Discover Mental Health,
Год журнала:
2023,
Номер
3(1)
Опубликована: Янв. 3, 2023
(1)
To
summarize
the
mental
conditions
that
may
accompany
persistent
symptoms
following
acute
infection
by
SARS-CoV-2,
often
termed
Long
Covid;
(2)
to
formulate
treatment
based
upon
brain
cells
are
dominantly
affected.(1)
Review
reports
relating
occurring
in
Covid.
drugs
address
affected
Covid,
and
suggest
pharmacotherapy
for
those
patients
whose
response
psychotherapy
is
suboptimal.Long
Covid
affects
~
10%
of
infected
affect
20%
persons
with
The
cell-types
have
been
demonstrated
as
astrocytes,
oligodendrocytes,
neurons,
endothelial
cells/pericytes,
microglia.
Lithium
fluoxetine
each
all
four
cell-types.
Low
dosage
likely
be
well-tolerated
cause
neither
clinically
important
adverse
events
(AE)
nor
serious
(SAE).For
suboptimal,
lithium
should
administered
combination
both
depth
benefit
reduction
dosages.
General Psychiatry,
Год журнала:
2023,
Номер
36(2), С. e100996 - e100996
Опубликована: Март 1, 2023
Type
2
diabetes
(T2D)
is
a
chronic
metabolic
disorder
with
high
comorbidity
mental
disorders.
The
genetic
links
between
attention-deficit/hyperactivity
(ADHD)
and
T2D
have
yet
to
be
elucidated.We
aim
assess
shared
genetics
potential
associations
ADHD
T2D.We
performed
correlation,
two-sample
Mendelian
randomisation
polygenic
overlap
analyses
T2D.
genome-wide
association
study
(GWAS)
summary
results
of
(80
154
cases
853
816
controls),
ADHD2019
(20
183
35
191
controls
from
the
2019
GWAS
dataset)
ADHD2022
(38
691
275
986
2022
were
used
for
analyses.
dataset
was
obtained
DIAGRAM
Consortium.
datasets
Psychiatric
Genomics
We
compared
signals
reveal
variation
using
larger
dataset.
Moreover,
molecular
pathways
constructed
based
on
large-scale
literature
data
understand
connection
T2D.T2D
has
positive
correlations
(rg=0.33)
(rg=0.31).
Genetic
liability
associated
an
increased
risk
(odds
ratio
(OR):
1.30,
p<0.001),
while
had
suggestive
causal
effect
(OR:
p=0.086).
higher
1.05,
p=0.001)
1.03,
p<0.001).
analysis
showed
that
most
variants
are
ADHD2022.
three
overlapping
loci.
Molecular
pathway
suggests
could
promote
each
other
through
inflammatory
pathways.Our
demonstrates
substantial
bidirectional
General Psychiatry,
Год журнала:
2023,
Номер
36(2), С. e101006 - e101006
Опубликована: Апрель 1, 2023
We
aimed
to
evaluate
whether
major
depressive
disorder
(MDD)
could
aggravate
the
outcomes
of
coronavirus
disease
2019
(COVID-19)
or
genetic
liability
COVID-19
trigger
MDD.We
assess
bidirectional
causal
associations
between
MDD
and
COVID-19.We
performed
correlation
Mendelian
randomisation
(MR)
analyses
potential
three
outcomes.
Literature-based
network
analysis
was
conducted
construct
molecular
pathways
connecting
found
that
has
positive
correlations
with
(rg:
0.10-0.15).
Our
MR
indicated
is
associated
increased
risks
infection
(odds
ratio
(OR)=1.05,
95%
confidence
interval
(CI):
1.00
1.10,
p=0.039).
However,
did
not
confer
any
effects
on
MDD.
Pathway
identified
a
panel
immunity-related
genes
may
mediate
links
COVID-19.Our
study
suggests
increase
susceptibility
COVID-19.
findings
emphasise
need
social
support
improve
mental
health
intervention
networks
for
people
mood
disorders
during
pandemic.
Translational Psychiatry,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 23, 2024
Abstract
Previous
studies
have
observed
a
significant
comorbidity
between
Alzheimer’s
disease
(AD)
and
some
other
neuropsychiatric
disorders.
However,
the
mechanistic
connections
disorders
AD
are
not
well
understood.
