From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

Advanced Science, Год журнала: 2024, Номер 11(17)

Опубликована: Фев. 21, 2024

Abstract Periodontitis is a dysbiosis‐driven inflammatory disease affecting the tooth‐supporting tissues, characterized by their progressive resorption, which can ultimately lead to tooth loss. A step‐wise therapeutic approach employed for periodontitis. After an initial behavioral and non‐surgical phase, intra‐bony or furcation defects may be amenable regenerative procedures. This review discusses technologies periodontal regeneration, highlighting current limitations future research areas. The search, performed on MEDLINE database, has identified available biomaterials, including biologicals (autologous platelet concentrates, hydrogels), bone grafts (pure putty), membranes. Biologicals have been critically analyzed in terms of composition, mechanism action, clinical applications. Although certain degree regeneration predictable class II defects, complete defect closure hardly achieved. Moreover, treating III remains challenging. key properties required functional are discussed, none commercially biomaterials possess all ideal characteristics. Therefore, needed promote advancement more effective targeted therapies Lastly, improving design reporting studies suggested strictly adhering Consolidated Standards Reporting Trials (CONSORT) 2010 statement.

Язык: Английский

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Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Апрель 16, 2024

Platelet-rich fibrin, a classical autologous-derived bioactive material, consists of fibrin scaffold and its internal loading growth factors, platelets, leukocytes, with the gradual degradation slow release physiological doses factors. PRF promotes vascular regeneration, proliferation migration osteoblast-related cells such as mesenchymal cells, osteoblasts, osteoclasts while having certain immunomodulatory anti-bacterial effects. has excellent osteogenic potential been widely used in field bone tissue engineering dentistry. However, there are still some limitations PRF, improvement biological properties is one most important issues to be solved. Therefore, it often combined scaffolds enhance mechanical delay degradation. In this paper, we present systematic review development platelet-rich derivatives, structure mechanisms, applications, optimization broaden their clinical applications provide guidance for translation.

Язык: Английский

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Supra-alveolar bone regeneration: Progress, challenges, and future perspectives

Composites Part B Engineering, Год журнала: 2024, Номер 283, С. 111673 - 111673

Опубликована: Июль 3, 2024

Язык: Английский

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Efficacy of biologics for the treatment of periodontal infrabony defects: An American Academy of Periodontology best evidence systematic review and network meta‐analysis

Journal of Periodontology, Год журнала: 2022, Номер 93(12), С. 1803 - 1826

Опубликована: Окт. 24, 2022

Abstract Background A large variety of biomaterials, biologics and membranes have been utilized in the past 40 years for regenerative treatment periodontal infrabony defects. Biologic agents progressively gained popularity among clinicians are routinely used regeneration. In alignment with goals American Academy Periodontology (AAP) Best Evidence Consensus (BEC) on use biologic mediators contemporary clinical practice, aim this sytematic review was to evaluate effect agents, specifically autogenous blood‐dervied products (ABPs), enamel matrix derivative (EMD) recombinant human platelet‐derived growth factor‐BB (rhPDGF‐BB), outcomes Methods detailed systematic search conducted identify eligible randomized control trials (RCTs) reporting therapy using frequentist mixed‐modeling approach network meta‐analysis (NMA), characterized by assessment three individual components an defect (the bone graft material [BG], agent, application a barrier membrane) performed compare relative efficacy different components, therapeutic modalities Results total 153 RCTs were included, 150 studies contributing NMA. The quantitative analysis showed that addition significantly improves radiographic outcomes, as compared BG flap procedures alone. Barrier enhanced but did not provide further benefits combination biologics. type (autogenous, allogeneic, xenogeneic or alloplastic) agent (EMD, platelet‐rich fibrin [PRF], plasma [PRP] rhPDGF‐BB) played significant role final Allogeneic BGs exhibited statistically superior gain than synthetic (p < 0.05 all comparisons), while rhPDGF‐BB PRF demonstrated higher stability gingival margin 0.01) fill/gain 0.05), together greater, although significant, attachment level pocket depth reduction, EMD PRP. Overall, largest size most parameters, including gain, less recession linear gain. Considering relatively high number presenting unclear risk bias, strength recommendation supporting PRP judged weak, EMD, deemed favor. Conclusions Biologics enhance therapy. Combination therapies involving + membrane be monotherapies. choice seems impact

Язык: Английский

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Regeneration of periodontal intrabony defects using platelet-rich fibrin (PRF): a systematic review and network meta-analysis

Odontology, Год журнала: 2024, Номер 112(4), С. 1047 - 1068

Опубликована: Май 21, 2024

Abstract One of the most promising approaches to correct periodontal bone defects and achieve regeneration is platelet-rich fibrin (PRF). This systematic review meta-analysis aimed evaluate using PRF compared other regenerative treatments. The data search retrieval process followed PRISMA guidelines. An electronic MEDLINE, Cochrane, PubMed databases was performed, selecting exclusively randomized clinical trials where following were measured: probing depth reduction (PD), attachment level gain (CAL), radiographic fill (RBF). Out 284 selected articles, 32 chosen based on inclusion criteria. use (PRF) + open flap debridement (OFD), metformin, plasma (PRP), OFD/bone graft (BG) significantly reduced PD improved CAL RBF. However, combination BG, STATINS CAL. intervention combined with different treatments such as OFD, PRP, has a significant impact improving

Язык: Английский

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Optimizing natural human-derived decellularized tissue materials for periodontal bone defect repair

