Optical, contact-free assessment of brain tissue stiffness and neurodegeneration DOI Creative Commons
Philip Binner, Ilya Starshynov, Gonzalo S. Tejeda

и другие.

Biomedical Optics Express, Год журнала: 2024, Номер 16(2), С. 447 - 447

Опубликована: Дек. 19, 2024

Dementia affects a large proportion of the world's population. Approaches that allow for early disease detection and non-invasive monitoring progression are desperately needed. Current approaches centred on costly imaging technologies such as positron emission tomography magnetic resonance imaging. We propose an alternative approach to assess neurodegeneration based diffuse correlation spectroscopy (DCS), remote optical sensing technique. employ this in mouse brains from healthy animals those with prion disease. find statistically significant difference speckle decorrelation times between prion-diseased animals. directly calibrated our DCS technique using hydrogel samples varying Young's modulus, indicating we can optically measure changes brain tissue stiffness order 60 Pa (corresponding 1 s change time). holds promise contact-free assessment alteration due neurodegeneration, similar sensitivity contact-based (e.g. nanoindentation) approaches.

Язык: Английский

Linked patterns of symptoms and cognitive covariation with functional brain controllability in major depressive disorder DOI Creative Commons
Qian Li, Youjin Zhao,

Yongbo Hu

и другие.

EBioMedicine, Год журнала: 2024, Номер 106, С. 105255 - 105255

Опубликована: Июль 19, 2024

Controllability analysis is an approach developed for evaluating the ability of a brain region to modulate function in other regions, which has been found be altered major depressive disorder (MDD). Both symptoms and cognitive impairments are prominent features MDD, but case-control differences controllability between MDD controls can not fully interpret contribution both clinical cognition linked patterns among them MDD.

Язык: Английский

Процитировано

22
Predicting treatment outcomes in major depressive disorder using brain magnetic resonance imaging: a meta-analysis DOI
Fenghua Long, Yufei Chen, Qian Zhang

и другие.

Molecular Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Авг. 26, 2024

Язык: Английский

Процитировано

17
Brain structural and functional magnetic resonance imaging alterations in individuals with convergence insufficiency DOI Open Access
Yuxia Wang, Gantian Huang, Ye Wu

и другие.

Ophthalmic and Physiological Optics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Abstract Purpose Individuals with convergence insufficiency (CI) encounter challenges in turning their eyes inward during near work. It is unclear how this relates to brain structural and functional alterations. This study aimed explore the neural mechanism underlying CI using multimodal magnetic resonance imaging (MRI). Methods Thirty‐four participants 35 healthy controls (HC) were recruited, who underwent visual examinations MRI scanning. Structural data analysed calculate cortical thickness, volume surface area. Fractional amplitude of low‐frequency fluctuation (fALFF) seed‐based connectivity obtained from resting‐state data. The metrics compared between two groups followed by correlation analyses clinical measurements significant features. Results Relative HC, individuals had lower grey matter (GMV) area right frontal eye fields, parietal fields left medial orbitofrontal cortex, higher GMV middle inferior temporal gyri fALFF cerebellum connection bilateral cerebellums. gyrus positively correlated point all participants. Conclusions Lower oculomotor cortices activity may underpin dysfunction fatigue, while reflect partial compensation for cortex defects, thereby maintaining attention parallax information processing. enhance understanding revealing impact abnormal experiences on disassociated alterations vergence system.

Язык: Английский

Процитировано

3
Shared and differing functional connectivity abnormalities of the default mode network in mild cognitive impairment and Alzheimer’s disease DOI
Yaxuan Wang, Qian Li, Yao Li

и другие.

Cerebral Cortex, Год журнала: 2024, Номер 34(3)

Опубликована: Март 1, 2024

Abstract Alzheimer’s disease (AD) and mild cognitive impairment (MCI) both show abnormal resting-state functional connectivity (rsFC) of default mode network (DMN), but it is unclear to what extent these abnormalities are shared. Therefore, we performed a comprehensive meta-analysis, including 31 MCI studies 20 AD studies. patients, compared controls, showed decreased within-DMN rsFC in bilateral medial prefrontal cortex/anterior cingulate cortex (mPFC/ACC), precuneus/posterior (PCC), right temporal lobes, left angular gyrus increased between DMN inferior gyrus. within mPFC/ACC precuneus/PCC occipital dorsolateral cortex. Conjunction analysis shared precuneus/PCC. Compared MCI, had lobes. share likely underpinning episodic memory deficits neuropsychiatric symptoms, differ alterations related impairments other domains such as language, vision, execution. This may throw light on neuropathological mechanisms two stages dementia.

Язык: Английский

Процитировано

14
Common and distinct cortical thickness alterations in youth with autism spectrum disorder and attention-deficit/hyperactivity disorder DOI Creative Commons
Wanfang You, Qian Li, Lizhou Chen

и другие.

BMC Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Март 4, 2024

Abstract Background Autism spectrum disorder (ASD) and attention-deficit/hyperactivity (ADHD) are neurodevelopmental disorders with overlapping behavioral features genetic etiology. While brain cortical thickness (CTh) alterations have been reported in ASD ADHD separately, the degree to which associated common distinct patterns of CTh changes is unclear. Methods We searched PubMed, Web Science, Embase, Science Direct from inception 8 December 2023 included studies comparing youth (age less than 18) or typically developing controls (TDC). conducted a comparative meta-analysis vertex-based identify ADHD. Results Twelve datasets involving 458 individuals 10 383 were analysis. Compared TDC, showed increased bilateral superior frontal gyrus, left middle temporal right parietal lobule (SPL) decreased temporoparietal junction (TPJ). precentral gyri, postcentral TPJ relative TDC. Conjunction analysis both shared reduced located default mode network (DMN). Comparative analyses indicated had greater SPL dorsal attention thinner ventral Conclusions These results suggest DMN an neurobiological feature This alteration together might be related altered biological motion processing ASD, while abnormalities sensorimotor systems may contribute control problems The disorder-specific disparate networks provides novel insight into symptoms attentional deficits two disorders. Trial registration PROSPERO CRD42022370620. Registered on November 9, 2022.