We
conducted
Mendelian
randomization
analysis
to
appraise
potential
influences
of
18
neurodegenerative
on
AD.
found
that
four
causally
associated
with
increased
risk
for
AD,
including
bipolar
disorder
(BD)
(OR:
1.09),
migraine
schizophrenia
1.05),
Parkinson’s
(PD)
1.07),
while
attention-deficit/hyperactivity
(ADHD)
was
decreased
0.80).
In
case
amyotrophic
lateral
sclerosis
1.04)
Tourette’s
syndrome
there
suggestive
evidence
their
causal
effects
Our
study
shows
genetic
components
predisposing
BD,
migraine,
schizophrenia,
PD
may
promote
development
ADHD
be
reduced
The
treatments
aimed
at
alleviating
diseases
earlier
onset
also
influence
AD-related
cognitive
decline,
which
is
typically
later
in
life.
Journal of Medical Virology,
Год журнала:
2022,
Номер
95(1)
Опубликована: Ноя. 1, 2022
With
the
continued
spread
of
COVID-19
globally,
it
is
crucial
to
identify
potential
risk
or
protective
factors
associated
with
COVID-19.
Here,
we
performed
genetic
correlation
analysis
and
Mendelian
randomization
examine
relationships
between
hospitalization
405
health
conditions
lifestyle
in
456
422
participants
from
UK
Biobank.
The
revealed
134
positive
65
negative
correlations,
including
those
intakes
a
variety
dietary
components.
MR
indicates
that
set
body
fat-related
traits,
maternal
smoking
around
birth,
basal
metabolic
rate,
lymphocyte
count,
peripheral
enthesopathies
allied
syndromes,
blood
clots
leg,
arthropathy
are
causal
for
severe
COVID-19,
while
higher
education
attainment,
physical
activity,
asthma,
never
status
protect
against
illness.
Our
findings
have
implications
stratification
patients
prevention
its
outcomes.
Frontiers in Genetics,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 3, 2023
Background:
Tobacco
smoking
and
alcohol
consumption
have
been
associated
with
frailty
in
observational
studies.
We
sought
to
examine
whether
these
associations
reflect
causality
using
the
two-sample
Mendelian
randomization
(MR)
design.
Methods:
used
summary
genome-wide
association
statistics
for
initiation
(N
=
2,669,029),
2,428,851),
index
(FI,
N
175,226)
participants
of
European
ancestry.
Both
univariable
multivariable
MR
were
performed
comprehensively
evaluate
independent
effects
on
FI,
accompanied
by
multiple
sensitivity
analyses.
Results
verified
lifetime
use
disorder.
Reverse
direction
was
undertaken
assess
potential
reverse
causation.
Results:
Genetic
predisposition
significantly
increased
FI
(univariable
MR:
β
0.345;
95%
confidence
interval
[CI]
0.316
0.374;
p
1.36E-113;
0.219;
CI
0.197
0.241;
2.44E-83).
Genetically
predicted
showed
a
suggestive
-0.090;
-0.151
-0.029;
0.003;
-0.153;
-0.212
-0.094;
2.03E-07),
inconsistent
results
In
complementary
analysis,
genetic
smoking,
but
not
disorder
FI.
There
is
no
convincing
evidence
Conclusion:
The
present
study
supported
as
causal
risk
factor
frailty.
Further
research
warranted
investigate
has
role
Journal of Medical Virology,
Год журнала:
2023,
Номер
95(4)
Опубликована: Март 23, 2023
To
evaluate
the
genetic
relationship
between
hypertension
and
COVID-19
explore
molecular
pathways
linking
to
COVID-19.
We
performed
correlation
Mendelian
randomization
(MR)
analyses
assess
potential
associations
hospitalized
compared
genome-wide
association
signals
reveal
shared
variation
Moreover,
hypertension-driven
were
constructed
based
on
large-scale
literature
data
understand
influence
of
at
level.
Hypertension
has
a
positive
with
(rg
=
0.19).
The
MR
indicate
that
liability
confers
causal
effect
(odds
ratio
[OR]:
1.05,
confidence
interval
[CI]:
1.00-1.09,
p
0.030).
have
three
overlapping
loci
share
eight
protein-coding
risk
genes,
including
ABO,
CSF2,
FUT2,
IZUMO1,
MAMSTR,
NPNT,
RASIP1,
WNT3.
Molecular
pathway
analysis
suggests
may
promote
development
through
induction
inflammatory
pathways.