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 748, С. 151297 - 151297

Опубликована: Янв. 8, 2025

Язык: Английский

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The effect of various Sn and Ca equal proportional addition on the microstructure, mechanical behavior and corrosion performance of Mg alloys

Materials Today Communications, Год журнала: 2024, Номер unknown, С. 110466 - 110466

Опубликована: Сен. 1, 2024

Язык: Английский

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Emerging roles of platelet concentrates and platelet-derived extracellular vesicles in regenerative periodontology and implant dentistry

APL Bioengineering, Год журнала: 2022, Номер 6(3)

Опубликована: Сен. 1, 2022

Platelet concentrates (PCs) are easily obtained from autogenous whole blood after centrifugation and have evolved through three generations of development to include platelet-rich plasma, fibrin, concentrated growth factor. Currently, PCs widely used for sinus floor elevation, alveolar ridge preservation, periodontal bone defects, guided regeneration, treatment gingival recession. More recently, been leveraged tissue regeneration promote oral soft hard in implant dentistry regenerative periodontology. ideal this purpose because they a high concentration platelets, factors, cytokines. Platelets shown release extracellular vesicles (P-EVs), which thought be essential PC-induced regeneration. This study reviewed the clinical application P-EVs surgery

Язык: Английский

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Modularized bioceramic scaffold/hydrogel membrane hierarchical architecture beneficial for periodontal tissue regeneration in dogs

Biomaterials Research, Год журнала: 2022, Номер 26(1)

Опубликована: Сен. 30, 2022

Destruction of alveolar bone and periodontal ligament due to disease often requires surgical treatment reconstruct the biological construction functions periodontium. Despite significant advances in dental implants past two decades, it remains a major challenge adapt grafts barrier membrane surgery complicated anatomy tooth defect contours. Herein, we developed novel biphasic hierarchical architecture with modularized shape based on achieve ideal outcomes. The integrated comprising nonstoichiometric wollastonite (nCSi) scaffolds gelatin methacrylate/silanized hydroxypropyl methylcellulose (GelMA/Si-HPMC) hydrogel was fabricated by digital light processing (DLP) photo-crosslinked injection technique respectively. rheological parameters, mechanical properties degradation rates composite hydrogels were investigated. L-929 cells cultured samples evaluate biocompatibility cell effect. Cell scratch assay, alkaline phosphatase (ALP) staining, alizarin red (AR) staining used reveal migration osteogenic ability mouse mandible-derived osteoblasts (MOBs). Subsequently, critical-size one-wall model dogs prepared tissue reconstruction potential architecture. personalized integrating tightly nCSi exhibited favorable viability vitro, while assay showed that osteoblast drastically correlated Si-HPMC content hydrogel. equivalent has proven good physiochemical properties, its potent occlusive effect vivo; meanwhile, architectures exerted strong regeneration capability intrabony models dogs. Histological examination effective biomimetic system; however, soft invasion observed control group. Our results suggested such have excellent as next-generation oral implants, this precisely tuned guided route offer an opportunity for improving damage reducing operation sensitivity.

Язык: Английский

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Autogenous platelet concentrates for treatment of intrabony defects—A systematic review with meta‐analysis

Periodontology 2000, Год журнала: 2024, Номер unknown

Опубликована: Окт. 19, 2024

Abstract To provide an overview of the use autogenous platelet concentrates (APCs) in periodontal regeneration and to conduct a systematic review (SR) treatment outcomes intrabony defects by using platelet‐rich fibrin (PRF) compared with other commonly utilized modalities. The eligibility criteria comprised randomized controlled trials (RCTs) comparing clinical PRF that Studies were classified into 21 categories five different groups as follows: Group I (1) open flap debridement (OFD) alone versus OFD/PRF, (2) OFD Titanium‐PRF (T‐PRF) II, (3) Comparative protocols (PRF vs. T‐PRF), III (Comparative PRF): (4) OFD/PRP (5) OFD/bone graft(BG)/PRGF OFD/BG/PRF, (6) OFD/EMD (7) OFD/BG/EMD (8) OFD/collagen membrane (CM) (9) OFD/BG/BM (10) OFD/BG IV (Addition groups) (11) (12) OFD/GTR + (13) OFD/EMD/PRF (14) OFD/BG/BM/PRF, V Biomaterial/Biomolecule OFD/PRF … (15) OFD/PRF/BG, (16) OFD/PRF/antibiotic, (17) OFD/PRF/Metformin, (18) OFD/PRF/Bisphosphonates, (19) OFD/PRF/Statins, (20) OFD/BG/PRF OFD/BG/PRF/Statins, (21) OFD/PRF/low‐level laser therapy (LLLT). Weighted means forest plots calculated for probing pocket depth (PPD), attachment level (CAL), radiographic bone fill (RBF). From 596 records identified, 55 RCTs included. I: statistically significantly reduced PPD improved CAL RBF when OFD. II: A significant difference between various was only observed PPD. III: No advantage found following groups: OFD/PRP, OFD/EMD, OFD/BM, or OFD/BG. IV: addition led improvements PPD, alone. V: either BG well three biomolecules (metformin, bisphosphonates, statins) CAL, and/or Similar results OFD/BG, OFD/BM. grafting material small may offer additional advantages, thus warranting further investigations. Future research investigating PRF, longer‐term outcomes, at human histological remains needed.

Язык: Английский

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