenous Infections in the Pathogenesis of the Disease

Microorganisms, Год журнала: 2023, Номер 11(5), С. 1122 - 1122

Опубликована: Апрель 25, 2023

Gastroparesis (GP) is a disorder of gastric functions that defined by objective delayed emptying in the absence mechanical obstruction. This disease characterized symptoms such as nausea, post-prandial fullness, and early satiety. GP significantly impacts patients’ quality life contributes to substantial healthcare expenses for families society. However, epidemiological burden difficult evaluate, mainly due its significant overlap with functional dyspepsia (FD). FD represent two similar diseases. The pathophysiology both disorders involves abnormal motility, visceral hypersensitivity, mucosal inflammation. Moreover, conditions share symptoms, epigastric pain, bloating, latest evidence reveals dysbiosis directly or indirectly connected gut–brain axis alterations, which are basis pathogenesis GP. Furthermore, role microbiota development gastroparesis was demonstrated some clinical studies, found use probiotics correlated improvements time (GET). Infections (with viruses, bacteria, protozoa) proven etiology but have not been sufficiently considered current practice. Previous viral infections can be about 20% idiopathic cases. during systemic protozoal represents huge concern compromised patients, few data exist on topic. comprehensive narrative review analyzes relationship between microorganisms We explore, one hand, correlation gut pathogenesis, including treatment implications, and, other association exogenous disease.

Язык: Английский

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Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8250 - 8250

Опубликована: Июль 28, 2024

The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications

Язык: Английский

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Elucidating the Impact of Key Filtration Parameters on the Recovery of Peptides and Oligosaccharides From Colostrum Whey Permeate at Pilot‐Scale

Sustainable Food Proteins, Год журнала: 2025, Номер 3(1)

Опубликована: Янв. 24, 2025

ABSTRACT Bovine colostrum whey permeate, a byproduct of commercial ultrafiltration for protein isolation, contains bioactive peptides and prebiotic oligosaccharides. The study aimed to assess how feed flow transmembrane pressure affect the concentration oligosaccharides from permeate by comparing efficiency Synder NFW (300–500 Da) Hydracore 70 (500–700 nanofiltration membranes. Additionally, it evaluated in vitro biological activity resulting retentates, which were enriched peptides. Despite nearly 8‐fold faster fluxes, membrane achieved equivalently high retention (99%–100%) compared membrane. These results imply that greater fouling occurred larger pores 70, as evidenced resistance measurements. Optimum filtration conditions each (Synder NFW: 18.05 L min −1 , 27 bar; 70: 3.95 35 bar 70) used concentrate factor 15. Both retentates showed equivalent selective toward Bifidobacterium longum subsp. infantis ATCC15697 growth (1% w/v powder), ACE‐inhibition at 1.67 mg mL powder 54%, 70%: 67%), α‐glucosidase inhibitory 100 48%, 53%). exhibited 26 29 μmol Trolox equivalents/g membranes, respectively . Glycomic profiling identified potentially antidiabetic oligosaccharides, while peptidomic coincided with observed bioactivity. show key bovine recovering potential health benefits.

Язык: Английский

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Lifestyle patterns influence the composition of the gut microbiome in a healthy Chinese population

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Сен. 2, 2023

High-throughput sequencing allows for the comprehensive analysis of human intestinal microbiota. However, extensive association analyses between microbiome and lifestyle differences in Chinese population are limited. Here, we carried out an independent cohort study-the Healthy Gut Project (n = 483)-where correlations gut microbiota dietary variables a healthy defined. We collected both questionnaire data, including basic information variables, fecal stools from enrolled volunteers. then performed 16S rRNA on microbial DNA isolated to assess composition found that Prevotella Bacteroides were most abundant genera microbiome. Additionally, 9 29 clinical questionnaire-based phenotype covariates be associated with variation Among these phenotypes, sleep procrastination, negative mood, drinking habits had largest effect size. appreciable urbanization was observed, resulting decreased intra-individual diversity, increased inter-individual abundance enterotype. The results this study provide foundation assessing community structure at baseline population. Furthermore, also provides insights into understanding how distinctive living influence relationships systemic health state.

Язык: Английский

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The Association between Dysbiosis and Neurological Conditions Often Manifesting with Chronic Pain

Biomedicines, Год журнала: 2023, Номер 11(3), С. 748 - 748

Опубликована: Март 1, 2023

The prevalence of neurological conditions which manifest with chronic pain is increasing globally, where the World Health Organisation has now classified as a risk factor for death by suicide. While many have definitive underlying aetiology, non-somatic represent difficult-to-diagnose and difficult-to-treat public health issues. interaction immune system nervous become an important area in understanding occurrence neuroinflammation, nociception, peripheral central sensitisation seen pain. More recently, however, role resident microbial species human gastrointestinal tract evident. Dysbiosis, alteration present favour non-beneficial pathogenic emerged conditions, including functional somatic syndromes, autoimmune disease diseases. In particular, decreased abundance small chain fatty acid, e.g., butyrate-producing bacteria, Faecalibacterium, Firmicutes some Bacteroides spp., frequently evident morbidities associated long-term Microbes involved production neurotransmitters serotonin, GABA, glutamate dopamine, mediate gut-brain, axis are also important. This review outlines dysbiosis states manifesting pain, overlap patients.

Язык: Английский

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Microbiota in Autism Spectrum Disorder: A Systematic Review

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(23), С. 16660 - 16660

Опубликована: Ноя. 23, 2023

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by several core symptoms: restricted interests, communication difficulties, and impaired social interactions. Many ASD children experience gastrointestinal functional disorders, impacting their well-being. Emerging evidence suggests that gut microbiota imbalance may exacerbate symptoms. Our review assesses the in with interventions targeting modulation. The analysis of forty-four studies (meta-analyses, reviews, original research) reveals insights into microbiota-ASD relationship. While specific alterations are mixed, some trends emerge. exhibit increased Firmicutes (36-81%) Pseudomonadota (78%) decreased Bacteroidetes (56%). to ratio tends be lower (56%) compared without ASD, which correlates behavioral abnormalities. Probiotics, particularly Lactobacillus, Bifidobacterium, Streptococcus strains, show promise alleviating symptoms (66%). Microbiota transfer therapy (MTT) seems have lasting benefits for one longitudinal study. Prebiotics can potentially help issues, needing further research conclusive efficacy due different being used. This highlights interplay, offering potential therapeutic avenues gut-brain axis. However, study heterogeneity, small sample sizes, methodological variations emphasize need comprehensive, standardized research. Future investigations unveil mechanisms linking ultimately enhancing quality life affected individuals.

Язык: Английский

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Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time?

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Июнь 1, 2023

Chronic low-grade inflammation affects health and is associated with aging age-related diseases. Dysregulation of the gut flora an important trigger for chronic inflammation. Changes in composition exposure to related metabolites have effect on inflammatory system host. This results development crosstalk between barrier immune system, contributing impairment health. Probiotics can increase diversity microbiota, protect barrier, regulate immunity, thereby reducing Therefore, use probiotics a promising strategy beneficial immunomodulation protection through microbiota. These processes might positively influence diseases, which are common elderly.

Язык: Английский

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