Our
study
genetically
determined
increase
for
severe
connecting
underline
links
Journal of Medical Virology,
Год журнала:
2022,
Номер
95(1)
Опубликована: Дек. 26, 2022
Neuroinflammation
caused
by
COVID-19
negatively
impacts
brain
metabolism
and
function,
while
pre-existing
pathology
may
contribute
to
individuals'
vulnerability
the
adverse
consequences
of
COVID-19.
We
used
summary
statistics
from
genome-wide
association
studies
(GWAS)
perform
Mendelian
randomization
(MR)
analyses,
thus
assessing
potential
associations
between
multiple
sclerosis
(MS)
two
outcomes
(severe
acute
respiratory
syndrome
coronavirus
2
[SARS-CoV-2]
infection
hospitalization).
Genome-wide
risk
genes
were
compared
GWAS
datasets
on
hospitalized
MS.
Literature-based
analysis
was
conducted
construct
molecular
pathways
connecting
MS
found
that
genetic
liability
confers
a
causal
effect
(odd
ratio
[OR]:
1.09,
95%
confidence
interval:
1.03-1.16)
but
not
SARS-CoV-2
(1.03,
1.00-1.05).
Genetic
(1.15,
1.02-1.30).
Hospitalized
share
five
within
loci,
including
TNFAIP8,
HSD17B4,
CDC37,
PDE4A,
KEAP1.
Pathway
identified
panel
immunity-related
mediate
links
Our
study
suggests
associated
with
9%
increased
for
hospitalization,
15%
Immunity-related
underlie
link
QJM,
Год журнала:
2023,
Номер
116(9), С. 766 - 773
Опубликована: Июнь 7, 2023
COVID-19
might
cause
neuroinflammation
in
the
brain,
which
could
decrease
neurocognitive
function.
We
aimed
to
evaluate
causal
associations
and
genetic
overlap
between
intelligence.We
performed
Mendelian
randomization
(MR)
analyses
assess
potential
three
outcomes
intelligence
(N
=
269
867).
The
COVID
phenotypes
included
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection
501
486),
hospitalized
1
965
329)
critical
743
167).
Genome-wide
risk
genes
were
compared
genome-wide
association
study
(GWAS)
datasets
on
intelligence.
In
addition,
functional
pathways
constructed
explore
molecular
connections
intelligence.The
MR
indicated
that
liabilities
SARS-CoV-2
(odds
ratio
[OR]:
0.965,
95%
confidence
interval
[CI]:
0.939-0.993)
(OR:
0.989,
CI:
0.979-0.999)
confer
effects
There
was
suggestive
evidence
supporting
effect
of
0.988,
0.972-1.003).
Hospitalized
share
10
within
genomic
loci,
including
MAPT
WNT3.
Enrichment
analysis
showed
these
are
functionally
connected
distinct
subnetworks
30
linked
cognitive
decline.
pathway
revealed
COVID-19-driven
pathological
changes
brain
multiple
peripheral
systems
may
lead
impairment.Our
suggests
exert
a
detrimental
tau
protein
Wnt
signaling
mediate
influence
Journal of Integrative Neuroscience,
Год журнала:
2024,
Номер
23(4), С. 68 - 68
Опубликована: Апрель 1, 2024
Objective:
We
aimed
to
evaluate
bidirectional
genetic
relationships
between
posttraumatic
stress
disorder
(PTSD)
and
COVID-19.
Methods:
investigated
potential
causal
associations
PTSD
two
COVID-19
conditions
(COVID-19
hospitalization
SARS-CoV-2
infection)
via
Mendelian
randomization
(MR)
analyses.
Three
genome-wide
association
study
(GWAS)
summary
datasets
were
used
in
the
study,
including
(N
=
174,659),
infection
2,597,856),
2,095,324).
performed
a
literature-based
analysis
uncover
molecular
pathways
connecting
Results:
found
that
exerts
effect
on
(odds
ratio
(OR):
1.10,
95%
confidence
interval
(CI):
1.00–1.21,
p
0.048)
hospitalized
(OR:
1.34,
CI:
1.07–1.67,
0.001).
However,
both
not
associated
with
risk
of
PTSD.
Pathway
revealed
several
immunity-related
genes
may
link
Conclusions:
Our
suggests
was
increased
risks
for
susceptibility
severity.
Early
diagnosis
effective
treatment
individuals
infected
coronavirus
improve
management
outcomes