Язык: Английский

Процитировано

13
Viscoelasticity in 3D Cell Culture and Regenerative Medicine: Measurement Techniques and Biological Relevance DOI Creative Commons
Payam Eliahoo,

Hesam Setayesh,

Tyler Hoffman

и другие.

ACS Materials Au, Год журнала: 2024, Номер 4(4), С. 354 - 384

Опубликована: Июнь 18, 2024

The field of mechanobiology is gaining prominence due to recent findings that show cells sense and respond the mechanical properties their environment through a process called mechanotransduction. cells, cell organelles, extracellular matrix are understood be viscoelastic. Various technologies have been researched developed for measuring viscoelasticity biological materials, which may provide insight into both cellular mechanisms functions Here, we explain concept introduce major techniques used measure various soft materials in different length- timescale frames. topology material undergoing testing, geometry probe, magnitude exerted stress, resulting deformation should carefully considered choose proper technique each application. Lastly, discuss several applications 3D culture tissue models regenerative medicine, including organoids, organ-on-a-chip systems, engineered constructs, tunable viscoelastic hydrogels bioprinting cell-based therapies.

Язык: Английский

Процитировано

8
The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain DOI Creative Commons
Judith Bergs, Anna S. Morr, Rafaela V. Silva

и другие.

Advanced Science, Год журнала: 2024, Номер 11(31)

Опубликована: Июнь 14, 2024

Abstract Mechanically, the brain is characterized by both solid and fluid properties. The resulting unique material behavior fosters proliferation, differentiation, repair of cellular vascular networks, optimally protects them from damaging shear forces. Magnetic resonance elastography (MRE) a noninvasive imaging technique that maps mechanical properties in vivo. MRE studies have shown abnormal processes such as neuronal degeneration, demyelination, inflammation, leakage lead to tissue softening. In contrast, network formation, higher pressure result stiffening. addition, viscosity has been reported change with normal blood perfusion variability maturation well disease conditions tumor invasion. this article, contributions neuronal, glial, extracellular, networks are discussed coarse‐grained parameters determined MRE. This reductionist multi‐network model mechanics helps explain many observations terms microanatomical changes suggests cerebral viscoelasticity suitable marker for disease.

Язык: Английский

Процитировано

6
Biomechanical perspectives on traumatic brain injury in the elderly: A comprehensive review DOI
Hamed Abdi, David Sánchez‐Molina, Silvia García‐Vilana

и другие.

Progress in Biomedical Engineering, Год журнала: 2025, Номер 7(2), С. 022001 - 022001

Опубликована: Янв. 6, 2025

Traumatic brain injuries (TBIs) pose a significant health concern among the elderly population, influenced by age-related physiological changes and prevalence of neurodegenerative diseases. Understanding biomechanical dimensions TBIs in this demographic is vital for developing effective preventive strategies optimizing clinical management. This comprehensive review explores intricate biomechanics elderly, integrating medical aging studies, experimental head tissues, numerical simulations. Research reveals that global atrophy normal occurs at annual rates -0.2% to -0.5%. In contrast, diseases such as Alzheimer's, Parkinson's, multiple sclerosis are associated with significantly higher atrophy. These variations underscore importance considering differing patterns when evaluating elderly. Experimental studies further demonstrate mechanical properties critical tissues increase vulnerability injuries. Numerical simulations provide insights into response traumatic events, aiding injury prediction strategy development tailored Biomechanical analysis essential understanding mechanisms forms basis strategies. By incorporating local age-specific impact characteristics models, researchers can create targeted interventions reduce risk vulnerable populations. Future research should focus on refining these models data better predict outcomes enhance care. Advancements field promise improve risks population.

Язык: Английский

Процитировано

0
Measurement of biomechanical properties of transversely isotropic biological tissue using traveling wave expansion DOI
Shengyuan Ma, He Zhao, Runke Wang

и другие.

Medical Image Analysis, Год журнала: 2025, Номер 101, С. 103457 - 103457

Опубликована: Янв. 9, 2025

Язык: Английский

Процитировано

0
Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders DOI Creative Commons
Emmanuel Ortega-Robles, Benito de Celis Alonso, Jessica Cantillo-Negrete

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(1), С. 79 - 79

Опубликована: Янв. 16, 2025

Advanced magnetic resonance imaging (MRI) techniques are transforming the study of movement disorders by providing valuable insights into disease mechanisms. This narrative review presents a comprehensive overview their applications in this field, offering an updated perspective on potential for early diagnosis, monitoring, and therapeutic evaluation. Emerging MRI modalities such as neuromelanin-sensitive imaging, diffusion-weighted magnetization transfer relaxometry provide sensitive biomarkers that can detect microstructural degeneration, iron deposition, connectivity disruptions key regions like substantia nigra. These enable earlier more accurate differentiation disorders, including Parkinson's disease, progressive supranuclear palsy, multiple system atrophy, corticobasal Lewy body frontotemporal dementia, Huntington's dystonia. Furthermore, provides objective metrics tracking progression assessing efficacy, making it indispensable tool clinical trials. Despite these advances, absence standardized protocols limits integration routine practice. Addressing gap incorporating systematically could bring field closer to leveraging advanced personalized treatment strategies, ultimately improving outcomes individuals with disorders.

Язык: Английский

Процитировано

0